Gene description for LETM1
Gene name leucine zipper-EF-hand containing transmembrane protein 1
Gene symbol LETM1
Other names/aliases -
Species Homo sapiens
 Database cross references - LETM1
ExoCarta ExoCarta_3954
Entrez Gene 3954
HGNC 6556
MIM 604407
UniProt O95202  
 LETM1 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for LETM1
Molecular Function
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
Biological Process
    cristae formation GO:0042407 IMP
Subcellular Localization
    mitochondrion GO:0005739 ISS
    mitochondrial inner membrane GO:0005743 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified LETM1 in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for LETM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which LETM1 is involved
No pathways found





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