Gene description for PCF11
Gene name PCF11 cleavage and polyadenylation factor subunit
Gene symbol PCF11
Other names/aliases -
Species Homo sapiens
 Database cross references - PCF11
ExoCarta ExoCarta_51585
Entrez Gene 51585
HGNC 30097
MIM 608876
UniProt O94913  
 PCF11 identified in exosomes derived from the following tissue/cell type
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for PCF11
Molecular Function
    mRNA binding GO:0003729 IBA
    RNA polymerase II core binding GO:0000993 IBA
Biological Process
    transcription from RNA polymerase II promoter GO:0006366 TAS
    mRNA polyadenylation GO:0006378 IBA
    RNA splicing GO:0008380 TAS
    gene expression GO:0010467 TAS
    mRNA cleavage GO:0006379 NAS
    mRNA splicing, via spliceosome GO:0000398 TAS
    termination of RNA polymerase II transcription GO:0006369 TAS
    mRNA 3'-end processing GO:0031124 TAS
Subcellular Localization
    mRNA cleavage factor complex GO:0005849 NAS
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified PCF11 in exosomes
1
Experiment ID 196
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 197
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PCF11
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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