Gene description for MYH7
Gene name myosin, heavy chain 7, cardiac muscle, beta
Gene symbol MYH7
Other names/aliases CMD1S
CMH1
MPD1
MYHCB
SPMD
SPMM
Species Homo sapiens
 Database cross references - MYH7
ExoCarta ExoCarta_4625
Entrez Gene 4625
HGNC 7577
MIM 160760
UniProt P12883  
 MYH7 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Thymus 23844026    
 Gene ontology annotations for MYH7
Molecular Function
    actin binding GO:0003779 IEA
    microfilament motor activity GO:0000146 NAS
    actin-dependent ATPase activity GO:0030898 IMP
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    calmodulin binding GO:0005516 IEA
    ATPase activity GO:0016887 IDA
Biological Process
    regulation of heart rate GO:0002027 IDA
    ATP metabolic process GO:0046034 IDA
    skeletal muscle contraction GO:0003009 IMP
    cardiac muscle contraction GO:0060048 IMP
    muscle contraction GO:0006936 TAS
    muscle filament sliding GO:0030049 IMP
    regulation of slow-twitch skeletal muscle fiber contraction GO:0031449 IMP
    striated muscle contraction GO:0006941 IDA
    ventricular cardiac muscle tissue morphogenesis GO:0055010 IMP
    regulation of the force of skeletal muscle contraction GO:0014728 IMP
    adult heart development GO:0007512 IMP
    regulation of the force of heart contraction GO:0002026 IDA
Subcellular Localization
    stress fiber GO:0001725 IEA
    myosin filament GO:0032982 IDA
    muscle myosin complex GO:0005859 TAS
    cytoplasm GO:0005737 IDA
    myosin complex GO:0016459 TAS
    sarcomere GO:0030017 TAS
    nucleoplasm GO:0005654 IDA
    Z disc GO:0030018 IEA
    focal adhesion GO:0005925 IDA
 Experiment description of studies that identified MYH7 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MYH7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NTHL1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MYH7 is involved
PathwayEvidenceSource
Translocation of GLUT4 to the plasma membrane TAS Reactome





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