Gene description for MAEA
Gene name macrophage erythroblast attacher
Gene symbol MAEA
Other names/aliases EMLP
EMP
GID9
HLC-10
PIG5
Species Homo sapiens
 Database cross references - MAEA
ExoCarta ExoCarta_10296
Entrez Gene 10296
HGNC 13731
MIM 606801
UniProt Q7L5Y9  
 MAEA identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for MAEA
Molecular Function
    actin binding GO:0003779 IDA
Biological Process
    negative regulation of myeloid cell apoptotic process GO:0033033 IDA
    enucleate erythrocyte development GO:0048822 IEA
    cell adhesion GO:0007155 IDA
    cell cycle GO:0007049 IEA
    cytoskeleton organization GO:0007010 IEA
    cell division GO:0051301 IEA
    erythrocyte maturation GO:0043249 IEA
    regulation of mitotic cell cycle GO:0007346 NAS
Subcellular Localization
    nuclear matrix GO:0016363 IDA
    cytoplasm GO:0005737 IDA
    cytoskeleton GO:0005856 IDA
    integral component of plasma membrane GO:0005887 IDA
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 IDA
    actomyosin contractile ring GO:0005826 IDA
    spindle GO:0005819 IDA
 Experiment description of studies that identified MAEA in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for MAEA
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MAEA is involved
No pathways found





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