Gene description for KHDRBS1
Gene name KH domain containing, RNA binding, signal transduction associated 1
Gene symbol KHDRBS1
Other names/aliases Sam68
p62
p68
Species Homo sapiens
 Database cross references - KHDRBS1
ExoCarta ExoCarta_10657
Entrez Gene 10657
HGNC 18116
MIM 602489
UniProt Q07666  
 KHDRBS1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for KHDRBS1
Molecular Function
    SH3 domain binding GO:0017124 IEA
    poly(U) RNA binding GO:0008266 IDA
    protein binding GO:0005515 IPI
    poly(A) binding GO:0008143 IDA
    poly(A) RNA binding GO:0044822 IDA
    protein complex binding GO:0032403 IEA
    SH3/SH2 adaptor activity GO:0005070 IPI
    RNA binding GO:0003723 IDA
    DNA binding GO:0003677 TAS
    identical protein binding GO:0042802 IPI
Biological Process
    cell cycle arrest GO:0007050 TAS
    transcription, DNA-templated GO:0006351 IEA
    positive regulation of translational initiation GO:0045948 IDA
    positive regulation of signal transduction GO:0009967 IEA
    regulation of protein stability GO:0031647 IDA
    negative regulation of transcription, DNA-templated GO:0045892 ISS
    signal transduction GO:0007165 TAS
    cell proliferation GO:0008283 TAS
    G2/M transition of mitotic cell cycle GO:0000086 ISS
    regulation of RNA export from nucleus GO:0046831 ISS
    cell surface receptor signaling pathway GO:0007166 IDA
    mRNA processing GO:0006397 TAS
    positive regulation of RNA export from nucleus GO:0046833 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    membrane GO:0016020 IDA
    nucleus GO:0005634 IDA
    Grb2-Sos complex GO:0070618 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified KHDRBS1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KHDRBS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RAPSN  
Two-hybrid Homo sapiens
2 RASA1 5921
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
3 GRAP2 9402
Reconstituted Complex Homo sapiens
4 STUB1  
Two-hybrid Homo sapiens
5 FNBP4  
Invitro Homo sapiens
6 KHDRBS3  
Two-hybrid Homo sapiens
7 NCK1 4690
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
8 GRB2 2885
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
9 YT521  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
10 CRK 1398
Reconstituted Complex Homo sapiens
11 TNFSF11  
Biochemical Activity Homo sapiens
12 WBP4  
Invitro Homo sapiens
13 LCK 3932
Invivo Homo sapiens
14 TUBB3 10381
Two-hybrid Homo sapiens
15 INSR 3643
Affinity Capture-Western Homo sapiens
16 IRS1 3667
Affinity Capture-Western Homo sapiens
17 CREBBP  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
18 NCF1  
Reconstituted Complex Homo sapiens
19 HNRNPK 3190
Invivo Homo sapiens
Invitro Homo sapiens
20 PTK6  
Invivo Homo sapiens
Invitro Homo sapiens
21 FYN 2534
Invivo Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
22 Grap2  
Reconstituted Complex Mus musculus
23 SRC 6714
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
24 STAT3 6774
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
25 PIK3R1 5295
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
26 KHDRBS1 10657
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
27 BTK 695
Affinity Capture-Western Homo sapiens
28 EMG1 10436
Two-hybrid Homo sapiens
29 PLCG1 5335
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
30 PRMT1 3276
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
31 ITK 3702
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
32 DHX9 1660
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which KHDRBS1 is involved
No pathways found





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