Gene description for UCK2
Gene name uridine-cytidine kinase 2
Gene symbol UCK2
Other names/aliases TSA903
Species Homo sapiens
 Database cross references - UCK2
ExoCarta ExoCarta_7371
Entrez Gene 7371
HGNC 12562
MIM 609329
UniProt Q9BZX2  
 UCK2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for UCK2
Molecular Function
    nucleoside kinase activity GO:0019206 EXP
    uridine kinase activity GO:0004849 IEA
    ATP binding GO:0005524 IEA
Biological Process
    pyrimidine nucleoside salvage GO:0043097 TAS
    phosphorylation GO:0016310 IEA
    response to axon injury GO:0048678 IEA
    CMP salvage GO:0006238 IEA
    nucleobase-containing small molecule metabolic process GO:0055086 TAS
    pyrimidine nucleobase metabolic process GO:0006206 TAS
    small molecule metabolic process GO:0044281 TAS
    UMP salvage GO:0044206 IEA
    CTP salvage GO:0044211 IEA
    cellular response to oxygen levels GO:0071453 IEA
    feeding behavior GO:0007631 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    cellular_component GO:0005575 ND
    intracellular membrane-bounded organelle GO:0043231 IEA
 Experiment description of studies that identified UCK2 in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for UCK2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which UCK2 is involved
Pyrimidine salvage reactions TAS Reactome

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