Gene description for UBC
Gene name	ubiquitin C
Gene symbol	UBC
Other names/aliases	HMG20
Species	Homo sapiens
Database cross references - UBC
ExoCarta	ExoCarta_7316
Entrez Gene	7316
HGNC	12468
MIM	191340
UniProt	P0CG48
UBC identified in exosomes derived from the following tissue/cell type
Breast milk	17641064
Colorectal cancer cells	17956143
Colorectal cancer cells	19837982
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723
Hepatocytes	26054723
Melanoma cells	22635005
Neuroblastoma cells	25944692
Platelets	25332113
Platelets	25332113
Platelets	25332113
Prostate cancer cells	25844599
Prostate cancer cells	25844599
Saliva	19199708
Thymus	23844026
Tracheobronchial cells	19190083

Gene ontology annotations for UBC

Molecular Function     protease binding GO:0002020 IPI     protein binding GO:0005515 IPI     poly(A) RNA binding GO:0044822 IDA Biological Process     carbohydrate metabolic process GO:0005975 TAS     mitotic cell cycle GO:0000278 TAS     G2/M transition of mitotic cell cycle GO:0000086 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition GO:0051437 TAS     negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 TAS     circadian rhythm GO:0007623 TAS     apoptotic process GO:0006915 TAS     viral process GO:0016032 TAS     transforming growth factor beta receptor signaling pathway GO:0007179 TAS     gene expression GO:0010467 TAS     Notch signaling pathway GO:0007219 TAS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     virion assembly GO:0019068 TAS     regulation of apoptotic process GO:0042981 TAS     nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 TAS     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     endosomal transport GO:0016197 TAS     ubiquitin homeostasis GO:0010992 IEA     toll-like receptor 2 signaling pathway GO:0034134 TAS     epidermal growth factor receptor signaling pathway GO:0007173 TAS     transmembrane transport GO:0055085 TAS     cellular response to hypoxia GO:0071456 TAS     viral protein processing GO:0019082 TAS     glucose metabolic process GO:0006006 TAS     negative regulation of transcription from RNA polymerase II promoter GO:0000122 TAS     energy homeostasis GO:0097009 IEA     apoptotic signaling pathway GO:0097190 TAS     positive regulation of apoptotic process GO:0043065 TAS     cytokine-mediated signaling pathway GO:0019221 TAS     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     toll-like receptor 3 signaling pathway GO:0034138 TAS     negative regulation of canonical Wnt signaling pathway GO:0090090 TAS     ion transmembrane transport GO:0034220 TAS     female meiosis I GO:0007144 IEA     female gonad development GO:0008585 IEA     I-kappaB kinase/NF-kappaB signaling GO:0007249 TAS     toll-like receptor 5 signaling pathway GO:0034146 TAS     intracellular transport of virus GO:0075733 TAS     positive regulation of canonical Wnt signaling pathway GO:0090263 TAS     glycogen biosynthetic process GO:0005978 TAS     viral life cycle GO:0019058 TAS     toll-like receptor 4 signaling pathway GO:0034142 TAS     programmed necrotic cell death GO:0097300 TAS     error-prone translesion synthesis GO:0042276 TAS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 TAS     translesion synthesis GO:0019985 TAS     antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042590 TAS     antigen processing and presentation of peptide antigen via MHC class I GO:0002474 TAS     necroptotic process GO:0070266 TAS     toll-like receptor signaling pathway GO:0002224 TAS     toll-like receptor 10 signaling pathway GO:0034166 TAS     Notch receptor processing GO:0007220 TAS     positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 TAS     G1/S transition of mitotic cell cycle GO:0000082 TAS     transcription, DNA-templated GO:0006351 TAS     activation of MAPK activity GO:0000187 TAS     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051439 TAS     regulation of type I interferon production GO:0032479 TAS     nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0035872 TAS     negative regulation of type I interferon production GO:0032480 TAS     DNA repair GO:0006281 TAS     negative regulation of apoptotic process GO:0043066 TAS     membrane organization GO:0061024 TAS     JNK cascade GO:0007254 TAS     T cell receptor signaling pathway GO:0050852 TAS     innate immune response GO:0045087 TAS     antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 TAS     negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 TAS     hypothalamus gonadotrophin-releasing hormone neuron development GO:0021888 IEA     error-free translesion synthesis GO:0070987 TAS     seminiferous tubule development GO:0072520 IEA     anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 TAS     positive regulation of type I interferon production GO:0032481 TAS     regulation of necrotic cell death GO:0010939 TAS     male meiosis I GO:0007141 IEA     protein polyubiquitination GO:0000209 TAS     transcription initiation from RNA polymerase II promoter GO:0006367 TAS     DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 TAS     programmed cell death GO:0012501 TAS     fat pad development GO:0060613 IEA     stress-activated MAPK cascade GO:0051403 TAS     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS     toll-like receptor 9 signaling pathway GO:0034162 TAS     small molecule metabolic process GO:0044281 TAS     regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 TAS     negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051436 TAS     DNA damage response, detection of DNA damage GO:0042769 TAS     positive regulation of NF-kappaB transcription factor activity GO:0051092 TAS     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS Subcellular Localization     endosome membrane GO:0010008 TAS     cytosol GO:0005829 TAS     plasma membrane GO:0005886 TAS     nucleoplasm GO:0005654 TAS     extracellular exosome GO:0070062 IDA     endocytic vesicle membrane GO:0030666 TAS