Gene description for SFPQ
Gene name splicing factor proline/glutamine-rich
Gene symbol SFPQ
Other names/aliases POMP100
PPP1R140
PSF
Species Homo sapiens
 Database cross references - SFPQ
ExoCarta ExoCarta_6421
Vesiclepedia VP_6421
Entrez Gene 6421
HGNC 10774
MIM 605199
UniProt P23246  
 SFPQ identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Melanoma cells 25950383    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Neuroblastoma cells 25944692    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
Squamous carcinoma cells 20124223    
T lymphocytes 34108659    
Thymus 23844026    
 Gene ontology annotations for SFPQ
Molecular Function
    transcription cis-regulatory region binding GO:0000976 ISS
    DNA binding GO:0003677 IDA
    chromatin binding GO:0003682 ISS
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IBA
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IPI
    histone deacetylase binding GO:0042826 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 IGI
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    alternative mRNA splicing, via spliceosome GO:0000380 IBA
    alternative mRNA splicing, via spliceosome GO:0000380 IMP
    double-strand break repair via homologous recombination GO:0000724 IMP
    activation of innate immune response GO:0002218 IDA
    chromatin remodeling GO:0006338 ISS
    regulation of DNA-templated transcription GO:0006355 IBA
    mRNA processing GO:0006397 TAS
    RNA splicing GO:0008380 TAS
    regulation of circadian rhythm GO:0042752 ISS
    negative regulation of circadian rhythm GO:0042754 ISS
    innate immune response GO:0045087 IEA
    negative regulation of DNA-templated transcription GO:0045892 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    rhythmic process GO:0048511 IEA
    positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902177 IDA
Subcellular Localization
    chromatin GO:0000785 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 TAS
    nuclear matrix GO:0016363 IDA
    nuclear speck GO:0016607 IEA
    paraspeckles GO:0042382 IDA
    RNA polymerase II transcription regulator complex GO:0090575 ISS
 Experiment description of studies that identified SFPQ in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
7
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
10
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
11
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
12
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
13
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
18
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
21
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
22
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
23
Experiment ID 259
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
24
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
25
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
26
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
27
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
28
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
29
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
30
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
31
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
32
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
33
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
34
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
35
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
36
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
37
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
38
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
39
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SFPQ
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
Affinity Capture-MS Homo sapiens
2 SLFN11 91607
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 UBE2H 7328
Affinity Capture-MS Homo sapiens
5 HNRNPC 3183
Co-fractionation Homo sapiens
6 FOXC1  
Affinity Capture-MS Homo sapiens
7 CTTN 2017
Two-hybrid Homo sapiens
8 FAM98A 25940
Affinity Capture-MS Homo sapiens
9 HDAC2 3066
Affinity Capture-Western Homo sapiens
10 CFAP97  
