Gene description for ATXN2
Gene name ataxin 2
Gene symbol ATXN2
Other names/aliases ASL13
ATX2
SCA2
TNRC13
Species Homo sapiens
 Database cross references - ATXN2
ExoCarta ExoCarta_6311
Vesiclepedia VP_6311
Entrez Gene 6311
HGNC 10555
MIM 601517
UniProt Q99700  
 ATXN2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ATXN2
Molecular Function
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 NAS
    mRNA binding GO:0003729 IBA
    epidermal growth factor receptor binding GO:0005154 IPI
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of receptor internalization GO:0002091 IMP
    regulation of translation GO:0006417 NAS
    RNA metabolic process GO:0016070 NAS
    P-body assembly GO:0033962 IMP
    stress granule assembly GO:0034063 IBA
    stress granule assembly GO:0034063 IMP
    RNA transport GO:0050658 NAS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    Golgi apparatus GO:0005794 IDA
    trans-Golgi network GO:0005802 IDA
    cytosol GO:0005829 IDA
    cytoplasmic stress granule GO:0010494 IBA
    cytoplasmic stress granule GO:0010494 IDA
    membrane GO:0016020 HDA
    perinuclear region of cytoplasm GO:0048471 IDA
    ribonucleoprotein complex GO:1990904 IDA
 Experiment description of studies that identified ATXN2 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ATXN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPL11 6135
Affinity Capture-MS Homo sapiens
2 NUPL2 11097
Affinity Capture-MS Homo sapiens
3 UBE2H 7328
Affinity Capture-MS Homo sapiens
4 ISG15 9636
Affinity Capture-MS Homo sapiens
5 KHDRBS3  
Co-fractionation Homo sapiens
6 FAM98A 25940
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 RBPMS 11030
Affinity Capture-MS Homo sapiens
8 CCT5 22948
Co-fractionation Homo sapiens
9 DCP1B  
Affinity Capture-MS Homo sapiens
10 EIF2S3 1968
Affinity Capture-MS Homo sapiens
11 TARDBP 23435
Co-fractionation Homo sapiens
12 FMR1 2332
Affinity Capture-MS Homo sapiens
13 RPA2 6118
Proximity Label-MS Homo sapiens
14 P4HA2 8974
Affinity Capture-MS Homo sapiens
15 DDX17 10521
Co-fractionation Homo sapiens
16 EPB41L5 57669
Affinity Capture-MS Homo sapiens
17 TSG101 7251
Affinity Capture-MS Homo sapiens
18 RPL10 6134
Affinity Capture-MS Homo sapiens
19 C15orf41  
Affinity Capture-MS Homo sapiens
20 SLC25A48  
Affinity Capture-MS Homo sapiens
21 EIF4A1 1973
Affinity Capture-MS Homo sapiens
22 VHL  
Affinity Capture-MS Homo sapiens
23 CAND1 55832
Affinity Capture-MS Homo sapiens
24 HNRNPR 10236
Co-fractionation Homo sapiens
25 LOXL4 84171
Affinity Capture-MS Homo sapiens
26 MSI1  
Affinity Capture-MS Homo sapiens
27 GSPT1 2935
Affinity Capture-MS Homo sapiens
28 HNRNPUL2 221092
Affinity Capture-MS Homo sapiens
29 CAPZB 832
Affinity Capture-MS Homo sapiens
30 PARK2  
Affinity Capture-Western Homo sapiens
31 RPS20 6224
Proximity Label-MS Homo sapiens
32 GSPT2 23708
Affinity Capture-MS Homo sapiens
33 GMPR 2766
Co-fractionation Homo sapiens
34 EMILIN1 11117
Affinity Capture-MS Homo sapiens
35 B3GNT2 10678
Affinity Capture-MS Homo sapiens
36 EDC3 80153
Affinity Capture-MS Homo sapiens
37 ACTN1 87
Two-hybrid Homo sapiens
38 TRNAU1AP  
Affinity Capture-MS Homo sapiens
39 ATXN2L 11273
Affinity Capture-MS Homo sapiens
40 CARD8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 METAP2 10988
