Gene description for AZIN1
Gene name antizyme inhibitor 1
Gene symbol AZIN1
Other names/aliases AZI
AZIA1
OAZI
OAZIN
ODC1L
Species Homo sapiens
 Database cross references - AZIN1
ExoCarta ExoCarta_51582
Vesiclepedia VP_51582
Entrez Gene 51582
HGNC 16432
MIM 607909
UniProt O14977  
 AZIN1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for AZIN1
Molecular Function
    protein binding GO:0005515 IPI
    ornithine decarboxylase activity GO:0004586 IBA
    ornithine decarboxylase activator activity GO:0042978 IDA
Biological Process
    cellular nitrogen compound metabolic process GO:0034641 TAS
    negative regulation of protein catabolic process GO:0042177 IDA
    regulation of cellular amino acid metabolic process GO:0006521 TAS
    positive regulation of polyamine transmembrane transport GO:1902269 IDA
    positive regulation of catalytic activity GO:0043085 IDA
    putrescine biosynthetic process from ornithine GO:0033387 IBA
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    nucleus GO:0005634 ISS
    cytosol GO:0005829 TAS
 Experiment description of studies that identified AZIN1 in exosomes
1
Experiment ID 237
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Enriched markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for AZIN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FANCC 2176
Two-hybrid Homo sapiens
2 FANCA  
Two-hybrid Homo sapiens
3 OAZ2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which AZIN1 is involved
PathwayEvidenceSource
Regulation of ornithine decarboxylase (ODC) TAS Reactome





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