Affinity Capture-MS Homo sapiens
11 TIMM23B  
Co-fractionation Homo sapiens
12 IDH1 3417
Co-fractionation Homo sapiens
13 EEF1G 1937
Co-fractionation Homo sapiens
14 POT1  
Affinity Capture-MS Homo sapiens
15 PCF11 51585
Co-fractionation Homo sapiens
16 TOP2B 7155
Co-fractionation Homo sapiens
17 PPIL4  
Affinity Capture-MS Homo sapiens
18 CEP55 55165
Two-hybrid Homo sapiens
19 RPA2 6118
Affinity Capture-MS Homo sapiens
20 DDX17 10521
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
21 EBNA-LP  
Affinity Capture-Western
Affinity Capture-MS
22 RBMXL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 TSG101 7251
Affinity Capture-MS Homo sapiens
24 KIF20A 10112
Affinity Capture-MS Homo sapiens
25 SMC3 9126
Co-fractionation Homo sapiens
26 UBC 7316
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
27 Rxra  
Reconstituted Complex Mus musculus
28 UQCRC2 7385
Co-fractionation Homo sapiens
29 HNRNPR 10236
Co-fractionation Homo sapiens
30 APBB1  
Reconstituted Complex Homo sapiens
31 PRPF40A 55660
Reconstituted Complex Homo sapiens
32 PARK7 11315
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
33 RPS6KB2  
Affinity Capture-MS Homo sapiens
34 GCN1L1 10985
Co-fractionation Homo sapiens
35 SNRPD2 6633
Co-fractionation Homo sapiens
36 HSPA5 3309
Co-fractionation Homo sapiens
37 ANKRD50 57182
Affinity Capture-MS Homo sapiens
38 CAPRIN1 4076
Co-fractionation Homo sapiens
39 APEX1 328
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
40 KIAA1429 25962
Affinity Capture-MS Homo sapiens
41 PER2  
Proximity Label-MS Homo sapiens
42 DDX23 9416
Co-fractionation Homo sapiens
43 PARK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 WDR76  
Affinity Capture-MS Homo sapiens
45 PGK1 5230
Co-fractionation Homo sapiens
46 PFKL 5211
Co-fractionation Homo sapiens
47 UTP14A 10813
Co-fractionation Homo sapiens
48 EXOSC2 23404
Affinity Capture-MS Homo sapiens
49 PRC1 9055
Affinity Capture-MS Homo sapiens
50 DYRK1A 1859
Affinity Capture-MS Homo sapiens
51 KIF23 9493
Affinity Capture-MS Homo sapiens
52 MCM2 4171
Affinity Capture-MS Homo sapiens
53 LOC100506753  
Affinity Capture-RNA Homo sapiens
Co-fractionation Homo sapiens
54 SF3B1 23451
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
55 COPS5 10987
Affinity Capture-MS Homo sapiens
56 FBXW7  
Affinity Capture-MS Homo sapiens
57 AI837181  
Affinity Capture-MS Mus musculus
58 C8orf82  
Proximity Label-MS Homo sapiens
59 NCOA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 CPSF7 79869
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
61 NUP210 23225
Co-fractionation Homo sapiens
62 SRRM2 23524
Affinity Capture-MS Homo sapiens
63 KHDRBS1 10657
Co-fractionation Homo sapiens
64 DDRGK1 65992
Affinity Capture-MS Homo sapiens
65 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
66 OBSL1 23363
Affinity Capture-MS Homo sapiens
67 EWSR1 2130
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 KRT31 3881
Two-hybrid Homo sapiens
69 ORC6  
Affinity Capture-MS Homo sapiens
70 ZCCHC3  
Affinity Capture-MS Homo sapiens
71 ITGA4 3676
Affinity Capture-MS Homo sapiens
72 EED  
Affinity Capture-MS Homo sapiens
73 SLX4  
Affinity Capture-MS Homo sapiens
74 U2AF1 7307
Co-fractionation Homo sapiens
75 NR2C1  
Affinity Capture-MS Homo sapiens
76 TOMM40 10452
Co-fractionation Homo sapiens
77 SFN 2810
Affinity Capture-MS Homo sapiens
78 NEAT1  
Affinity Capture-RNA Homo sapiens
Co-fractionation Homo sapiens
79 ZC3HAV1 56829
Co-fractionation Homo sapiens
80 SMAD5 4090
Two-hybrid Homo sapiens
81 SON 6651
Co-fractionation Homo sapiens
82 MYCN  
Affinity Capture-MS Homo sapiens
83 SERBP1 26135
Co-fractionation Homo sapiens
84 STAT6 6778
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
85 SREK1 140890
Affinity Capture-MS Homo sapiens
86 TFIP11  
Two-hybrid Homo sapiens
87 RBM14 10432
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
88 MSH2 4436
Co-fractionation Homo sapiens
89 KIF14 9928
Affinity Capture-MS Homo sapiens
90 HSPA8 3312
Co-fractionation Homo sapiens
91 DMRTB1  
Two-hybrid Homo sapiens
92 Cstf2t  
Two-hybrid Mus musculus
93 RBMX 27316
Co-fractionation Homo sapiens
94 MAPK1 5594
