Gene description for CYB5R1
Gene name cytochrome b5 reductase 1
Gene symbol CYB5R1
Other names/aliases B5R.1
B5R1
B5R2
NQO3A2
humb5R2
Species Homo sapiens
 Database cross references - CYB5R1
ExoCarta ExoCarta_51706
Vesiclepedia VP_51706
Entrez Gene 51706
HGNC 13397
MIM 608341
UniProt Q9UHQ9  
 CYB5R1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Saliva 19199708    
Thymus 23844026    
 Gene ontology annotations for CYB5R1
Molecular Function
    cytochrome-b5 reductase activity, acting on NAD(P)H GO:0004128 TAS
    protein binding GO:0005515 IPI
    FAD binding GO:0071949 IBA
Biological Process
    bicarbonate transport GO:0015701 TAS
    sterol biosynthetic process GO:0016126 IEA
Subcellular Localization
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 HDA
    platelet alpha granule membrane GO:0031092 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CYB5R1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
7
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CYB5R1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATP6V1B2 526
Co-fractionation Homo sapiens
2 CHRNA4  
Affinity Capture-MS Homo sapiens
3 RAB1A 5861
Co-fractionation Homo sapiens
4 RXFP1  
Affinity Capture-MS Homo sapiens
5 PCDHGA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 SPATA7 55812
Co-fractionation Homo sapiens
7 ACOT9 23597
Co-fractionation Homo sapiens
8 APOE 348
Co-fractionation Homo sapiens
9 UBC 7316
Affinity Capture-MS Homo sapiens
10 MFSD8 256471
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 SLC7A14  
Affinity Capture-MS Homo sapiens
12 HEPACAM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 ATP5L 10632
Co-fractionation Homo sapiens
14 MGST1 4257
Co-fractionation Homo sapiens
15 OGDH 4967
Co-fractionation Homo sapiens
16 PRDX3 10935
Co-fractionation Homo sapiens
17 COQ9  
Affinity Capture-MS Homo sapiens
18 MRPS23 51649
Co-fractionation Homo sapiens
19 SLC31A1 1317
Affinity Capture-MS Homo sapiens
20 MARCH5  
Proximity Label-MS Homo sapiens
21 UBQLN1 29979
Two-hybrid Homo sapiens
22 ATP2A3 489
Affinity Capture-MS Homo sapiens
23 C3orf52  
Affinity Capture-MS Homo sapiens
24 SLC51B  
Two-hybrid Homo sapiens
25 PHB 5245
Co-fractionation Homo sapiens
26 HSD17B4 3295
Co-fractionation Homo sapiens
27 TMEM106A  
Affinity Capture-MS Homo sapiens
28 UBQLN4 56893
Two-hybrid Homo sapiens
29 SLC25A3 5250
Co-fractionation Homo sapiens
30 ATP5A1 498
Co-fractionation Homo sapiens
31 HIGD1C  
Two-hybrid Homo sapiens
32 NDUFA8 4702
Co-fractionation Homo sapiens
33 CHRNB2  
Affinity Capture-MS Homo sapiens
34 SLC25A20 788
Co-fractionation Homo sapiens
35 USMG5 84833
Co-fractionation Homo sapiens
36 PCDHGC4  
Affinity Capture-MS Homo sapiens
37 C1orf54  
Affinity Capture-MS Homo sapiens
38 IL20RA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 SSUH2  
Affinity Capture-MS Homo sapiens
40 OCIAD2 132299
Co-fractionation Homo sapiens
41 UQCRC1 7384
Co-fractionation Homo sapiens
42 PREB 10113
Co-fractionation Homo sapiens
43 BTNL3  
Affinity Capture-MS Homo sapiens
44 AGPS 8540
Co-fractionation Homo sapiens
45 GNG5 2787
Co-fractionation Homo sapiens
46 VDAC2 7417
Co-fractionation Homo sapiens
47 PCDHA11  
Affinity Capture-MS Homo sapiens
48 ATP5B 506
Co-fractionation Homo sapiens
49 ZACN  
Affinity Capture-MS Homo sapiens
50 SLC7A1 6541
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 NKAIN1  
Affinity Capture-MS Homo sapiens
52 ANLN 54443
Affinity Capture-MS Homo sapiens
53 CYB5B 80777
Co-fractionation Homo sapiens
54 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
55 TMEM30A 55754
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 HADHB 3032
Co-fractionation Homo sapiens
57 HADHA 3030
Co-fractionation Homo sapiens
58 TTYH1  
Affinity Capture-MS Homo sapiens
59 LRRC59 55379
Co-fractionation Homo sapiens
60 PANX1 24145
Proximity Label-MS Homo sapiens
61 LETM1 3954
Co-fractionation Homo sapiens
62 UQCRC2 7385
Co-fractionation Homo sapiens
63 MCOLN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 PDGFRA 5156
Affinity Capture-MS Homo sapiens
65 IL22RA1 58985
Affinity Capture-MS Homo sapiens
66 AQP3  
Affinity Capture-MS Homo sapiens
67 OCIAD1 54940
Proximity Label-MS Homo sapiens
68 SGTB  
Two-hybrid Homo sapiens
69 PCDHGB2  
Affinity Capture-MS Homo sapiens
70 TOMM6  
Co-fractionation Homo sapiens
71 CHRNB4  
Affinity Capture-MS Homo sapiens
72 RPA3 6119
Proximity Label-MS Homo sapiens
73 ATP2A1 487
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 SCGB2A2  
Affinity Capture-MS Homo sapiens
75 ACTB 60
Co-fractionation Homo sapiens
76 PRKY  
Affinity Capture-MS Homo sapiens
77 SGTA 6449
Two-hybrid Homo sapiens
78 NDUFA3  
Co-fractionation Homo sapiens
79 CACNG1  
Affinity Capture-MS Homo sapiens
80 SLC22A4 6583
Affinity Capture-MS Homo sapiens
81 AKAP1 8165
Proximity Label-MS Homo sapiens
82 SCCPDH 51097
Co-fractionation Homo sapiens
83 KCNA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 HTR3B  
Affinity Capture-MS Homo sapiens
85 MAGEA8  
Affinity Capture-MS Homo sapiens
86 PHB2 11331
Co-fractionation Homo sapiens
87 NAAA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 TTC1 7265
Two-hybrid Homo sapiens
89 KCNA2  
Affinity Capture-MS Homo sapiens
90 LRRC55  
Affinity Capture-MS Homo sapiens
91 PDHA1 5160
Co-fractionation Homo sapiens
92 CCR1  
Affinity Capture-MS Homo sapiens
93 TSPAN15 23555
Affinity Capture-MS Homo sapiens
94 MTCH2 23788
Proximity Label-MS Homo sapiens
95 LY6G6F 259215
Affinity Capture-MS Homo sapiens
96 SFXN1 94081
Co-fractionation Homo sapiens
97 SCN4A  
Affinity Capture-MS Homo sapiens
98 ZNRF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 RAB7A 7879
Co-fractionation Homo sapiens
100 PINK1  
Affinity Capture-MS Homo sapiens
101 CYB5R3 1727
Co-fractionation Homo sapiens
102 MARCH4  
Affinity Capture-MS Homo sapiens
103 CHRNE  
Affinity Capture-MS Homo sapiens
104 VDAC3 7419
Co-fractionation Homo sapiens
105 DERL1 79139
Proximity Label-MS Homo sapiens
106 CCT8L2  
Affinity Capture-MS Homo sapiens
107 MPV17 4358
Co-fractionation Homo sapiens
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