Gene description for SLC22A4
Gene name solute carrier family 22 (organic cation/zwitterion transporter), member 4
Gene symbol SLC22A4
Other names/aliases OCTN1
Species Homo sapiens
 Database cross references - SLC22A4
ExoCarta ExoCarta_6583
Vesiclepedia VP_6583
Entrez Gene 6583
HGNC 10968
MIM 604190
UniProt Q9H015  
 SLC22A4 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SLC22A4
Molecular Function
    acetylcholine transmembrane transporter activity GO:0005277 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    secondary active organic cation transmembrane transporter activity GO:0008513 TAS
    amino acid transmembrane transporter activity GO:0015171 IDA
    amino-acid betaine transmembrane transporter activity GO:0015199 IDA
    carnitine transmembrane transporter activity GO:0015226 IDA
    symporter activity GO:0015293 IEA
    quaternary ammonium group transmembrane transporter activity GO:0015651 IBA
    quaternary ammonium group transmembrane transporter activity GO:0015651 IDA
    PDZ domain binding GO:0030165 IPI
Biological Process
    triglyceride metabolic process GO:0006641 IEA
    sodium ion transport GO:0006814 IEA
    neurotransmitter transport GO:0006836 IEA
    carnitine metabolic process GO:0009437 IEA
    quaternary ammonium group transport GO:0015697 IBA
    quaternary ammonium group transport GO:0015697 IDA
    carnitine transport GO:0015879 IDA
    xenobiotic transport GO:0042908 IDA
    amino acid import across plasma membrane GO:0089718 IDA
    acetate ester transport GO:1901374 IEA
    carnitine transmembrane transport GO:1902603 IEA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    plasma membrane GO:0005886 IC
    plasma membrane GO:0005886 TAS
    basal plasma membrane GO:0009925 IDA
    apical plasma membrane GO:0016324 IDA
    mitochondrial membrane GO:0031966 IDA
 Experiment description of studies that identified SLC22A4 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SLC22A4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KDELR3 11015
Affinity Capture-MS Homo sapiens
2 MTFP1  
Affinity Capture-MS Homo sapiens
3 AGPAT5 55326
Affinity Capture-MS Homo sapiens
4 C6orf62 81688
Affinity Capture-MS Homo sapiens
5 DERL2 51009
Affinity Capture-MS Homo sapiens
6 DHRS7 51635
Affinity Capture-MS Homo sapiens
7 TFB2M  
Affinity Capture-MS Homo sapiens
8 ORMDL3 94103
Affinity Capture-MS Homo sapiens
9 CCDC132 55610
Affinity Capture-MS Homo sapiens
10 ABHD14B 84836
Affinity Capture-MS Homo sapiens
11 EFR3A 23167
Affinity Capture-MS Homo sapiens
12 LMBRD2 92255
Affinity Capture-MS Homo sapiens
13 PI4K2A 55361
Affinity Capture-MS Homo sapiens
14 VMP1 81671
Affinity Capture-MS Homo sapiens
15 STK39 27347
Affinity Capture-MS Homo sapiens
16 MFSD5  
Affinity Capture-MS Homo sapiens
17 TMEM161B  
Affinity Capture-MS Homo sapiens
18 MFSD8 256471
Affinity Capture-MS Homo sapiens
19 PNMAL1  
Affinity Capture-MS Homo sapiens
20 COG2 22796
Affinity Capture-MS Homo sapiens
21 IMMP1L  
Affinity Capture-MS Homo sapiens
22 SMAP2 64744
Affinity Capture-MS Homo sapiens
23 RTN4 57142
Affinity Capture-MS Homo sapiens
24 CPT1A 1374
Affinity Capture-MS Homo sapiens
25 SPG7  
Affinity Capture-MS Homo sapiens
26 SLC5A6 8884
Affinity Capture-MS Homo sapiens
27 PTRH2 51651
Affinity Capture-MS Homo sapiens
28 PTDSS2 81490
Affinity Capture-MS Homo sapiens
29 ALG10  
Affinity Capture-MS Homo sapiens
30 SERPINE2 5270
Affinity Capture-MS Homo sapiens
31 NDUFB8 4714