Affinity Capture-MS Homo sapiens
42 DRG1 4733
Affinity Capture-MS Homo sapiens
43 MDC1  
Affinity Capture-MS Homo sapiens
44 KHDRBS1 10657
Co-fractionation Homo sapiens
45 GUSBP5  
Affinity Capture-MS Homo sapiens
46 KLHL33  
Affinity Capture-MS Homo sapiens
47 OAZ3  
Affinity Capture-MS Homo sapiens
48 CHGB 1114
Two-hybrid Homo sapiens
49 ESRP1 54845
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 SRP68 6730
Affinity Capture-MS Homo sapiens
51 DDX6 1656
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 EIF3B 8662
Affinity Capture-MS Homo sapiens
53 LPXN 9404
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 CCNDBP1 23582
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 MYCN  
Affinity Capture-MS Homo sapiens
56 RBM42  
Affinity Capture-MS Homo sapiens
57 GNB2L1 10399
Affinity Capture-MS Homo sapiens
58 PABPC4 8761
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
59 RPL19 6143
Affinity Capture-MS Homo sapiens
60 GFI1B  
Two-hybrid Homo sapiens
61 RBM8A 9939
Affinity Capture-MS Homo sapiens
62 LARP4B 23185
Affinity Capture-MS Homo sapiens
63 LSM12 124801
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
64 TPT1 7178
Affinity Capture-MS Homo sapiens
65 CPEB1  
Proximity Label-MS Homo sapiens
66 EDC4 23644
Affinity Capture-MS Homo sapiens
67 VRK3 51231
Affinity Capture-MS Homo sapiens
68 SULT1C4  
Affinity Capture-MS Homo sapiens
69 SH3GL3  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
70 GMDS 2762
Co-fractionation Homo sapiens
71 FHL3 2275
Affinity Capture-MS Homo sapiens
72 ABCE1 6059
Affinity Capture-MS Homo sapiens
73 GOLGA6L5P  
Two-hybrid Homo sapiens
74 SKAP1 8631
Affinity Capture-MS Homo sapiens
75 PEG10 23089
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
76 ADA 100
Co-fractionation Homo sapiens
77 RPL5 6125
Affinity Capture-MS Homo sapiens
78 BAG6 7917
Two-hybrid Homo sapiens
79 PURG  
Affinity Capture-MS Homo sapiens
80 DAZ2  
Affinity Capture-MS Homo sapiens
81 SH3GL2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
82 PABPC1 26986
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
83 MKRN2 23609
Affinity Capture-MS Homo sapiens
84 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
85 DDX5 1655
Co-fractionation Homo sapiens
86 NTRK1 4914
Affinity Capture-MS Homo sapiens
87 DCAF7 10238
Affinity Capture-MS Homo sapiens
88 DCP1A 55802
Affinity Capture-MS Homo sapiens
89 SYNCRIP 10492
Co-fractionation Homo sapiens
90 RCCD1  
Affinity Capture-MS Homo sapiens
91 CELA2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 NCL 4691
Co-fractionation Homo sapiens
93 NIPSNAP1 8508
Affinity Capture-MS Homo sapiens
94 HMGB2 3148
Affinity Capture-MS Homo sapiens
95 NCOA4 8031
Two-hybrid Homo sapiens
96 KDF1  
Affinity Capture-MS Homo sapiens
97 YEATS4  
Affinity Capture-MS Homo sapiens
98 ATXN1 6310
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
99 EIF3G 8666
Affinity Capture-MS Homo sapiens
100 AIM1L  
Affinity Capture-MS Homo sapiens
101 RC3H2  
Affinity Capture-MS Homo sapiens
102 RBM47 54502
Affinity Capture-MS Homo sapiens
103 PTPRA 5786
Affinity Capture-MS Homo sapiens
104 CALR 811
Co-fractionation Homo sapiens
105 CUL3 8452
Affinity Capture-MS Homo sapiens
106 EGFR 1956
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
107 HSPA8 3312
Co-fractionation Homo sapiens
