Gene description for DPY30
Gene name dpy-30 homolog (C. elegans)
Gene symbol DPY30
Other names/aliases Cps25
HDPY-30
Saf19
Species Homo sapiens
 Database cross references - DPY30
ExoCarta ExoCarta_84661
Entrez Gene 84661
HGNC 24590
MIM 612032
UniProt Q9C005  
 DPY30 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
Squamous carcinoma cells 20124223    
 Gene ontology annotations for DPY30
Molecular Function
    identical protein binding GO:0042802 IPI
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IPI
Biological Process
    chromatin organization GO:0006325 TAS
    regulation of transcription, DNA-templated GO:0006355 IEA
    histone H3-K4 methylation GO:0051568 IDA
    endosomal transport GO:0016197 IMP
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    Golgi apparatus GO:0005794 IDA
    nucleus GO:0005634 IDA
    trans-Golgi network GO:0005802 IDA
    histone methyltransferase complex GO:0035097 IDA
    nucleoplasm GO:0005654 TAS
    Set1C/COMPASS complex GO:0048188 IDA
 Experiment description of studies that identified DPY30 in exosomes
1
Experiment ID 275
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
2
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DPY30
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ASH2L  
Two-hybrid Homo sapiens
2 DPY30 84661
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 PRPF3  
Two-hybrid Homo sapiens
4 N/A  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which DPY30 is involved
PathwayEvidenceSource
PKMTs methylate histone lysines TAS Reactome





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