Gene description for NME3
Gene name NME/NM23 nucleoside diphosphate kinase 3
Gene symbol NME3
Other names/aliases DR-nm23
NDPK-C
NDPKC
NM23-H3
NM23H3
c371H6.2
Species Homo sapiens
 Database cross references - NME3
ExoCarta ExoCarta_4832
Vesiclepedia VP_4832
Entrez Gene 4832
HGNC 7851
MIM 601817
UniProt Q13232  
 NME3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for NME3
Molecular Function
    nucleoside diphosphate kinase activity GO:0004550 IBA
    nucleoside diphosphate kinase activity GO:0004550 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    GTP biosynthetic process GO:0006183 IEA
    UTP biosynthetic process GO:0006228 IEA
    CTP biosynthetic process GO:0006241 IEA
    DNA repair GO:0006281 IMP
    apoptotic process GO:0006915 TAS
    mitochondrial fusion GO:0008053 IMP
    nucleoside triphosphate biosynthetic process GO:0009142 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 HTP
    mitochondrial outer membrane GO:0005741 IDA
    cytosol GO:0005829 TAS
    ciliary basal body GO:0036064 ISS
 Experiment description of studies that identified NME3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NME3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 TUBB2A 7280
Affinity Capture-MS Homo sapiens
3 DUSP22  
Affinity Capture-MS Homo sapiens
4 NME2 4831
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 SLC25A40  
Affinity Capture-MS Homo sapiens
6 C15orf48  
Affinity Capture-MS Homo sapiens
7 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
8 DUSP6 1848
Affinity Capture-MS Homo sapiens
9 TUBB 203068
Affinity Capture-MS Homo sapiens
10 VDAC3 7419
Affinity Capture-MS Homo sapiens
11 UBQLN4 56893
Two-hybrid Homo sapiens
12 HEATR6  
Affinity Capture-MS Homo sapiens
13 EHD1 10938
Affinity Capture-MS Homo sapiens
14 SLC25A29  
Affinity Capture-MS Homo sapiens
15 NUBP2 10101
Affinity Capture-MS Homo sapiens
16 NME1-NME2 654364
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 UBB 7314
Affinity Capture-MS Homo sapiens
18 NME4 4833
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 RPA2 6118
Proximity Label-MS Homo sapiens
20 UBQLN2 29978
Two-hybrid Homo sapiens
21 MTCH2 23788
Proximity Label-MS Homo sapiens
22 NME2P1 283458
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 BBS5 129880
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 UBQLN1 29979
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
25 BBS7 55212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 JAM2  
Two-hybrid Homo sapiens
27 AAR2 25980
Affinity Capture-MS Homo sapiens
28 BBS2 583
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 RPS6KB2  
Affinity Capture-MS Homo sapiens
30 TUBB1 81027
Affinity Capture-MS Homo sapiens
31 APP 351
Reconstituted Complex Homo sapiens
32 TUBA1A 7846
Affinity Capture-MS Homo sapiens
33 OCIAD1 54940
Proximity Label-MS Homo sapiens
34 NRBP1 29959
Affinity Capture-MS Homo sapiens
35 CLTCL1 8218
Affinity Capture-MS Homo sapiens
36 UBR4 23352
Affinity Capture-MS Homo sapiens
37 SGTB  
Two-hybrid Homo sapiens
38 CHCHD4  
Affinity Capture-MS Homo sapiens
39 XPO5 57510
Affinity Capture-MS Homo sapiens
40 PLD3 23646
Affinity Capture-MS Homo sapiens
41 SLC25A4 291
Affinity Capture-MS Homo sapiens
42 RPA3 6119
Proximity Label-MS Homo sapiens
43 NME1 4830
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 PRKAG1 5571
Affinity Capture-MS Homo sapiens
45 BBS9 27241
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 SFXN2  
Affinity Capture-MS Homo sapiens
47 TTC8 123016
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 MROH1 727957
Affinity Capture-MS Homo sapiens
49 ALDH3B1 221
Affinity Capture-MS Homo sapiens
50 PEX14 5195
Affinity Capture-MS Homo sapiens
51 DUSP9  
Affinity Capture-MS Homo sapiens
52 RNF2  
Affinity Capture-MS Homo sapiens
53 C9orf72  
Affinity Capture-MS Homo sapiens
54 BBS4 585
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 TKFC 26007
Affinity Capture-MS Homo sapiens
56 SSR1 6745
Affinity Capture-MS Homo sapiens
57 MAP3K15  
Affinity Capture-MS Homo sapiens
58 PLD6  
Affinity Capture-MS Homo sapiens
59 CPSF3L 54973
Affinity Capture-MS Homo sapiens
60 SGTA 6449
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
61 DUSP23 54935
Affinity Capture-MS Homo sapiens
62 AKAP1 8165
Proximity Label-MS Homo sapiens
63 BBS1 582
Affinity Capture-MS Homo sapiens
64 EXD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 TUBB8 347688
Affinity Capture-MS Homo sapiens
66 GPAT2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NME3 is involved
PathwayEvidenceSource
Interconversion of nucleotide di- and triphosphates TAS Reactome
Metabolism TAS Reactome
Metabolism of nucleotides TAS Reactome





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