Gene description for CHD8
Gene name	chromodomain helicase DNA binding protein 8
Gene symbol	CHD8
Other names/aliases	AUTS18 HELSNF1
Species	Homo sapiens
Database cross references - CHD8
ExoCarta	ExoCarta_57680
Entrez Gene	57680
HGNC	20153
MIM	610528
UniProt	Q9HCK8
CHD8 identified in exosomes derived from the following tissue/cell type
Hepatocytes	26054723

Gene ontology annotations for CHD8

Molecular Function     p53 binding GO:0002039 ISS     DNA-dependent ATPase activity GO:0008094 IDA     armadillo repeat domain binding GO:0070016 IEA     chromatin binding GO:0003682 IDA     beta-catenin binding GO:0008013 IDA     DNA binding GO:0003677 IMP     DNA helicase activity GO:0003678 IMP     histone binding GO:0042393 ISS     methylated histone binding GO:0035064 IDA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IDA Biological Process     negative regulation of Wnt signaling pathway GO:0030178 IDA     negative regulation of transcription, DNA-templated GO:0045892 IMP     positive regulation of transcription from RNA polymerase III promoter GO:0045945 IMP     digestive tract development GO:0048565 IMP     negative regulation of fibroblast apoptotic process GO:2000270 IEA     transcription, DNA-templated GO:0006351 IEA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP     brain development GO:0007420 IMP     negative regulation of canonical Wnt signaling pathway GO:0090090 IDA     DNA duplex unwinding GO:0032508 IMP     ATP-dependent chromatin remodeling GO:0043044 IMP     canonical Wnt signaling pathway GO:0060070 IDA     in utero embryonic development GO:0001701 IEA     positive regulation of transcription, DNA-templated GO:0045893 IDA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP Subcellular Localization     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 TAS     protein complex GO:0043234 IDA     MLL1 complex GO:0071339 IDA