Gene description for AR
Gene name	androgen receptor
Gene symbol	AR
Other names/aliases	AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM
Species	Homo sapiens
Database cross references - AR
ExoCarta	ExoCarta_367
Vesiclepedia	VP_367
Entrez Gene	367
HGNC	644
MIM	313700
UniProt	P10275
AR identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for AR

Molecular Function     transcription cis-regulatory region binding GO:0000976 IDA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA     RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IEA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA     RNA polymerase II general transcription initiation factor binding GO:0001091 IPI     transcription coactivator binding GO:0001223 IDA     transcription coactivator binding GO:0001223 IPI     DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA     chromatin binding GO:0003682 IDA     DNA-binding transcription factor activity GO:0003700 IDA     nuclear receptor activity GO:0004879 IBA     nuclear receptor activity GO:0004879 IDA     nuclear receptor activity GO:0004879 IDA     nuclear receptor activity GO:0004879 IMP     nuclear receptor activity GO:0004879 TAS     G protein-coupled receptor activity GO:0004930 IC     signaling receptor binding GO:0005102 IPI     steroid binding GO:0005496 IEA     androgen binding GO:0005497 IDA     protein binding GO:0005515 IPI     beta-catenin binding GO:0008013 IDA     beta-catenin binding GO:0008013 IPI     beta-catenin binding GO:0008013 TAS     zinc ion binding GO:0008270 IEA     enzyme binding GO:0019899 IPI     estrogen response element binding GO:0034056 IBA     ATPase binding GO:0051117 IDA     molecular adaptor activity GO:0060090 IDA     RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI     POU domain binding GO:0070974 IEA     molecular condensate scaffold activity GO:0140693 IDA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IMP     MAPK cascade GO:0000165 IEA     in utero embryonic development GO:0001701 IEA     regulation of systemic arterial blood pressure GO:0003073 IEA     epithelial cell morphogenesis GO:0003382 IEA     transcription by RNA polymerase II GO:0006366 IEA     signal transduction GO:0007165 TAS     G protein-coupled receptor signaling pathway GO:0007186 IEA     cell-cell signaling GO:0007267 TAS     spermatogenesis GO:0007283 IEA     single fertilization GO:0007338 IEA     positive regulation of cell population proliferation GO:0008284 IDA     negative regulation of cell population proliferation GO:0008285 IMP     male gonad development GO:0008584 IBA     positive regulation of gene expression GO:0010628 IDA     positive regulation of gene expression GO:0010628 IMP     male somatic sex determination GO:0019102 IEA     nuclear receptor-mediated steroid hormone signaling pathway GO:0030518 IBA     estrogen receptor signaling pathway GO:0030520 IDA     androgen receptor signaling pathway GO:0030521 IDA     androgen receptor signaling pathway GO:0030521 IDA     intracellular receptor signaling pathway GO:0030522 IDA     positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 IEA     Leydig cell differentiation GO:0033327 IEA     multicellular organism growth GO:0035264 IEA     positive regulation of phosphorylation GO:0042327 IMP     positive regulation of MAPK cascade GO:0043410 IEA     positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 IEA     positive regulation of cell differentiation GO:0045597 IMP     negative regulation of integrin biosynthetic process GO:0045720 IDA     positive regulation of integrin biosynthetic process GO:0045726 IDA     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IBA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     positive regulation of transcription by RNA polymerase III GO:0045945 IDA     insulin-like growth factor receptor signaling pathway GO:0048009 IEA     regulation of developmental growth GO:0048638 IEA     animal organ formation GO:0048645 IEA     male genitalia morphogenesis GO:0048808 IEA     epithelial cell proliferation GO:0050673 IEA     negative regulation of epithelial cell proliferation GO:0050680 IEA     positive regulation of NF-kappaB transcription factor activity GO:0051092 IMP     morphogenesis of an epithelial fold GO:0060571 IEA     lateral sprouting involved in mammary gland duct morphogenesis GO:0060599 IEA     regulation of prostatic bud formation GO:0060685 IEA     prostate gland growth GO:0060736 IEA     prostate gland epithelium morphogenesis GO:0060740 IEA     epithelial cell differentiation involved in prostate gland development GO:0060742 IEA     tertiary branching involved in mammary gland duct morphogenesis GO:0060748 IEA     mammary gland alveolus development GO:0060749 IEA     positive regulation of epithelial cell proliferation involved in prostate gland development GO:0060769 IEA     cellular response to steroid hormone stimulus GO:0071383 IMP     cellular response to estrogen stimulus GO:0071391 IDA     cellular response to testosterone stimulus GO:0071394 IDA     seminiferous tubule development GO:0072520 IEA     membraneless organelle assembly GO:0140694 IDA     positive regulation of miRNA transcription GO:1902895 IDA     regulation of protein localization to plasma membrane GO:1903076 IDA     negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IDA Subcellular Localization     chromatin GO:0000785 IBA     chromatin GO:0000785 IDA     chromatin GO:0000785 ISA     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IDA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IMP     nuclear speck GO:0016607 IDA     protein-containing complex GO:0032991 IDA