Gene description for OTC
Gene name ornithine carbamoyltransferase
Gene symbol OTC
Other names/aliases OCTD
Species Homo sapiens
 Database cross references - OTC
ExoCarta ExoCarta_5009
Entrez Gene 5009
HGNC 8512
MIM 300461
UniProt P00480  
 OTC identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for OTC
Molecular Function
    ornithine carbamoyltransferase activity GO:0004585 IDA
    amino acid binding GO:0016597 IEA
    phospholipid binding GO:0005543 IEA
    phosphate ion binding GO:0042301 IEA
Biological Process
    citrulline biosynthetic process GO:0019240 IDA
    response to insulin GO:0032868 IEA
    midgut development GO:0007494 IEA
    ornithine catabolic process GO:0006593 IDA
    small molecule metabolic process GO:0044281 TAS
    ammonia homeostasis GO:0097272 IMP
    cellular nitrogen compound metabolic process GO:0034641 TAS
    liver development GO:0001889 IEA
    response to drug GO:0042493 IEA
    arginine biosynthetic process via ornithine GO:0042450 IBA
    protein homotrimerization GO:0070207 IEA
    response to zinc ion GO:0010043 IEA
    urea cycle GO:0000050 TAS
    response to biotin GO:0070781 IEA
Subcellular Localization
    mitochondrion GO:0005739 IDA
    cytoplasm GO:0005737 IBA
    mitochondrial inner membrane GO:0005743 IEA
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified OTC in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for OTC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TOMM20 9804
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which OTC is involved
Urea cycle TAS Reactome

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