Gene description for MAEA
Gene name macrophage erythroblast attacher
Gene symbol MAEA
Other names/aliases EMLP
EMP
GID9
HLC-10
PIG5
Species Homo sapiens
 Database cross references - MAEA
ExoCarta ExoCarta_10296
Vesiclepedia VP_10296
Entrez Gene 10296
HGNC 13731
MIM 606801
UniProt Q7L5Y9  
 MAEA identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for MAEA
Molecular Function
    actin binding GO:0003779 IDA
    ubiquitin-protein transferase activity GO:0004842 IBA
    metal ion binding GO:0046872 IEA
    ubiquitin protein ligase activity GO:0061630 IEA
Biological Process
    cytoskeleton organization GO:0007010 IEA
    cell adhesion GO:0007155 IDA
    regulation of mitotic cell cycle GO:0007346 NAS
    negative regulation of myeloid cell apoptotic process GO:0033033 IDA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    erythrocyte maturation GO:0043249 IEA
    enucleate erythrocyte development GO:0048822 IEA
    cell division GO:0051301 IEA
Subcellular Localization
    ubiquitin ligase complex GO:0000151 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    spindle GO:0005819 IDA
    actomyosin contractile ring GO:0005826 IDA
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IDA
    plasma membrane GO:0005886 IDA
    nuclear matrix GO:0016363 IDA
    GID complex GO:0034657 IBA
 Experiment description of studies that identified MAEA in exosomes
1
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MAEA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SFRP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 CLIP1 6249
Co-fractionation Homo sapiens
5 SKI 6497
Affinity Capture-MS Homo sapiens
6 DDX17 10521
Affinity Capture-MS Homo sapiens
7 MYOC 4653
Two-hybrid Homo sapiens
8 MPO 4353
Affinity Capture-MS Homo sapiens
9 KIF20A 10112
Affinity Capture-MS Homo sapiens
10 CDK5RAP1  
Affinity Capture-MS Homo sapiens
11 UBC 7316
Affinity Capture-MS Homo sapiens
12 WDR26 80232
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
13 WBP5  
Affinity Capture-MS Homo sapiens
14 GSK3A 2931
Two-hybrid Homo sapiens
15 IL17F  
Affinity Capture-MS Homo sapiens
16 YPEL5 51646
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 TRIM28 10155
Affinity Capture-MS Homo sapiens
18 RANBP10 57610
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 LECT2  
Affinity Capture-MS Homo sapiens
20 PRC1 9055
Affinity Capture-MS Homo sapiens
21 MRPS24 64951
Affinity Capture-MS Homo sapiens
22 GCG  
Affinity Capture-MS Homo sapiens
23 FTSJ2 29960
Affinity Capture-MS Homo sapiens
24 OBSL1 23363
Affinity Capture-MS Homo sapiens
25 MKLN1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
26 TULP3 7289
Affinity Capture-MS Homo sapiens
27 TCEB3B  
Affinity Capture-MS Homo sapiens
28 PTPN14 5784
Affinity Capture-MS Homo sapiens
29 C6orf15  
Affinity Capture-MS Homo sapiens
30 ARHGAP22 58504
Affinity Capture-MS Homo sapiens
31 MRPL4 51073
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 KCTD6  
Affinity Capture-MS Homo sapiens
33 FAS 355
Proximity Label-MS Homo sapiens
34 C15orf59  
Affinity Capture-MS Homo sapiens
35 CALR3  
Affinity Capture-MS Homo sapiens
36 PARK2  
Affinity Capture-MS Homo sapiens
37 ARMC8 25852
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
38 KRBA1  
Affinity Capture-MS Homo sapiens
39 GDF15 9518
Affinity Capture-MS Homo sapiens
40 CHRDL2 25884
Affinity Capture-MS Homo sapiens
41 ACTA1 58
Affinity Capture-MS Homo sapiens
42 Ypel5  
Affinity Capture-MS Mus musculus
43 GID8 54994
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 CCDC51 79714
Affinity Capture-MS Homo sapiens
45 CHMP4B 128866
Affinity Capture-MS Homo sapiens
46 SPAG11A  
Affinity Capture-MS Homo sapiens
47 DDX5 1655
Affinity Capture-MS Homo sapiens
48 TIGD5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 EMILIN3  
Affinity Capture-MS Homo sapiens
