ExoCarta: Gene summary

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Gene description for MRPS10
Gene name	mitochondrial ribosomal protein S10
Gene symbol	MRPS10
Other names/aliases	MRP-S10 PNAS-122
Species	Homo sapiens
Database cross references - MRPS10
ExoCarta	ExoCarta_55173
Vesiclepedia	VP_55173
Entrez Gene	55173
HGNC	14502
MIM	611976
UniProt	P82664
MRPS10 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942

Gene ontology annotations for MRPS10

Biological Process
	mitochondrial translation	GO:0032543	NAS
Subcellular Localization
	mitochondrion	GO:0005739	HTP
	mitochondrion	GO:0005739	IBA
	mitochondrial inner membrane	GO:0005743	NAS
	mitochondrial inner membrane	GO:0005743	TAS
	mitochondrial matrix	GO:0005759	TAS
	mitochondrial small ribosomal subunit	GO:0005763	IDA
	mitochondrial small ribosomal subunit	GO:0005763	NAS

Experiment description of studies that identified MRPS10 in sEVs

Experiment ID

489

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 6

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

490

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 7

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

491

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

492

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 9

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Protein-protein interactions for MRPS10

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

CDC14B

8555

Affinity Capture-MS

Homo sapiens

SNRPA

6626

Affinity Capture-MS

Homo sapiens

MRPS27

23107

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SLIRP

81892

Proximity Label-MS

Homo sapiens

FOXA1

Affinity Capture-MS

Homo sapiens

H1FNT

Affinity Capture-MS

Homo sapiens

ZNF346

Affinity Capture-MS

Homo sapiens

RPL36AL

6166

Affinity Capture-MS

Homo sapiens

HIST1H1D

3007

Affinity Capture-MS

Homo sapiens

RPL26

6154

Affinity Capture-MS

Homo sapiens

TRUB2

Proximity Label-MS

Homo sapiens

MTG2

Proximity Label-MS

Homo sapiens

NGRN

Proximity Label-MS

Homo sapiens

RPL10

6134

Affinity Capture-MS

Homo sapiens

CHCHD1

Proximity Label-MS

Homo sapiens

TLX2

Proximity Label-MS

Homo sapiens

XRN2

22803

Two-hybrid

Homo sapiens

RPUSD4

84881

Proximity Label-MS

Homo sapiens

DNAJC15

Proximity Label-MS

Homo sapiens

MTRF1

Proximity Label-MS

Homo sapiens

GFM2

84340

Proximity Label-MS

Homo sapiens

CCDC90B

Proximity Label-MS

Homo sapiens

AMOTL1

154810

Affinity Capture-MS

Homo sapiens

LRPPRC

10128

Proximity Label-MS

Homo sapiens

RPS18

6222

Co-fractionation

Homo sapiens

Lyplal1

Affinity Capture-MS

Mus musculus

NDUFS3

4722

Affinity Capture-MS

Homo sapiens

CRYZ

1429

Proximity Label-MS

Homo sapiens

TFAM

7019

Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

PMPCA

23203

Proximity Label-MS

Homo sapiens

SDHB

6390

Co-fractionation

Homo sapiens

MRPL23

6150

Co-fractionation

Homo sapiens

MRPS23

51649

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MRPS5

64969

Co-fractionation

Homo sapiens

HINT2

84681

Proximity Label-MS

Homo sapiens

DUSP11

Affinity Capture-MS

Homo sapiens

MRPS24

64951

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ZNF460

Affinity Capture-MS

Homo sapiens

RXRB

6257

Affinity Capture-MS

Homo sapiens

DDRGK1

65992

Affinity Capture-MS

Homo sapiens

C21orf33

Proximity Label-MS

Homo sapiens

RPS9

6203

Affinity Capture-MS

Homo sapiens

MRPS26

64949

Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SRSF3

6428

Affinity Capture-MS

Homo sapiens

EXD2

Proximity Label-MS

Homo sapiens

ERAL1

Affinity Capture-MS

Homo sapiens

POU5F1

Affinity Capture-MS

Homo sapiens

E4F1

Affinity Capture-MS

Homo sapiens

MRPS7

51081

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

PMPCB

9512

Proximity Label-MS

Homo sapiens

TACO1

Proximity Label-MS