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
95 HEXIM1 10614
Affinity Capture-MS Homo sapiens
96 CHMP4C 92421
Affinity Capture-MS Homo sapiens
97 PFKM 5213
Co-fractionation Homo sapiens
98 PPP1CA 5499
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
99 WBP4  
Reconstituted Complex Homo sapiens
100 TMEM14B  
Affinity Capture-MS Homo sapiens
101 SCP2 6342
Co-fractionation Homo sapiens
102 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
103 DDX21 9188
Co-fractionation Homo sapiens
104 CRY1  
Affinity Capture-MS Homo sapiens
105 PRKCI 5584
Affinity Capture-Western Homo sapiens
106 CUL4B 8450
Affinity Capture-MS Homo sapiens
107 PITX3  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
108 CTBP1 1487
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
109 PEG10 23089
Affinity Capture-MS Homo sapiens
110 MEPCE 56257
Affinity Capture-MS Homo sapiens
111 SRSF3 6428
Co-fractionation Homo sapiens
112 TOPORS  
Affinity Capture-MS Homo sapiens
113 RBM7  
Affinity Capture-MS Homo sapiens
114 NONO 4841
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
115 STAU1 6780
Affinity Capture-MS Homo sapiens
116 CWC15  
Co-fractionation Homo sapiens
117 VRK1 7443
Affinity Capture-MS Homo sapiens
118 UBE2I 7329
Biochemical Activity Homo sapiens
119 PTP4A3  
Affinity Capture-MS Homo sapiens
120 CD2BP2 10421
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
121 SRSF7 6432
Co-fractionation Homo sapiens
122 TIMM9  
Co-fractionation Homo sapiens
123 CHMP4B 128866
Affinity Capture-MS Homo sapiens
124 YWHAE 7531
Affinity Capture-MS Homo sapiens
125 VCP 7415
Affinity Capture-MS Homo sapiens
126 DDX5 1655
Co-fractionation Homo sapiens
127 NTRK1 4914
Affinity Capture-MS Homo sapiens
128 HN1 51155
Two-hybrid Homo sapiens
129 STAG2 10735
Co-fractionation Homo sapiens
130 IFI16 3428
Affinity Capture-MS Homo sapiens
131 Mki67 17345
Affinity Capture-MS Mus musculus
132 YLPM1 56252
Affinity Capture-MS Homo sapiens
133 EXOSC5 56915
Two-hybrid Homo sapiens
134 PARP1 142
Proximity Label-MS Homo sapiens
135 DPH5 51611
Co-fractionation Homo sapiens
136 CCDC8  
Affinity Capture-MS Homo sapiens
137 Mapk13  
Affinity Capture-MS Mus musculus
138 CBLL1  
Affinity Capture-Western Homo sapiens
139 Nono 53610
Co-purification Mus musculus
Two-hybrid Mus musculus
140 BTK 695
Affinity Capture-MS Homo sapiens
141 SRSF4 6429
Co-fractionation Homo sapiens
142 ACTC1 70
Proximity Label-MS Homo sapiens
143 EFTUD2 9343
Co-fractionation Homo sapiens
144 HNRNPA3 220988
Co-fractionation Homo sapiens
145 HDAC5 10014
Affinity Capture-MS Homo sapiens
146 Cpsf6  
Two-hybrid Mus musculus
147 CEBPA  
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
148 RAD21 5885
Affinity Capture-Western Homo sapiens
149 ASB18  
Affinity Capture-MS Homo sapiens
150 CARS 833
Co-fractionation Homo sapiens
151 SP100 6672
Affinity Capture-MS Homo sapiens
152 SMARCC2 6601
Affinity Capture-MS Homo sapiens
153 KDF1  
Affinity Capture-MS Homo sapiens
154 SP1  
Affinity Capture-Western Homo sapiens
155 SCARNA22  
Affinity Capture-RNA Homo sapiens
156 TPR 7175
Co-fractionation Homo sapiens
157 TRIM21 6737
Affinity Capture-MS Homo sapiens
158 VCAM1 7412
Affinity Capture-MS Homo sapiens
159 HNRNPD 3184
Co-fractionation Homo sapiens
160 RPL23A 6147
Affinity Capture-MS Homo sapiens
161 SFPQ 6421
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
162 FAM76B  
Affinity Capture-MS Homo sapiens
163 Lin7c 22343
Affinity Capture-MS Mus musculus
164 PSMA3 5684
Affinity Capture-MS Homo sapiens
165 RPS19 6223
Affinity Capture-MS Homo sapiens
166 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
167 DNAJC21  
Affinity Capture-MS Homo sapiens
168 DZIP3  
Affinity Capture-MS Homo sapiens
169 FANCD2  
Affinity Capture-MS Homo sapiens
170 SF1 7536
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
171 METTL14  
Affinity Capture-MS Homo sapiens
172 MUS81  
Synthetic Growth Defect Homo sapiens
173 ACE2 59272
Affinity Capture-MS Homo sapiens
174 SF3B2 10992
Co-fractionation Homo sapiens
175 SMARCD1 6602
Affinity Capture-Western Homo sapiens
176 RAB13 5872
Affinity Capture-MS Homo sapiens
177 SMARCA5 8467
Co-fractionation Homo sapiens
