Gene description for MYBL2
Gene name v-myb avian myeloblastosis viral oncogene homolog-like 2
Gene symbol MYBL2
Other names/aliases B-MYB
BMYB
Species Homo sapiens
 Database cross references - MYBL2
ExoCarta ExoCarta_4605
Vesiclepedia VP_4605
Entrez Gene 4605
HGNC 7548
MIM 601415
UniProt P10244  
 MYBL2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for MYBL2
Molecular Function
    sequence-specific DNA binding transcription factor activity GO:0003700 TAS
    protein binding GO:0005515 IPI
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA
    chromatin binding GO:0003682 IEA
Biological Process
    G2/M transition of mitotic cell cycle GO:0000086 TAS
    mitotic cell cycle GO:0000278 TAS
    mitotic spindle assembly GO:0090307 IEA
    transcription, DNA-templated GO:0006351 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    regulation of cell cycle GO:0051726 TAS
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    Myb complex GO:0031523 IEA
 Experiment description of studies that identified MYBL2 in exosomes
1
Experiment ID 236
MISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Enriched markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for MYBL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCND1 595
Invitro Homo sapiens
Invivo Homo sapiens
2 MYBL2 4605
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
3 ZNF622 90441
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
4 CCNA1  
Invitro Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
5 CDC34 997
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
6 E2F3  
Two-hybrid Homo sapiens
7 UBB 7314
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
8 E2F1 1869
Two-hybrid Homo sapiens
9 RBL1  
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
10 SKP2  
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
11 CCNA2 890
Invivo Homo sapiens
12 PARP1 142
Invivo Homo sapiens
13 SND1 27044
Affinity Capture-MS Homo sapiens
14 CREBBP  
Affinity Capture-Western Homo sapiens
Phenotypic Enhancement Homo sapiens
15 CDK9 1025
Invitro Homo sapiens
Invivo Homo sapiens
16 CDKN1C  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
17 EP300 2033
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
18 NCOR2  
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which MYBL2 is involved
PathwayEvidenceSource
G0 and Early G1 TAS Reactome
Polo-like kinase mediated events TAS Reactome





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