Homo sapiens

FASTKD2

Proximity Label-MS

Homo sapiens

MTIF2

4528

Proximity Label-MS

Homo sapiens

RPL19

6143

Affinity Capture-MS

Homo sapiens

MTERF3

Proximity Label-MS

Homo sapiens

CTCF

Affinity Capture-MS

Homo sapiens

KIF14

9928

Affinity Capture-MS

Homo sapiens

LIN28A

Affinity Capture-MS

Homo sapiens

MDH2

4191

Proximity Label-MS

Homo sapiens

KIFC1

3833

Affinity Capture-MS

Homo sapiens

MRPS25

64432

Affinity Capture-MS

Homo sapiens

C6orf203

Proximity Label-MS

Homo sapiens

COX15

1355

Proximity Label-MS

Homo sapiens

FASTKD5

Proximity Label-MS

Homo sapiens

RPL9

6133

Co-fractionation

Homo sapiens

ZNF17

Affinity Capture-MS

Homo sapiens

RPL4

6124

Affinity Capture-MS

Homo sapiens

MRPS34

65993

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

TRA2A

29896

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

TUFM

7284

Co-fractionation		Homo sapiens
Proximity Label-MS		Homo sapiens

ZBTB48

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

HSCB

150274

Proximity Label-MS

Homo sapiens

HIST1H2AM

8336

Affinity Capture-MS

Homo sapiens

RPL35

11224

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

IGF2BP1

10642

Affinity Capture-MS

Homo sapiens

MRPL18

29074

Affinity Capture-MS

Homo sapiens

MRPS6

Affinity Capture-MS

Homo sapiens

CCDC109B

55013

Proximity Label-MS

Homo sapiens

REXO4

Affinity Capture-MS

Homo sapiens

MOV10

4343

Co-fractionation		Homo sapiens
Affinity Capture-RNA		Homo sapiens

CBX6

Affinity Capture-MS

Homo sapiens

MCU

90550

Proximity Label-MS

Homo sapiens

MTFMT

Proximity Label-MS

Homo sapiens

MRPL11

65003

Proximity Label-MS

Homo sapiens

MTRF1L

Proximity Label-MS

Homo sapiens

TMEM70

Proximity Label-MS

Homo sapiens

GLTSCR2

Affinity Capture-MS

Homo sapiens

MRPL2

51069

Affinity Capture-MS

Homo sapiens

RPL11

6135

Co-fractionation

Homo sapiens

WDR46

Affinity Capture-MS

Homo sapiens

BAG3

9531

Affinity Capture-Luminescence

Homo sapiens

CISD3

284106

Affinity Capture-MS

Homo sapiens

MRPL14

64928

Co-fractionation

Homo sapiens

PPAN

56342

Affinity Capture-MS

Homo sapiens

OTC

5009

Proximity Label-MS

Homo sapiens

RBM39

9584

Affinity Capture-MS

Homo sapiens

MRRF

Proximity Label-MS

Homo sapiens

ABT1

29777

Affinity Capture-MS

Homo sapiens

MRPS12

Proximity Label-MS

Homo sapiens

100

AURKAIP1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

101

DAP3

7818

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

102

RPS2

6187

Co-fractionation

Homo sapiens

103

BAZ1B

9031

Affinity Capture-MS

Homo sapiens

104

MRPL24

Co-fractionation

Homo sapiens

105

RC3H2

Affinity Capture-MS

Homo sapiens

106

CLPP

8192

Proximity Label-MS

Homo sapiens

107

MRPS11

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

108

MTIF3

Proximity Label-MS

Homo sapiens

109

SRSF4

6429

Affinity Capture-MS

Homo sapiens

110

SRSF5

6430

Affinity Capture-MS

Homo sapiens

111

MRPS14

Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens

112

RPS6

6194

Affinity Capture-MS

Homo sapiens

113

RMND1

55005

Proximity Label-MS

Homo sapiens

114

HNRNPA1

3178

Affinity Capture-MS

Homo sapiens

115

DHX30

22907

Proximity Label-MS

Homo sapiens

116

RPL7L1

285855

Affinity Capture-MS

Homo sapiens

117

NXF1

10482

Affinity Capture-RNA

Homo sapiens

118

MRPS28

Affinity Capture-MS

Homo sapiens

119

ZNF512

Affinity Capture-MS

Homo sapiens

120

C12orf65

Proximity Label-MS

Homo sapiens

121

MYCN

Affinity Capture-MS

Homo sapiens

122

PRR3

Affinity Capture-MS

Homo sapiens

123

CUL9

Affinity Capture-MS

Homo sapiens

124

RBM42

Affinity Capture-MS

Homo sapiens

125

MTG1

Proximity Label-MS

Homo sapiens

126

MYC

Affinity Capture-MS

Homo sapiens

127

Hnrnpa3

229279

Affinity Capture-MS

Mus musculus

128

SET

6418

