Gene description for PLRG1
Gene name pleiotropic regulator 1
Gene symbol PLRG1
Other names/aliases Cwc1
PRL1
PRP46
PRPF46
TANGO4
Species Homo sapiens
 Database cross references - PLRG1
ExoCarta ExoCarta_5356
Entrez Gene 5356
HGNC 9089
MIM 605961
UniProt O43660  
 PLRG1 identified in exosomes derived from the following tissue/cell type
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for PLRG1
Molecular Function
    protein binding GO:0005515 IPI
    signal transducer activity GO:0004871 TAS
    transcription corepressor activity GO:0003714 TAS
Biological Process
    signal transduction GO:0007165 TAS
    protein localization to nucleus GO:0034504 IEA
    positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IEA
    RNA splicing GO:0008380 TAS
    mRNA splicing, via spliceosome GO:0000398 TAS
    gene expression GO:0010467 TAS
    negative regulation of nucleic acid-templated transcription GO:1903507 TAS
Subcellular Localization
    catalytic step 2 spliceosome GO:0071013 IDA
    nucleus GO:0005634 TAS
    nuclear speck GO:0016607 IEA
    DNA replication factor A complex GO:0005662 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified PLRG1 in exosomes
1
Experiment ID 196
ISEV standards
✔
EM
EV Biophysical techniques
✔
Alix|TSG101|HSP70
EV Cytosolic markers
✔
CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 197
ISEV standards
✔
EM
EV Biophysical techniques
✔
Alix|TSG101|HSP70
EV Cytosolic markers
✔
CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PLRG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BCAS2 10286
Affinity Capture-MS Homo sapiens
2 PRPF19 27339
Affinity Capture-MS Homo sapiens
3 CPVL  
Affinity Capture-MS Homo sapiens
4 CDC5L 988
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PLRG1 is involved
PathwayEvidenceSource
mRNA Splicing - Major Pathway TAS Reactome





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