Gene description for TDP2
Gene name tyrosyl-DNA phosphodiesterase 2
Gene symbol TDP2
Other names/aliases AD022
EAP2
EAPII
TTRAP
dJ30M3.3
hTDP2
Species Homo sapiens
 Database cross references - TDP2
ExoCarta ExoCarta_51567
Entrez Gene 51567
HGNC 17768
MIM 605764
UniProt O95551  
 TDP2 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for TDP2
Molecular Function
    nuclease activity GO:0004518 IEA
    transcription corepressor activity GO:0003714 TAS
    5'-tyrosyl-DNA phosphodiesterase activity GO:0070260 IMP
    tyrosyl-RNA phosphodiesterase activity GO:0036317 IDA
    protein binding GO:0005515 IPI
    magnesium ion binding GO:0000287 TAS
    single-stranded DNA binding GO:0003697 IDA
    manganese ion binding GO:0030145 IDA
Biological Process
    double-strand break repair GO:0006302 IMP
    negative regulation of nucleic acid-templated transcription GO:1903507 TAS
    cell surface receptor signaling pathway GO:0007166 TAS
    nucleic acid phosphodiester bond hydrolysis GO:0090305 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleolus GO:0005730 IEA
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
    intercellular bridge GO:0045171 IDA
    PML body GO:0016605 IDA
 Experiment description of studies that identified TDP2 in exosomes
1
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TDP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TNFRSF1B  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
2 CD40 958
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 UBE2I 7329
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
4 TRAF6 7189
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
5 TNFRSF8 943
Affinity Capture-Western Homo sapiens
6 TRAF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
7 TRAF5  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
8 SUMO1 7341
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
9 TRAF3 7187
Affinity Capture-Western Homo sapiens
10 ETS1  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which TDP2 is involved
No pathways found





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