178 FXR1 8087
Affinity Capture-MS Homo sapiens
179 SIRT7  
Affinity Capture-MS Homo sapiens
180 PPARG 5468
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
181 LMO7 4008
Co-fractionation Homo sapiens
182 HTATSF1 27336
Co-fractionation Homo sapiens
183 CTNNB1 1499
Affinity Capture-MS Homo sapiens
184 SRSF5 6430
Co-fractionation Homo sapiens
185 U2AF2 11338
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
186 CD274 29126
Affinity Capture-MS Homo sapiens
187 VTN 7448
Co-fractionation Homo sapiens
188 Rbm14  
Two-hybrid Mus musculus
189 CUL3 8452
Affinity Capture-MS Homo sapiens
190 NR3C1 2908
Affinity Capture-Western Homo sapiens
191 BTF3 689
Affinity Capture-MS Homo sapiens
192 CSNK2A1 1457
Biochemical Activity Homo sapiens
193 DTX2 113878
Proximity Label-MS Homo sapiens
194 PRPF19 27339
Co-fractionation Homo sapiens
195 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
196 FUS 2521
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
197 RBM27  
Affinity Capture-MS Homo sapiens
198 TSPYL5  
Affinity Capture-MS Homo sapiens
199 MYC  
Affinity Capture-MS Homo sapiens
200 ASB3 51130
Affinity Capture-MS Homo sapiens
201 HIP1R 9026
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
202 SLTM 79811
Co-fractionation Homo sapiens
203 HIST3H3 8290
Protein-peptide Homo sapiens
204 FN1 2335
Affinity Capture-MS Homo sapiens
205 NXF1 10482
Affinity Capture-RNA Homo sapiens
206 AP2M1 1173
Affinity Capture-MS Homo sapiens
207 SF3A1 10291
Co-fractionation Homo sapiens
208 RAD51D  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Synthetic Growth Defect Homo sapiens
209 ASB12  
Affinity Capture-MS Homo sapiens
210 IMMT 10989
Co-fractionation Homo sapiens
211 CDK2 1017
Affinity Capture-MS Homo sapiens
212 PCBP1 5093
Affinity Capture-MS Homo sapiens
213 EXOSC8  
Two-hybrid Homo sapiens
214 TADA2A  
Affinity Capture-MS Homo sapiens
215 TRIM68 55128
Affinity Capture-MS Homo sapiens
216 PSPC1 55269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
217 RPA3 6119
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
218 VIM 7431
Two-hybrid Homo sapiens
219 ACAT1 38
Co-fractionation Homo sapiens
220 EGFR 1956
Affinity Capture-MS Homo sapiens
Negative Genetic Homo sapiens
221 PRRC2A 7916
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
222 DHPS 1725
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
223 TOP1 7150
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
224 PHF5A 84844
Co-fractionation Homo sapiens
225 RPA4  
Proximity Label-MS Homo sapiens
226 NDC80 10403
Affinity Capture-MS Homo sapiens
227 PPP1R10  
Affinity Capture-MS Homo sapiens
228 DDB1 1642
Co-fractionation Homo sapiens
229 CUL7 9820
Affinity Capture-MS Homo sapiens
230 SMARCA2 6595
Affinity Capture-Western Homo sapiens
231 MMADHC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
232 SF3B3 23450
Co-fractionation Homo sapiens
233 IKZF3  
Affinity Capture-MS Homo sapiens
234 Rpl35 66489
Affinity Capture-MS Mus musculus
235 Ewsr1 14030
Two-hybrid Mus musculus
236 Cxxc1  
Affinity Capture-MS Mus musculus
237 GAS7  
Reconstituted Complex Homo sapiens
238 FHL2 2274
Two-hybrid Homo sapiens
239 ZMYM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
240 UQCRFS1P1  
Co-fractionation Homo sapiens
241 MDM2  
Affinity Capture-MS Homo sapiens
242 DHX57 90957
Affinity Capture-MS Homo sapiens
243 HUWE1 10075
Affinity Capture-MS Homo sapiens
244 RPS16 6217
Affinity Capture-MS Homo sapiens
245 EEF1A1 1915
Co-fractionation Homo sapiens
246 Thra  
Reconstituted Complex Mus musculus
247 SART1 9092
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
248 AHSA1 10598
Affinity Capture-MS Homo sapiens
249 EXOSC10 5394
Affinity Capture-MS Homo sapiens
250 RNF43  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
251 NUDT21 11051
Affinity Capture-MS Homo sapiens
252 EIF3F 8665
Affinity Capture-MS Homo sapiens
253 ARRB2 409
Affinity Capture-MS Homo sapiens
254 NR4A2  
Affinity Capture-Western Homo sapiens
255 MKRN1 23608
Affinity Capture-MS Homo sapiens
256 SPOP  
Affinity Capture-MS Homo sapiens
257 METTL17  
Affinity Capture-MS Homo sapiens
258 SMN1 6606
Affinity Capture-MS Homo sapiens
