Gene description for UQCRC1
Gene name ubiquinol-cytochrome c reductase core protein I
Gene symbol UQCRC1
Other names/aliases D3S3191
Species Homo sapiens
 Database cross references - UQCRC1
ExoCarta ExoCarta_7384
Entrez Gene 7384
HGNC 12585
MIM 191328
UniProt P31930  
 UQCRC1 identified in exosomes derived from the following tissue/cell type
Melanoma cells 25950383    
 Gene ontology annotations for UQCRC1
Molecular Function
    metal ion binding GO:0046872 IEA
    ubiquitin protein ligase binding GO:0031625 IPI
    protein complex binding GO:0032403 IEA
    ubiquinol-cytochrome-c reductase activity GO:0008121 TAS
Biological Process
    mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 IEA
    oxidative phosphorylation GO:0006119 TAS
    response to alkaloid GO:0043279 IEA
    small molecule metabolic process GO:0044281 TAS
    aerobic respiration GO:0009060 TAS
    response to activity GO:0014823 IEA
    hydrogen ion transmembrane transport GO:1902600 TAS
    oxidation-reduction process GO:0055114 TAS
    cellular metabolic process GO:0044237 TAS
    respiratory electron transport chain GO:0022904 TAS
Subcellular Localization
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial respiratory chain complex III GO:0005750 IEA
    mitochondrial respiratory chain GO:0005746 TAS
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified UQCRC1 in exosomes
Experiment ID 258
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for UQCRC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DNAJA1 3301
Affinity Capture-MS Homo sapiens
2 UQCRC2 7385
Affinity Capture-MS Homo sapiens
3 RTN4 57142
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
4 RUVBL2 10856
Affinity Capture-MS Homo sapiens
5 CYCS  
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
6 SNRPF 6636
Affinity Capture-MS Homo sapiens
7 SRPRB 58477
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which UQCRC1 is involved
Respiratory electron transport TAS Reactome

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