Gene description for MRPL18
Gene name mitochondrial ribosomal protein L18
Gene symbol MRPL18
Other names/aliases HSPC071
L18mt
MRP-L18
Species Homo sapiens
 Database cross references - MRPL18
ExoCarta ExoCarta_29074
Entrez Gene 29074
HGNC 14477
MIM 611831
UniProt Q9H0U6  
 MRPL18 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for MRPL18
Molecular Function
    5S rRNA binding GO:0008097 IDA
    structural constituent of ribosome GO:0003735 NAS
Biological Process
    mitochondrial translational termination GO:0070126 TAS
    mitochondrial translational elongation GO:0070125 TAS
    translation GO:0006412 NAS
    mitochondrial translational initiation GO:0070124 TAS
    organelle organization GO:0006996 TAS
    mitochondrial translation GO:0032543 TAS
    rRNA import into mitochondrion GO:0035928 IDA
Subcellular Localization
    extracellular space GO:0005615 IDA
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrion GO:0005739 IDA
    mitochondrial ribosome GO:0005761 NAS
 Experiment description of studies that identified MRPL18 in exosomes
1
Experiment ID 234
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for MRPL18
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here