259 SND1 27044
Co-fractionation Homo sapiens
260 YTHDF2 51441
Co-fractionation Homo sapiens
261 ILF3 3609
Co-fractionation Homo sapiens
262 DNAJC19 131118
Co-fractionation Homo sapiens
263 SRRM1 10250
Affinity Capture-MS Homo sapiens
264 TP53 7157
Affinity Capture-MS Homo sapiens
265 SIN3A  
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
266 WWOX 51741
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
267 TCERG1 10915
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
268 WBP11  
Co-fractionation Homo sapiens
269 Sin3a  
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
270 PIN1 5300
Reconstituted Complex Homo sapiens
271 C1orf123 54987
Affinity Capture-MS Homo sapiens
272 SMARCC1 6599
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
273 Tsc1  
Affinity Capture-MS Mus musculus
274 PRRC2C 23215
Affinity Capture-MS Homo sapiens
275 RPA1 6117
Affinity Capture-MS Homo sapiens
276 LSM14A 26065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
277 HNRNPA2B1 3181
Co-fractionation Homo sapiens
278 SNRPA 6626
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
279 SSR4 6748
Co-fractionation Homo sapiens
280 TIMM10  
Co-fractionation Homo sapiens
281 HNRNPM 4670
Co-fractionation Homo sapiens
282 PTBP1 5725
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
283 THRAP3 9967
Co-fractionation Homo sapiens
284 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
285 HDAC1 3065
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
286 PRMT5 10419
Affinity Capture-MS Homo sapiens
287 ZNF746  
Affinity Capture-MS Homo sapiens
288 NUP35 129401
Proximity Label-MS Homo sapiens
289 DDX58 23586
Affinity Capture-RNA Homo sapiens
290 TARS 6897
Co-fractionation Homo sapiens
291 MYBBP1A 10514
Affinity Capture-MS Homo sapiens
292 TJP1 7082
Co-fractionation Homo sapiens
293 UNK  
Affinity Capture-RNA Homo sapiens
294 ESR1  
Reconstituted Complex Homo sapiens
295 OGT 8473
Reconstituted Complex Homo sapiens
296 UFL1 23376
Affinity Capture-MS Homo sapiens
297 LONP1 9361
Affinity Capture-MS Homo sapiens
298 ZNF768 79724
Affinity Capture-MS Homo sapiens
299 XRCC6 2547
Co-fractionation Homo sapiens
300 TXN 7295
Co-fractionation Homo sapiens
301 IKZF1  
Affinity Capture-MS Homo sapiens
302 MCM5 4174
Affinity Capture-MS Homo sapiens
303 MOV10 4343
Affinity Capture-RNA Homo sapiens
304 ALYREF 10189
Affinity Capture-MS Homo sapiens
305 HNRNPL 3191
Co-fractionation Homo sapiens
306 SF3B4 10262
Two-hybrid Homo sapiens
307 CYCS 54205
Affinity Capture-MS Homo sapiens
308 CYLD  
Affinity Capture-MS Homo sapiens
309 TRIM31  
Affinity Capture-MS Homo sapiens
310 PINK1  
Affinity Capture-MS Homo sapiens
311 COX5A 9377
Co-fractionation Homo sapiens
312 SH3KBP1 30011
Co-fractionation Homo sapiens
313 METTL3  
Affinity Capture-MS Homo sapiens
314 DIDO1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
315 NDUFS3 4722
Co-fractionation Homo sapiens
316 DDX42 11325
Affinity Capture-MS Homo sapiens
317 ERG  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
318 EIF5A 1984
Affinity Capture-MS Homo sapiens
319 SNW1 22938
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
320 KRAS 3845
Synthetic Growth Defect Homo sapiens
Negative Genetic Homo sapiens
321 HNRNPU 3192
Co-fractionation Homo sapiens
322 C9orf72  
Affinity Capture-MS Homo sapiens
323 AR 367
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
324 NUFIP2 57532
Affinity Capture-MS Homo sapiens
325 RAC1 5879
Two-hybrid Homo sapiens
326 RC3H1 149041
Affinity Capture-MS Homo sapiens
327 ATXN3 4287
Affinity Capture-MS Homo sapiens
328 SNRPA1 6627
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
329 Pspc1  
Two-hybrid Mus musculus
330 PPARGC1A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
331 PRMT1 3276
Affinity Capture-MS Homo sapiens
332 CPSF6 11052
Co-fractionation Homo sapiens
333 MECP2 4204
Affinity Capture-MS Homo sapiens
334 EP300 2033
Affinity Capture-MS Homo sapiens
335 CDC5L 988
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
336 SP3  
Affinity Capture-Western Homo sapiens
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Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here