Gene description for AR
Gene name androgen receptor
Gene symbol AR
Other names/aliases AIS
DHTR
HUMARA
HYSP1
KD
NR3C4
SBMA
SMAX1
TFM
Species Homo sapiens
 Database cross references - AR
ExoCarta ExoCarta_367
Entrez Gene 367
HGNC 644
MIM 313700
UniProt P10275  
 AR identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for AR
Molecular Function
    RNA polymerase II transcription factor binding GO:0001085 IPI
    beta-catenin binding GO:0008013 TAS
    receptor binding GO:0005102 IPI
    androgen binding GO:0005497 NAS
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
    transcription regulatory region DNA binding GO:0044212 IDA
    chromatin binding GO:0003682 IDA
    ATPase binding GO:0051117 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA
    transcription factor binding GO:0008134 IPI
    zinc ion binding GO:0008270 IEA
    enzyme binding GO:0019899 IPI
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    DNA binding GO:0003677 NAS
    androgen receptor activity GO:0004882 TAS
    protein dimerization activity GO:0046983 NAS
    protein binding GO:0005515 IPI
    ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0004879 IDA
Biological Process
    steroid hormone mediated signaling pathway GO:0043401 IEA
    cell proliferation GO:0008283 NAS
    intracellular receptor signaling pathway GO:0030522 IDA
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IDA
    transcription initiation from RNA polymerase II promoter GO:0006367 TAS
    transcription, DNA-templated GO:0006351 IDA
    prostate gland development GO:0030850 NAS
    signal transduction GO:0007165 TAS
    sex differentiation GO:0007548 NAS
    regulation of establishment of protein localization to plasma membrane GO:0090003 IDA
    protein oligomerization GO:0051259 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP
    positive regulation of phosphorylation GO:0042327 IMP
    positive regulation of cell proliferation GO:0008284 IDA
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    cell growth GO:0016049 NAS
    positive regulation of transcription from RNA polymerase III promoter GO:0045945 IDA
    negative regulation of integrin biosynthetic process GO:0045720 IDA
    androgen receptor signaling pathway GO:0030521 IDA
    transport GO:0006810 TAS
    small GTPase mediated signal transduction GO:0007264 TAS
    gene expression GO:0010467 TAS
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IMP
    positive regulation of integrin biosynthetic process GO:0045726 IDA
    cell-cell signaling GO:0007267 TAS
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 TAS
    protein complex GO:0043234 IDA
    nuclear chromatin GO:0000790 IDA
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified AR in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for AR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GTF2F1 2962
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
2 NCOA6  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 HDAC4  
Reconstituted Complex Homo sapiens
4 CCNH  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
5 HDAC1 3065
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
6 SNURF  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
7 AES 166
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
8 SVIL  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
9 SP1  
Affinity Capture-Western Homo sapiens
10 BRCA1 672
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Invitro Homo sapiens
11 CDK7  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
12 TSG101 7251
Two-hybrid Homo sapiens
13 CDC25B 994
Invitro Homo sapiens
14 CALM1 801
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
15 GTF2F2  
Invitro Homo sapiens
16 POU2F1  
Reconstituted Complex Homo sapiens
17 HSPA1A 3303
Affinity Capture-Western Homo sapiens
18 PRKDC 5591
Affinity Capture-MS Homo sapiens
19 GSK3A 2931
Affinity Capture-Western Homo sapiens
20 KAT7  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
21 IL6ST 3572
Affinity Capture-Western Homo sapiens
22 HDAC3 8841
Reconstituted Complex Homo sapiens
23 NCOR1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Phenotypic Suppression Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
24 ZMIZ1 57178
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
25 TP53  
Biochemical Activity Homo sapiens
Phenotypic Suppression Homo sapiens
26 NR2C2  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
27 SRC 6714
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
28 STAT3 6774
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
29 TDG 6996
Reconstituted Complex Homo sapiens
30 NCOA3  
Affinity Capture-Western Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
31 TIF1  
Invitro Homo sapiens
32 SPDEF  
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
33 NR2C1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
34 TGFB1I1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
35 FHL2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
36 NSD1  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
37 RNF4  
Invivo Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
38 GSK3B 2932