108 RBFOX1 54715
Two-hybrid Homo sapiens
109 HNRNPA1 3178
Co-fractionation Homo sapiens
110 EPRS 2058
Co-fractionation Homo sapiens
111 MYC  
Affinity Capture-MS Homo sapiens
112 CELF5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 NXF1 10482
Affinity Capture-RNA Homo sapiens
114 NXF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 F12  
Affinity Capture-MS Homo sapiens
116 KIF1BP 26128
Two-hybrid Homo sapiens
117 PSPC1 55269
Affinity Capture-MS Homo sapiens
118 RPA3 6119
Proximity Label-MS Homo sapiens
119 SEC16A 9919
Affinity Capture-MS Homo sapiens
120 PABPC5 140886
Affinity Capture-MS Homo sapiens
121 CLASRP  
Affinity Capture-MS Homo sapiens
122 HSPA1A 3303
Co-fractionation Homo sapiens
123 ACTN4 81
Co-fractionation Homo sapiens
124 ACTN2 88
Two-hybrid Homo sapiens
125 BMI1  
Affinity Capture-MS Homo sapiens
126 KHDRBS2  
Co-fractionation Homo sapiens
127 FAM195A  
Affinity Capture-MS Homo sapiens
128 AKAP1 8165
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 RBMS2 5939
Affinity Capture-MS Homo sapiens
130 RPS16 6217
Affinity Capture-MS Homo sapiens
131 FGL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 DHX15 1665
Co-fractionation Homo sapiens
133 RNF43  
Proximity Label-MS Homo sapiens
134 ASB3 51130
Affinity Capture-MS Homo sapiens
135 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
136 IDH3B 3420
Two-hybrid Homo sapiens
137 RPL4 6124
Affinity Capture-MS Homo sapiens
138 WWOX 51741
Affinity Capture-MS Homo sapiens
139 MNDA 4332
Affinity Capture-MS Homo sapiens
140 NUFIP2 57532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 LSM14A 26065
Affinity Capture-MS Homo sapiens
142 HNRNPA2B1 3181
Co-fractionation Homo sapiens
143 NME2P1 283458
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
144 WRAP53  
Affinity Capture-MS Homo sapiens
145 MKRN3  
Affinity Capture-MS Homo sapiens
146 SHFM1 7979
Affinity Capture-MS Homo sapiens
147 SRP72 6731
Affinity Capture-MS Homo sapiens
148 ELAVL2 1993
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
149 TDRD7 23424
Two-hybrid Homo sapiens
150 NUP35 129401
Proximity Label-MS Homo sapiens
151 APOBEC3D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 RBFOX2 23543
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
153 CEBPA  
Protein-peptide Homo sapiens
154 MOV10 4343
Affinity Capture-RNA Homo sapiens
155 HNRNPL 3191
Co-fractionation Homo sapiens
156 CAPRIN1 4076
Affinity Capture-MS Homo sapiens
157 RTCB 51493
Affinity Capture-MS Homo sapiens
158 UPF1 5976
Affinity Capture-MS Homo sapiens
159 WDR90  
Affinity Capture-MS Homo sapiens
160 SHARPIN  
Affinity Capture-MS Homo sapiens
161 SERBP1 26135
Proximity Label-MS Homo sapiens
162 ZNRD1  
Two-hybrid Homo sapiens
163 PRKAG3  
Affinity Capture-MS Homo sapiens
164 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
165 SRP9 6726
Affinity Capture-MS Homo sapiens
166 RC3H1 149041
Affinity Capture-MS Homo sapiens
167 PTPN18 26469
Affinity Capture-MS Homo sapiens
168 PRMT1 3276
Affinity Capture-MS Homo sapiens
169 GAPDH 2597
Co-fractionation Homo sapiens
170 BCAT1 586
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
171 GPKOW  
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which ATXN2 is involved
No pathways found





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