Affinity Capture-MS Homo sapiens
32 ELOVL2  
Affinity Capture-MS Homo sapiens
33 PTPMT1 114971
Affinity Capture-MS Homo sapiens
34 CYB5R1 51706
Affinity Capture-MS Homo sapiens
35 ABHD3  
Affinity Capture-MS Homo sapiens
36 PACS1 55690
Affinity Capture-MS Homo sapiens
37 B4GALT7 11285
Affinity Capture-MS Homo sapiens
38 STX7 8417
Affinity Capture-MS Homo sapiens
39 YIPF3 25844
Affinity Capture-MS Homo sapiens
40 TMEM115 11070
Affinity Capture-MS Homo sapiens
41 SURF1  
Affinity Capture-MS Homo sapiens
42 ZDHHC21  
Affinity Capture-MS Homo sapiens
43 CES2 8824
Affinity Capture-MS Homo sapiens
44 C20orf24  
Affinity Capture-MS Homo sapiens
45 SLC30A5 64924
Affinity Capture-MS Homo sapiens
46 SLC25A46 91137
Affinity Capture-MS Homo sapiens
47 PARL  
Affinity Capture-MS Homo sapiens
48 SNTG1  
Affinity Capture-MS Homo sapiens
49 GPRC5C 55890
Affinity Capture-MS Homo sapiens
50 ATP13A3 79572
Affinity Capture-MS Homo sapiens
51 UQCRQ 27089
Affinity Capture-MS Homo sapiens
52 AGPAT4 56895
Affinity Capture-MS Homo sapiens
53 BDH1 622
Affinity Capture-MS Homo sapiens
54 TMEM87A 25963
Affinity Capture-MS Homo sapiens
55 DGAT1 8694
Affinity Capture-MS Homo sapiens
56 SERPINF2 5345
Affinity Capture-MS Homo sapiens
57 DIRC2 84925
Affinity Capture-MS Homo sapiens
58 SLC43A1 8501
Affinity Capture-MS Homo sapiens
59 TAZ  
Affinity Capture-MS Homo sapiens
60 TMEM120A 83862
Affinity Capture-MS Homo sapiens
61 ATP8B2 57198
Affinity Capture-MS Homo sapiens
62 TMEM177  
Affinity Capture-MS Homo sapiens
63 ADGRL3 23284
Affinity Capture-MS Homo sapiens
64 KLHDC2  
Affinity Capture-MS Homo sapiens
65 SFXN3 81855
Affinity Capture-MS Homo sapiens
66 OCLN 100506658
Affinity Capture-MS Homo sapiens
67 FADS1 3992
Affinity Capture-MS Homo sapiens
68 SLC25A6 293
Affinity Capture-MS Homo sapiens
69 TAMM41  
Affinity Capture-MS Homo sapiens
70 ND1  
Affinity Capture-MS Homo sapiens
71 MRS2  
Affinity Capture-MS Homo sapiens
72 LRRC8E 80131
Affinity Capture-MS Homo sapiens
73 SLC7A2 6542
Affinity Capture-MS Homo sapiens
74 SLC7A6 9057
Affinity Capture-MS Homo sapiens
75 SLC25A17 10478
Affinity Capture-MS Homo sapiens
76 TMEM56  
Affinity Capture-MS Homo sapiens
77 FAM127A  
Affinity Capture-MS Homo sapiens
78 COA1  
Affinity Capture-MS Homo sapiens
79 ORMDL1 94101
Affinity Capture-MS Homo sapiens
80 ARL10  
Affinity Capture-MS Homo sapiens
81 SFXN5  
Affinity Capture-MS Homo sapiens
82 SLC33A1 9197
Affinity Capture-MS Homo sapiens
83 GOLT1B 51026
Affinity Capture-MS Homo sapiens
84 MFSD12  
Affinity Capture-MS Homo sapiens
85 SPPL3  
Affinity Capture-MS Homo sapiens
86 CSNK1G3 1456
Affinity Capture-MS Homo sapiens
87 SLC25A24 29957
Affinity Capture-MS Homo sapiens
88 DMXL2  
Affinity Capture-MS Homo sapiens
89 SELT 51714
Affinity Capture-MS Homo sapiens
90 HSD17B7 51478
Affinity Capture-MS Homo sapiens
91 NT5C1A  
Affinity Capture-MS Homo sapiens
92 ND5 4540
Affinity Capture-MS Homo sapiens
93 TVP23C  
Affinity Capture-MS Homo sapiens
94 PIGW  
Affinity Capture-MS Homo sapiens
95 SLC35F2 54733
Affinity Capture-MS Homo sapiens
96 SLC30A6 55676
Affinity Capture-MS Homo sapiens
97 SLC25A35  
Affinity Capture-MS Homo sapiens
98 CRELD1 78987
Affinity Capture-MS Homo sapiens
99 SLC22A5 6584
Affinity Capture-MS Homo sapiens
100 SLC26A2 1836
Affinity Capture-MS Homo sapiens
101 FITM2  
Affinity Capture-MS Homo sapiens
102 STIM1 6786
Affinity Capture-MS Homo sapiens
103 PTPLA  
Affinity Capture-MS Homo sapiens