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
39 NCOA1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
40 MAPK1 5594
Reconstituted Complex Homo sapiens
41 RB1 5925
Reconstituted Complex Homo sapiens
Invitro Homo sapiens
42 PRPF6 24148
Invivo Homo sapiens
43 FOXA1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
44 PIAS4  
Reconstituted Complex Homo sapiens
45 NCOR2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
46 NONO 4841
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
47 RAD9A  
Two-hybrid Homo sapiens
48 UBE2I 7329
Affinity Capture-Western Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Phenotypic Enhancement Homo sapiens
49 SMARCA4 6597
Affinity Capture-Western Homo sapiens
50 GTF2H1 2965
Invivo Homo sapiens
Invitro Homo sapiens
51 RAN 5901
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
52 PTEN  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
53 PIAS2  
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
54 YWHAQ 10971
Reconstituted Complex Homo sapiens
55 SRY  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
56 PELP1 27043
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
57 MYBBP1A 10514
Invitro Homo sapiens
58 CEBPA  
Reconstituted Complex Homo sapiens
59 DAXX  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
60 NCOA4 8031
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
61 RNF14  
Protein-peptide Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
62 TMF1 7110
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Far Western Homo sapiens
63 PA2G4 5036
Invivo Homo sapiens
Invitro Homo sapiens
64 COX5B 1329
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
65 NISCH 11188
Invivo Homo sapiens
Invitro Homo sapiens
66 CDK9 1025
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
67 MAGEA11  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
68 NR0B2  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
69 CTNNB1 1499
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
70 DAP3  
Reconstituted Complex Homo sapiens
71 CRSP2  
Invivo Homo sapiens
72 CALR 811
Invivo Homo sapiens
Invitro Homo sapiens
73 NR3C1 2908
Invitro Homo sapiens
Two-hybrid Homo sapiens
74 CCNE1  
Affinity Capture-Western Homo sapiens
75 EGFR 1956
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Co-localization Homo sapiens
76 JUN 3725
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
77 RANBP9 10048
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
78 SMAD3  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
79 BAG1 573
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
80 SELENBP1 8991
Affinity Capture-Western Homo sapiens
81 KAT5  
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
82 DCC  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
83 SART3 9733
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
84 RAF1 5894
Co-purification Homo sapiens
85 FLJ23588  
Affinity Capture-Western Homo sapiens
86 POU2F2 5452
Reconstituted Complex Homo sapiens
87 AKT1 207
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
88 CCND1 595
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
89 GRIP1  
Two-hybrid Homo sapiens
90 XRCC5 7520
Reconstituted Complex Homo sapiens
91 GSN 2934
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
92 NR0B1  
Affinity Capture-Western Homo sapiens
93 HMGB1 3146
Invivo Homo sapiens
Invitro Homo sapiens
94 XRCC6 2547
Affinity Capture-Western Homo sapiens
95 SMARCC1 6599
Affinity Capture-Western Homo sapiens
96 RCHY1  
Invitro Homo sapiens
Two-hybrid Homo sapiens
97 CDC37 11140
Reconstituted Complex Homo sapiens
98 NCOA2 10499
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
99 HNF4A  
Co-localization Homo sapiens
100 SMAD4  
Invivo Homo sapiens
Invitro Homo sapiens
101 CREBBP  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Phenotypic Suppression Homo sapiens
102 FOXO1A  
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Far Western Homo sapiens
103 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
Invitro Homo sapiens
104 ESR1  
Invitro Homo sapiens
105 TCF4  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
106 GAPDH 2597
Invitro Homo sapiens
Two-hybrid Homo sapiens
107 SLC25A4 291
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
108 EFCAB6  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
109 FLNA 2316
Two-hybrid Homo sapiens
110 PPARBP  
Invivo Homo sapiens
Invitro Homo sapiens
111 RAC3 5881
Invivo Homo sapiens
Invitro Homo sapiens
112 CEBPB  
Reconstituted Complex Homo sapiens
113 GNB2L1 10399
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
114 AR 367
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Protein-peptide Homo sapiens
Protein-peptide Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Protein-peptide Homo sapiens
Protein-peptide Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
115 PSPC1 55269
Affinity Capture-MS Homo sapiens
116 PRMT1 3276
Reconstituted Complex Homo sapiens
117 CAV1 857
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
118 PAK6 56924
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
119 UXT  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
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