Gene description for UBQLN4
Gene name ubiquilin 4
Gene symbol UBQLN4
Other names/aliases A1U
Species Homo sapiens
 Database cross references - UBQLN4
ExoCarta ExoCarta_56893
Entrez Gene 56893
HGNC 1237
MIM 605440
UniProt Q9NRR5  
 UBQLN4 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for UBQLN4
Molecular Function
    identical protein binding GO:0042802 IPI
    protein binding GO:0005515 IPI
    polyubiquitin binding GO:0031593 IDA
Biological Process
    regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 IMP
    negative regulation of autophagosome fusion GO:1902453 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 ISS
    cytosolic proteasome complex GO:0031597 IDA
    endoplasmic reticulum membrane GO:0005789 ISS
    nucleus GO:0005634 IDA
    nuclear proteasome complex GO:0031595 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
    autophagosome GO:0005776 IDA
 Experiment description of studies that identified UBQLN4 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UBQLN4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZNF297  
Two-hybrid Homo sapiens
2 ATXN1 6310
Two-hybrid Homo sapiens
3 PTN  
Two-hybrid Homo sapiens
4 NAE1 8883
Two-hybrid Homo sapiens
5 RXRA  
Two-hybrid Homo sapiens
6 SGNE1  
Two-hybrid Homo sapiens
7 SMARCB1 6598
Two-hybrid Homo sapiens
8 SMAD9  
Affinity Capture-MS Homo sapiens
9 EEF1A1 1915
Two-hybrid Homo sapiens
10 UNC119  
Two-hybrid Homo sapiens
11 RNF11 26994
Affinity Capture-MS Homo sapiens
12 SERPINH1 871
Two-hybrid Homo sapiens
13 PRPF40A 55660
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which UBQLN4 is involved
No pathways found

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