Gene description for XPO5
Gene name exportin 5
Gene symbol XPO5
Other names/aliases exp5
Species Homo sapiens
 Database cross references - XPO5
ExoCarta ExoCarta_57510
Entrez Gene 57510
HGNC 17675
MIM 607845
UniProt Q9HAV4  
 XPO5 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for XPO5
Molecular Function
    protein transporter activity GO:0008565 IEA
    Ran GTPase binding GO:0008536 IPI
    tRNA binding GO:0000049 IEA
    mRNA binding GO:0003729 IDA
    pre-miRNA binding GO:0070883 IDA
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
    RNA binding GO:0003723 TAS
Biological Process
    pre-miRNA export from nucleus GO:0035281 IMP
    positive regulation of RNA interference GO:1900370 IDA
    protein export from nucleus GO:0006611 IDA
    gene expression GO:0010467 TAS
Subcellular Localization
    nucleus GO:0005634 IDA
    RNA nuclear export complex GO:0042565 IDA
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified XPO5 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for XPO5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAGEA6  
Affinity Capture-MS Homo sapiens
2 NUP153  
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
3 NUP214  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
4 NEK6 10783
Affinity Capture-MS Homo sapiens
5 PHLDA3  
Affinity Capture-MS Homo sapiens
6 FADD 8772
Affinity Capture-MS Homo sapiens
7 PTP4A3  
Affinity Capture-MS Homo sapiens
8 SMAD4  
Affinity Capture-MS Homo sapiens
9 ILF3 3609
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
10 RAN 5901
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
11 SERINC3 10955
Affinity Capture-MS Homo sapiens
12 GSTK1 373156
Affinity Capture-MS Homo sapiens
13 EEF1A1 1915
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which XPO5 is involved
PathwayEvidenceSource
MicroRNA (miRNA) biogenesis TAS Reactome





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