Gene description for ATXN2
Gene name ataxin 2
Gene symbol ATXN2
Other names/aliases ASL13
ATX2
SCA2
TNRC13
Species Homo sapiens
 Database cross references - ATXN2
ExoCarta ExoCarta_6311
Vesiclepedia VP_6311
Entrez Gene 6311
HGNC 10555
MIM 601517
UniProt Q99700  
 ATXN2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ATXN2
Molecular Function
    RNA binding GO:0003723 NAS
    epidermal growth factor receptor binding GO:0005154 IPI
    protein binding GO:0005515 IPI
    protein C-terminus binding GO:0008022 IPI
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    regulation of cytoplasmic mRNA processing body assembly GO:0010603 IBA
    cytoplasmic mRNA processing body assembly GO:0033962 IMP
    neuron projection morphogenesis GO:0048812 IEA
    regulation of translation GO:0006417 NAS
    negative regulation of multicellular organism growth GO:0040015 IEA
    negative regulation of receptor internalization GO:0002091 IMP
    stress granule assembly GO:0034063 IMP
    RNA metabolic process GO:0016070 NAS
    homeostasis of number of cells GO:0048872 IEA
    neuromuscular process GO:0050905 IEA
    RNA transport GO:0050658 NAS
    cerebellar Purkinje cell differentiation GO:0021702 IEA
Subcellular Localization
    polysome GO:0005844 IDA
    membrane GO:0016020 IDA
    Golgi apparatus GO:0005794 IDA
    cytoplasmic stress granule GO:0010494 IDA
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
    ribonucleoprotein complex GO:0030529 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    trans-Golgi network GO:0005802 IDA
 Experiment description of studies that identified ATXN2 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ATXN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD247 919
Affinity Capture-Western Homo sapiens
2 CHGB 1114
Two-hybrid Homo sapiens
3 VHL  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ATXN2 is involved
No pathways found





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