Gene description for SLC7A6
Gene name solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
Gene symbol SLC7A6
Other names/aliases LAT-2
LAT3
y+LAT-2
Species Homo sapiens
 Database cross references - SLC7A6
ExoCarta ExoCarta_9057
Vesiclepedia VP_9057
Entrez Gene 9057
HGNC 11064
MIM 605641
UniProt Q92536  
 SLC7A6 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
 Gene ontology annotations for SLC7A6
Molecular Function
    protein binding GO:0005515 IPI
    amino acid transmembrane transporter activity GO:0015171 TAS
    basic amino acid transmembrane transporter activity GO:0015174 IMP
    L-amino acid transmembrane transporter activity GO:0015179 IBA
    arginine binding GO:0034618 IDA
    L-arginine transmembrane transporter activity GO:0061459 IDA
    L-lysine:L-arginine antiporter activity GO:0106439 IDA
Biological Process
    amino acid transmembrane transport GO:0003333 IBA
    amino acid transmembrane transport GO:0003333 TAS
    nitric oxide biosynthetic process GO:0006809 ISS
    neutral amino acid transport GO:0015804 IDA
    L-leucine transport GO:0015820 IDA
    ornithine transport GO:0015822 IMP
    glycine betaine transport GO:0031460 ISS
    L-lysine transmembrane transport GO:1903401 IEA
    L-arginine transmembrane transport GO:1903826 IDA
    L-arginine transmembrane transport GO:1903826 IMP
Subcellular Localization
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified SLC7A6 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SLC7A6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 DDX46 9879
Affinity Capture-MS Homo sapiens
3 CDC14A  
Affinity Capture-MS Homo sapiens
4 C5AR1  
Affinity Capture-MS Homo sapiens
5 CNN3 1266
Affinity Capture-MS Homo sapiens
6 VIPR2  
Affinity Capture-MS Homo sapiens
7 UHRF1BP1 54887
Affinity Capture-MS Homo sapiens
8 PARP1 142
Affinity Capture-MS Homo sapiens
9 HDGF 3068
Affinity Capture-MS Homo sapiens
10 MAS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 TCERG1 10915
Affinity Capture-MS Homo sapiens
12 RNF169  
Affinity Capture-MS Homo sapiens
13 CALM2 805
Affinity Capture-MS Homo sapiens
14 TMEM184A  
Affinity Capture-MS Homo sapiens
15 DOLK 22845
Two-hybrid Homo sapiens
16 RYK 6259
Affinity Capture-MS Homo sapiens
17 P2RY2 5029
Affinity Capture-MS Homo sapiens
18 TSPAN15 23555
Affinity Capture-MS Homo sapiens
19 LZTS1  
Affinity Capture-MS Homo sapiens
20 ARF6 382
Proximity Label-MS Homo sapiens
21 ANAPC11  
Affinity Capture-MS Homo sapiens
22 DDX58 23586
Affinity Capture-RNA Homo sapiens
23 ZNF592 9640
Affinity Capture-MS Homo sapiens
24 ILVBL 10994
Affinity Capture-MS Homo sapiens
25 EXOC4 60412
Affinity Capture-MS Homo sapiens
26 PSIP1 11168
Affinity Capture-MS Homo sapiens
27 SLC18A2  
Affinity Capture-MS Homo sapiens
28 SLC15A1  
Affinity Capture-MS Homo sapiens
29 RAB2A 5862
Proximity Label-MS Homo sapiens
30 NEFM 4741
Affinity Capture-MS Homo sapiens
31 SLC3A2 6520
Affinity Capture-MS Homo sapiens
32 GPR45  
Affinity Capture-MS Homo sapiens
33 CIAPIN1 57019
Affinity Capture-MS Homo sapiens
34 POMK  
Affinity Capture-MS Homo sapiens
35 GPR182  
Affinity Capture-MS Homo sapiens
36 CEP78 84131
Affinity Capture-MS Homo sapiens
37 KRAS 3845
Proximity Label-MS Homo sapiens
38 VIPR1  
Affinity Capture-MS Homo sapiens
39 PIK3C2A 5286
Affinity Capture-MS Homo sapiens
40 SLC22A4 6583
Affinity Capture-MS Homo sapiens
41 TSC22D3  
Affinity Capture-MS Homo sapiens
42 SCN3B  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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