Affinity Capture-MS

Homo sapiens

129

NOL12

79159

Affinity Capture-MS

Homo sapiens

130

TSFM

10102

Proximity Label-MS

Homo sapiens

131

ACAD9

28976

Proximity Label-MS

Homo sapiens

132

AMOT

154796

Affinity Capture-MS

Homo sapiens

133

RPL18

6141

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

134

VWA8

23078

Proximity Label-MS

Homo sapiens

135

MRPS17

51373

Affinity Capture-MS

Homo sapiens

136

METTL15

Proximity Label-MS

Homo sapiens

137

ZC3H3

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

138

MCUR1

63933

Proximity Label-MS

Homo sapiens

139

RBMS2

5939

Affinity Capture-MS

Homo sapiens

140

ZNF574

Affinity Capture-MS

Homo sapiens

141

RPL13

6137

Affinity Capture-MS

Homo sapiens

142

YBX1

4904

Affinity Capture-MS

Homo sapiens

143

1431

Proximity Label-MS

Homo sapiens

144

ZNF707

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

145

PLEKHA4

57664

Affinity Capture-MS

Homo sapiens

146

RC3H1

149041

Affinity Capture-MS

Homo sapiens

147

AUH

549

Proximity Label-MS

Homo sapiens

148

ILF3

3609

Co-fractionation

Homo sapiens

149

DNAJC19

131118

Proximity Label-MS

Homo sapiens

150

MCAT

27349

Affinity Capture-MS

Homo sapiens

151

MRPS2

51116

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

152

RPL6

6128

Affinity Capture-MS

Homo sapiens

153

ICT1

3396

Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

154

APOBEC3D

Affinity Capture-MS

Homo sapiens

155

LONP1

9361

Proximity Label-MS

Homo sapiens

156

SRP14

6727

Affinity Capture-MS

Homo sapiens

157

MRPS18C

Affinity Capture-MS

Homo sapiens

158

MRPS31

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

159

ZNF777

Affinity Capture-MS

Homo sapiens

160

MRPS15

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

161

ELAVL1

1994

Affinity Capture-RNA

Homo sapiens

162

SHMT2

6472

Affinity Capture-RNA

Homo sapiens

163

RPS5

6193

Co-fractionation

Homo sapiens

164

SSBP1

6742

Proximity Label-MS

Homo sapiens

165

KLF12

Affinity Capture-MS

Homo sapiens

166

FASTKD3

Proximity Label-MS

Homo sapiens

167

KRR1

11103

Affinity Capture-MS

Homo sapiens

168

NEIL1

Affinity Capture-MS

Homo sapiens

169

MRPS18B

28973

Affinity Capture-MS

Homo sapiens

170

GFM1

85476

Proximity Label-MS

Homo sapiens

171

HNRNPL

3191

Affinity Capture-MS

Homo sapiens

172

SNRNP70

6625

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

173

TEFM

Proximity Label-MS

Homo sapiens

174

GLI4

Affinity Capture-MS

Homo sapiens

175

RPUSD3

Proximity Label-MS

Homo sapiens

176

TBRG4

9238

Proximity Label-MS

Homo sapiens

177

TRMT10B

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

178

GRSF1

2926

Proximity Label-MS

Homo sapiens

179

C1QBP

708

Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

180

RPL23A

6147

Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens

181

HNRNPU

3192

Affinity Capture-MS

Homo sapiens

182

C17orf80

55028

Proximity Label-MS

Homo sapiens

183

METTL17

Proximity Label-MS

Homo sapiens

184

C8orf82

Proximity Label-MS

Homo sapiens

185

SRSF7

6432

Affinity Capture-MS

Homo sapiens

186

REPIN1

Affinity Capture-MS

Homo sapiens

187

MRPS9

64965

Affinity Capture-MS

Homo sapiens

View the network

Pathways in which MRPS10 is involved

Pathway	Evidence	Source
Metabolism of proteins	TAS	Reactome
Metabolism of proteins	IEA	Reactome
Mitochondrial protein degradation	TAS	Reactome
Mitochondrial translation	TAS	Reactome
Mitochondrial translation	IEA	Reactome
Mitochondrial translation elongation	TAS	Reactome
Mitochondrial translation elongation	IEA	Reactome
Mitochondrial translation initiation	IEA	Reactome
Mitochondrial translation termination	TAS	Reactome
Translation	TAS	Reactome
Translation	IEA	Reactome

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