Gene description for ATXN1
Gene name ataxin 1
Gene symbol ATXN1
Other names/aliases ATX1
D6S504E
SCA1
Species Homo sapiens
 Database cross references - ATXN1
ExoCarta ExoCarta_6310
Entrez Gene 6310
HGNC 10548
MIM 601556
UniProt P54253  
 ATXN1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for ATXN1
Molecular Function
    chromatin binding GO:0003682 IEA
    identical protein binding GO:0042802 IPI
    DNA binding GO:0003677 IEA
    poly(U) RNA binding GO:0008266 IDA
    poly(G) binding GO:0034046 IDA
    protein self-association GO:0043621 IDA
    protein C-terminus binding GO:0008022 IPI
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of phosphorylation GO:0042326 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    transcription, DNA-templated GO:0006351 IEA
    adult locomotory behavior GO:0008344 IEA
    nuclear export GO:0051168 IDA
    negative regulation of insulin-like growth factor receptor signaling pathway GO:0043569 IEA
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    lung alveolus development GO:0048286 IEA
    RNA processing GO:0006396 NAS
    regulation of excitatory postsynaptic membrane potential GO:0060079 IEA
    visual learning GO:0008542 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
    nuclear RNA export factor complex GO:0042272 IDA
    nuclear matrix GO:0016363 IDA
    nucleus GO:0005634 IDA
    nuclear inclusion body GO:0042405 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified ATXN1 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for ATXN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBQLN4 56893
Two-hybrid Homo sapiens
2 PQBP1  
Invitro Homo sapiens
Invivo Homo sapiens
3 USP7 7874
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
4 GAPDH 2597
Invitro Homo sapiens
Two-hybrid Homo sapiens
5 COIL  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
6 ANP32A 8125
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 ZHX1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ATXN1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here