Gene description for PSIP1
Gene name PC4 and SFRS1 interacting protein 1
Gene symbol PSIP1
Other names/aliases DFS70
LEDGF
PAIP
PSIP2
p52
p75
Species Homo sapiens
 Database cross references - PSIP1
ExoCarta ExoCarta_11168
Entrez Gene 11168
HGNC 9527
MIM 603620
UniProt O75475  
 PSIP1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PSIP1
Molecular Function
    RNA polymerase II transcription coactivator activity GO:0001105 IDA
    supercoiled DNA binding GO:0097100 ISS
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
    activating transcription factor binding GO:0033613 IDA
    chromatin binding GO:0003682 IDA
Biological Process
    transcription, DNA-templated GO:0006351 IEA
    response to oxidative stress GO:0006979 ISS
    response to heat GO:0009408 ISS
    mRNA 5'-splice site recognition GO:0000395 IDA
    viral process GO:0016032 TAS
    establishment of integrated proviral latency GO:0075713 TAS
    regulation of transcription, DNA-templated GO:0006355 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    nuclear heterochromatin GO:0005720 IDA
    nucleolus GO:0005730 IDA
    transcriptionally active chromatin GO:0035327 ISS
    cytosol GO:0005829 TAS
    nucleus GO:0005634 IDA
    nuclear periphery GO:0034399 IDA
 Experiment description of studies that identified PSIP1 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PSIP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SRSF1 6426
Invivo Homo sapiens
Invitro Homo sapiens
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