Gene description for CYB5R1
Gene name cytochrome b5 reductase 1
Gene symbol CYB5R1
Other names/aliases B5R.1
B5R1
B5R2
NQO3A2
humb5R2
Species Homo sapiens
 Database cross references - CYB5R1
ExoCarta ExoCarta_51706
Entrez Gene 51706
HGNC 13397
MIM 608341
UniProt Q9UHQ9  
 CYB5R1 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
Thymus 23844026    
 Gene ontology annotations for CYB5R1
Molecular Function
    cytochrome-b5 reductase activity, acting on NAD(P)H GO:0004128 IEA
    molecular_function GO:0003674 ND
    protein binding GO:0005515 IPI
Biological Process
    biological_process GO:0008150 ND
    positive regulation of protein targeting to mitochondrion GO:1903955 IMP
    oxidation-reduction process GO:0055114 IEA
    sterol biosynthetic process GO:0016126 IEA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    mitochondrion GO:0005739 IDA
    membrane GO:0016020 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified CYB5R1 in exosomes
1
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
2
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CYB5R1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CYCS  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CYB5R1 is involved
No pathways found





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