50 LYPD1  
Affinity Capture-MS Homo sapiens
51 MB21D1  
Proximity Label-MS Homo sapiens
52 TDGF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 WNT10A  
Affinity Capture-MS Homo sapiens
54 ADAMTS1 9510
Affinity Capture-MS Homo sapiens
55 INSL6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 LCA5  
Affinity Capture-MS Homo sapiens
57 NEU4  
Affinity Capture-MS Homo sapiens
58 BACH2 60468
Affinity Capture-MS Homo sapiens
59 TMEM70  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 RMND5A 64795
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
61 EBI3 10148
Affinity Capture-MS Homo sapiens
62 GPS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 MMP13  
Affinity Capture-MS Homo sapiens
64 LY6H  
Affinity Capture-MS Homo sapiens
65 HLA-DPB1 3115
Affinity Capture-MS Homo sapiens
66 MMP7 4316
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 CBFA2T3  
Affinity Capture-MS Homo sapiens
68 PRG3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 PIGT 51604
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 GID4  
Affinity Capture-MS Homo sapiens
71 JPH4 84502
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 POTEI 653269
Affinity Capture-MS Homo sapiens
73 ECT2 1894
Affinity Capture-MS Homo sapiens
74 LILRB4  
Affinity Capture-MS Homo sapiens
75 CCDC120  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 DDX50 79009
Affinity Capture-MS Homo sapiens
77 CST8  
Affinity Capture-MS Homo sapiens
78 PMCH  
Affinity Capture-MS Homo sapiens
79 PRG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 CUL3 8452
Affinity Capture-MS Homo sapiens
81 COQ4  
Affinity Capture-MS Homo sapiens
82 SPON1 10418
Affinity Capture-MS Homo sapiens
83 IKZF1  
Affinity Capture-MS Homo sapiens
84 HTRA3 94031
Affinity Capture-MS Homo sapiens
85 DUSP6 1848
Affinity Capture-MS Homo sapiens
86 HTRA2 27429
Affinity Capture-MS Homo sapiens
87 AURKB 9212
Affinity Capture-MS Homo sapiens
88 CTSG 1511
Affinity Capture-MS Homo sapiens
89 RANBP9 10048
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
90 HAPLN3 145864
Affinity Capture-MS Homo sapiens
91 CORO2A  
Affinity Capture-MS Homo sapiens
92 GNLY  
Affinity Capture-MS Homo sapiens
93 BMP1 649
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 MRPL38  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 FLOT1 10211
Co-fractionation Homo sapiens
96 NCKAP5  
Affinity Capture-MS Homo sapiens
97 TNNT1  
Affinity Capture-MS Homo sapiens
98 GPT 2875
Affinity Capture-MS Homo sapiens
99 PRICKLE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 UCK2 7371
Affinity Capture-MS Homo sapiens
101 GRK5 2869
Affinity Capture-MS Homo sapiens
102 EFHC2  
Affinity Capture-MS Homo sapiens
103 PDGFD 80310
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 NMB  
Affinity Capture-MS Homo sapiens
105 TLE1 7088
Affinity Capture-MS Homo sapiens
106 RMND5B  
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
107 PRMT1 3276
Affinity Capture-MS Homo sapiens
108 HBP1  
Affinity Capture-Western Homo sapiens
109 SUCLA2 8803
Affinity Capture-MS Homo sapiens
110 DDX58 23586
Affinity Capture-RNA Homo sapiens
111 MRPL18 29074
Affinity Capture-MS Homo sapiens
112 TLE4  
Affinity Capture-MS Homo sapiens
113 RAB8A 4218
Affinity Capture-MS Homo sapiens
114 TRIM37  
Proximity Label-MS Homo sapiens
115 TEFM  
Affinity Capture-MS Homo sapiens
116 ZG16B 124220
Affinity Capture-MS Homo sapiens
117 GLIPR1L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 SPINK7  
Affinity Capture-MS Homo sapiens
119 GDNF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 C9orf72  
Affinity Capture-MS Homo sapiens
121 TNNT3  
Affinity Capture-MS Homo sapiens
122 NDUFS6  
Affinity Capture-MS Homo sapiens
123 GREM2 64388
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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