104 ATM 472
Affinity Capture-MS Homo sapiens
105 SLC7A3  
Affinity Capture-MS Homo sapiens
106 TMEM11 8834
Affinity Capture-MS Homo sapiens
107 LPCAT3 10162
Affinity Capture-MS Homo sapiens
108 RIPK4  
Affinity Capture-MS Homo sapiens
109 SLC25A23  
Affinity Capture-MS Homo sapiens
110 SGPP1 81537
Affinity Capture-MS Homo sapiens
111 SERINC1 57515
Affinity Capture-MS Homo sapiens
112 TRAPPC1 58485
Affinity Capture-MS Homo sapiens
113 SLC35B2 347734
Affinity Capture-MS Homo sapiens
114 DHRS13  
Affinity Capture-MS Homo sapiens
115 SMDT1  
Affinity Capture-MS Homo sapiens
116 ALG8  
Affinity Capture-MS Homo sapiens
117 APOOL 139322
Affinity Capture-MS Homo sapiens
118 EIF2D 1939
Affinity Capture-MS Homo sapiens
119 DOLK 22845
Affinity Capture-MS Homo sapiens
120 CERS6  
Affinity Capture-MS Homo sapiens
121 NDUFA3  
Affinity Capture-MS Homo sapiens
122 XRCC3  
Affinity Capture-MS Homo sapiens
123 DHRS3 9249
Affinity Capture-MS Homo sapiens
124 PDZK1 5174
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
125 ALG2 85365
Affinity Capture-MS Homo sapiens
126 TAP1 6890
Affinity Capture-MS Homo sapiens
127 ALG9 79796
Affinity Capture-MS Homo sapiens
128 ORMDL2 29095
Affinity Capture-MS Homo sapiens
129 MBOAT7 79143
Affinity Capture-MS Homo sapiens
130 SLC19A2 10560
Affinity Capture-MS Homo sapiens
131 C17orf80 55028
Affinity Capture-MS Homo sapiens
132 PHF20  
Affinity Capture-MS Homo sapiens
133 GPR89A  
Affinity Capture-MS Homo sapiens
134 TRAPPC5 126003
Affinity Capture-MS Homo sapiens
135 CTDSP1 58190
Affinity Capture-MS Homo sapiens
136 ABCB8 11194
Affinity Capture-MS Homo sapiens
137 ATP2B4 493
Affinity Capture-MS Homo sapiens
138 DNAJC19 131118
Affinity Capture-MS Homo sapiens
139 CDS1  
Affinity Capture-MS Homo sapiens
140 KNTC1 9735
Affinity Capture-MS Homo sapiens
141 AGPAT9  
Affinity Capture-MS Homo sapiens
142 PIGO  
Affinity Capture-MS Homo sapiens
143 RSPRY1 89970
Affinity Capture-MS Homo sapiens
144 SLC25A40  
Affinity Capture-MS Homo sapiens
145 TSPAN15 23555
Affinity Capture-MS Homo sapiens
146 TUBB3 10381
Affinity Capture-MS Homo sapiens
147 SLC25A15  
Affinity Capture-MS Homo sapiens
148 NDUFA12 55967
Affinity Capture-MS Homo sapiens
149 GPD1L 23171
Affinity Capture-MS Homo sapiens
150 PIGU 128869
Affinity Capture-MS Homo sapiens
151 TTK 7272
Affinity Capture-MS Homo sapiens
152 AGPAT3 56894
Affinity Capture-MS Homo sapiens
153 CDYL 9425
Affinity Capture-MS Homo sapiens
154 SLC10A7  
Affinity Capture-MS Homo sapiens
155 C17orf62 79415
Affinity Capture-MS Homo sapiens
156 GPR50  
Affinity Capture-MS Homo sapiens
157 PXMP2  
Affinity Capture-MS Homo sapiens
158 HACD2 201562
Affinity Capture-MS Homo sapiens
159 ERGIC2 51290
Affinity Capture-MS Homo sapiens
160 TMEM126B 55863
Affinity Capture-MS Homo sapiens
161 SLC25A42  
Affinity Capture-MS Homo sapiens
162 PDK1 5163
Affinity Capture-MS Homo sapiens
163 ALG3 10195
Affinity Capture-MS Homo sapiens
164 SLC25A51  
Affinity Capture-MS Homo sapiens
165 SLC6A8 6535
Affinity Capture-MS Homo sapiens
166 ORAI1 84876
Affinity Capture-MS Homo sapiens
167 MTX3  
Affinity Capture-MS Homo sapiens
168 ABHD17B 51104
Affinity Capture-MS Homo sapiens
169 CAV1 857
Affinity Capture-MS Homo sapiens
170 ND4 4538
Affinity Capture-MS Homo sapiens
171 SRR 63826
Affinity Capture-MS Homo sapiens
172 C14orf2  
Affinity Capture-MS Homo sapiens
173 WRB 7485
Affinity Capture-MS Homo sapiens
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