Gene description for HIPK2
Gene name	homeodomain interacting protein kinase 2
Gene symbol	HIPK2
Other names/aliases	PRO0593
Species	Homo sapiens
Database cross references - HIPK2
ExoCarta	ExoCarta_28996
Entrez Gene	28996
HGNC	14402
MIM	606868
UniProt	Q9H2X6
HIPK2 identified in exosomes derived from the following tissue/cell type
Endothelial cells	26027894

Gene ontology annotations for HIPK2

Molecular Function     protein binding GO:0005515 IPI     RNA polymerase II transcription coactivator activity GO:0001105 ISS     protein serine/threonine kinase activity GO:0004674 ISS     RNA polymerase II activating transcription factor binding GO:0001102 ISS     virion binding GO:0046790 IPI     transcription corepressor activity GO:0003714 IDA     ATP binding GO:0005524 IEA     protein kinase activity GO:0004672 IDA     SMAD binding GO:0046332 IPI Biological Process     intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 TAS     positive regulation of protein binding GO:0032092 ISS     smoothened signaling pathway GO:0007224 IEA     cellular response to hypoxia GO:0071456 TAS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS     positive regulation of angiogenesis GO:0045766 IDA     positive regulation of DNA binding GO:0043388 IEA     eye development GO:0001654 ISS     positive regulation of cell proliferation GO:0008284 IEA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA     positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 IMP     transforming growth factor beta receptor signaling pathway GO:0007179 IEA     adult walking behavior GO:0007628 IEA     iris morphogenesis GO:0061072 IEA     positive regulation of transcription, DNA-templated GO:0045893 IMP     DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 IDA     positive regulation of JNK cascade GO:0046330 IMP     neuron differentiation GO:0030182 IEA     anterior/posterior pattern specification GO:0009952 IEA     negative regulation of BMP signaling pathway GO:0030514 IMP     erythrocyte differentiation GO:0030218 ISS     peptidyl-threonine phosphorylation GO:0018107 ISS     embryonic retina morphogenesis in camera-type eye GO:0060059 IEA     modulation by virus of host morphology or physiology GO:0019048 NAS     peptidyl-serine phosphorylation GO:0018105 ISS     regulation of cell cycle GO:0051726 TAS     transcription, DNA-templated GO:0006351 IEA     voluntary musculoskeletal movement GO:0050882 IEA     protein phosphorylation GO:0006468 IDA     SMAD protein signal transduction GO:0060395 IDA     embryonic camera-type eye morphogenesis GO:0048596 IEA     positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 ISS     lens induction in camera-type eye GO:0060235 IEA     negative regulation of neuron apoptotic process GO:0043524 IEA     retina layer formation GO:0010842 IEA     PML body organization GO:0030578 TAS     intrinsic apoptotic signaling pathway GO:0097193 NAS Subcellular Localization     nucleus GO:0005634 IDA     PML body GO:0016605 IDA     nuclear body GO:0016604 TAS     RNA polymerase II transcription factor complex GO:0090575 ISS     cytoplasm GO:0005737 ISS