Gene description for SUMO3
Gene name small ubiquitin-like modifier 3
Gene symbol SUMO3
Other names/aliases SMT3A
SMT3H1
SUMO-3
Smt3B
Species Homo sapiens
 Database cross references - SUMO3
ExoCarta ExoCarta_6612
Vesiclepedia VP_6612
Entrez Gene 6612
HGNC 11124
MIM 602231
UniProt P55854  
 SUMO3 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
 Gene ontology annotations for SUMO3
Molecular Function
    SUMO transferase activity GO:0019789 IEA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000060 IEA
    post-translational protein modification GO:0043687 TAS
    protein sumoylation GO:0016925 TAS
    cellular protein metabolic process GO:0044267 TAS
    protein localization to nucleus GO:0034504 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    PML body GO:0016605 IEA
    nucleoplasm GO:0005654 TAS
    extracellular exosome GO:0070062 IDA
    kinetochore GO:0000776 TAS
    nucleus GO:0005634 IDA
 Experiment description of studies that identified SUMO3 in exosomes
1
Experiment ID 275
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
EV Enriched markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
2
Experiment ID 274
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
EV Enriched markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for SUMO3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SENP2 59343
Invivo Homo sapiens
Invitro Homo sapiens
2 UBE2I 7329
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 STAB2 55576
Biochemical Activity Homo sapiens
4 UBA2 10054
Affinity Capture-MS Homo sapiens
5 VIM 7431
Two-hybrid Homo sapiens
6 SAE1 10055
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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