Gene description for TAF6L
Gene name TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
Gene symbol TAF6L
Other names/aliases PAF65A
Species Homo sapiens
 Database cross references - TAF6L
ExoCarta ExoCarta_10629
Entrez Gene 10629
HGNC 17305
MIM 602946
UniProt Q9Y6J9  
 TAF6L identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TAF6L
Molecular Function
    histone acetyltransferase activity GO:0004402 IDA
    transcription coactivator activity GO:0003713 IDA
    protein heterodimerization activity GO:0046982 IEA
    DNA binding GO:0003677 TAS
    protein binding GO:0005515 IPI
Biological Process
    histone H3 acetylation GO:0043966 IDA
    regulation of transcription from RNA polymerase II promoter GO:0006357 TAS
    chromatin organization GO:0006325 TAS
    DNA-templated transcription, initiation GO:0006352 IEA
    regulation of sequence-specific DNA binding transcription factor activity GO:0051090 IEA
    chromatin remodeling GO:0006338 TAS
Subcellular Localization
    histone deacetylase complex GO:0000118 TAS
    extracellular exosome GO:0070062 IDA
    STAGA complex GO:0030914 IDA
 Experiment description of studies that identified TAF6L in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for TAF6L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MYC  
Co-purification Homo sapiens
2 STX11 8676
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TAF6L is involved
PathwayEvidenceSource
HATs acetylate histones TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here