Gene description for AZIN1
Gene name antizyme inhibitor 1
Gene symbol AZIN1
Other names/aliases AZI
AZIA1
OAZI
OAZIN
ODC1L
Species Homo sapiens
 Database cross references - AZIN1
ExoCarta ExoCarta_51582
Vesiclepedia VP_51582
Entrez Gene 51582
HGNC 16432
MIM 607909
UniProt O14977  
 AZIN1 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for AZIN1
Molecular Function
    ornithine decarboxylase activity GO:0004586 IBA
    protein binding GO:0005515 IPI
    ornithine decarboxylase activator activity GO:0042978 IBA
    ornithine decarboxylase activator activity GO:0042978 IDA
Biological Process
    putrescine biosynthetic process from ornithine GO:0033387 IBA
    negative regulation of protein catabolic process GO:0042177 IBA
    negative regulation of protein catabolic process GO:0042177 IDA
    positive regulation of polyamine transmembrane transport GO:1902269 IBA
    positive regulation of polyamine transmembrane transport GO:1902269 IDA
Subcellular Localization
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified AZIN1 in sEVs
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for AZIN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARNTL  
Two-hybrid Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 ABCC2 1244
Two-hybrid Homo sapiens
4 MSRB3 253827
Affinity Capture-MS Homo sapiens
5 KRAS 3845
Negative Genetic Homo sapiens
6 OAZ1 4946
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 TDP2 51567
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 FANCA  
Two-hybrid Homo sapiens
9 OAZ3  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
10 C12orf49  
Positive Genetic Homo sapiens
11 KLC2 64837
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 KLC1 3831
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 SREBF2 6721
Negative Genetic Homo sapiens
14 KHDRBS1 10657
Two-hybrid Homo sapiens
15 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
16 OAZ2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 FANCC 2176
Two-hybrid Homo sapiens
18 KIF5C 3800
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 ADSSL1  
Two-hybrid Homo sapiens
20 KIF5B 3799
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 KLC4 89953
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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