Gene description for SLC22A4
Gene name solute carrier family 22 (organic cation/zwitterion transporter), member 4
Gene symbol SLC22A4
Other names/aliases OCTN1
Species Homo sapiens
 Database cross references - SLC22A4
ExoCarta ExoCarta_6583
Vesiclepedia VP_6583
Entrez Gene 6583
HGNC 10968
MIM 604190
UniProt Q9H015  
 SLC22A4 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SLC22A4
Molecular Function
    secondary active organic cation transmembrane transporter activity GO:0008513 TAS
    quaternary ammonium group transmembrane transporter activity GO:0015651 IDA
    nucleotide binding GO:0000166 TAS
    cation:cation antiporter activity GO:0015491 IDA
    symporter activity GO:0015293 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    PDZ domain binding GO:0030165 IPI
    carnitine transmembrane transporter activity GO:0015226 IDA
Biological Process
    body fluid secretion GO:0007589 TAS
    carnitine transport GO:0015879 IDA
    triglyceride metabolic process GO:0006641 IEA
    carnitine transmembrane transport GO:1902603 IEA
    carnitine metabolic process GO:0009437 IEA
    sodium ion transport GO:0006814 IEA
    quaternary ammonium group transport GO:0015697 IDA
    transmembrane transport GO:0055085 TAS
    organic cation transport GO:0015695 TAS
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
    apical plasma membrane GO:0016324 IDA
    plasma membrane GO:0005886 TAS
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified SLC22A4 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SLC22A4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PDZK1 5174
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which SLC22A4 is involved
PathwayEvidenceSource
Organic cation transport TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here