Gene description for ACTN2
Gene name	actinin, alpha 2
Gene symbol	ACTN2
Other names/aliases	CMD1AA CMH23
Species	Homo sapiens
Database cross references - ACTN2
ExoCarta	ExoCarta_88
Entrez Gene	88
HGNC	164
MIM	102573
UniProt	P35609
ACTN2 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	17956143
Mesenchymal stem cells	Unpublished / Not applicable
Neuroblastoma cells	25944692
Squamous carcinoma cells	20124223

Gene ontology annotations for ACTN2

Molecular Function     ion channel binding GO:0044325 IPI     calcium ion binding GO:0005509 IEA     FATZ binding GO:0051373 IDA     integrin binding GO:0005178 TAS     thyroid hormone receptor coactivator activity GO:0030375 IEA     titin Z domain binding GO:0070080 IPI     protein dimerization activity GO:0046983 IDA     identical protein binding GO:0042802 IPI     protein binding GO:0005515 IPI     actin filament binding GO:0051015 IEA     LIM domain binding GO:0030274 IEA     titin binding GO:0031432 IPI     cytoskeletal protein binding GO:0008092 IDA     structural constituent of muscle GO:0008307 TAS Biological Process     blood coagulation GO:0007596 TAS     negative regulation of potassium ion transmembrane transporter activity GO:1901017 IMP     platelet degranulation GO:0002576 TAS     muscle filament sliding GO:0030049 TAS     regulation of nucleic acid-templated transcription GO:1903506 IEA     cell adhesion GO:0007155 TAS     synaptic transmission GO:0007268 TAS     negative regulation of potassium ion transport GO:0043267 IMP     focal adhesion assembly GO:0048041 IMP     microspike assembly GO:0030035 IDA     positive regulation of potassium ion transport GO:0043268 IDA     platelet activation GO:0030168 TAS     regulation of membrane potential GO:0042391 IMP     regulation of apoptotic process GO:0042981 NAS     positive regulation of potassium ion transmembrane transporter activity GO:1901018 IDA     protein homotetramerization GO:0051289 IDA     positive regulation of receptor activity GO:2000273 IEA     negative regulation of protein localization to cell surface GO:2000009 IMP Subcellular Localization     focal adhesion GO:0005925 IMP     cytoskeleton GO:0005856 NAS     actin filament GO:0005884 TAS     platelet alpha granule lumen GO:0031093 TAS     Z disc GO:0030018 IDA     pseudopodium GO:0031143 TAS     extracellular region GO:0005576 TAS     cytosol GO:0005829 TAS     filopodium GO:0030175 IDA     extracellular exosome GO:0070062 IDA     dendritic spine GO:0043197 TAS     cortical actin cytoskeleton GO:0030864 IEA