Gene description for SRR
Gene name serine racemase
Gene symbol SRR
Other names/aliases ILV1
ISO1
Species Homo sapiens
 Database cross references - SRR
ExoCarta ExoCarta_63826
Vesiclepedia VP_63826
Entrez Gene 63826
HGNC 14398
MIM 606477
UniProt Q9GZT4  
 SRR identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SRR
Molecular Function
    magnesium ion binding GO:0000287 IBA
    magnesium ion binding GO:0000287 IDA
    L-serine ammonia-lyase activity GO:0003941 IBA
    L-serine ammonia-lyase activity GO:0003941 IDA
    calcium ion binding GO:0005509 ISS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IBA
    ATP binding GO:0005524 IDA
    ATP binding GO:0005524 ISS
    D-serine ammonia-lyase activity GO:0008721 IEA
    glycine binding GO:0016594 ISS
    threonine racemase activity GO:0018114 IBA
    threonine racemase activity GO:0018114 ISS
    PDZ domain binding GO:0030165 IPI
    pyridoxal phosphate binding GO:0030170 IBA
    pyridoxal phosphate binding GO:0030170 IDA
    pyridoxal phosphate binding GO:0030170 ISS
    serine racemase activity GO:0030378 IBA
    serine racemase activity GO:0030378 IDA
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IPI
Biological Process
    L-serine metabolic process GO:0006563 IDA
    serine family amino acid metabolic process GO:0009069 ISS
    response to xenobiotic stimulus GO:0009410 IEA
    response to organic cyclic compound GO:0014070 IEA
    response to lipopolysaccharide GO:0032496 IEP
    pyruvate biosynthetic process GO:0042866 IDA
    D-serine metabolic process GO:0070178 IDA
    D-serine biosynthetic process GO:0070179 IBA
    D-serine biosynthetic process GO:0070179 IDA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    neuronal cell body GO:0043025 IDA
    apical part of cell GO:0045177 IEA
 Experiment description of studies that identified SRR in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SRR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TNFSF8  
Affinity Capture-MS Homo sapiens
2 SPACA1 81833
Affinity Capture-MS Homo sapiens
3 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
4 Disc1  
Affinity Capture-Western Mus musculus
5 DISC1 27185
Affinity Capture-Western Homo sapiens
6 PRKAR1A 5573
Co-fractionation Homo sapiens
7 RNF41  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
8 FCHO1  
Affinity Capture-MS Homo sapiens
9 GOLGA3 2802
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
10 OXNAD1 92106
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 SLC22A4 6583
Affinity Capture-MS Homo sapiens
12 SERBP1 26135
Affinity Capture-MS Homo sapiens
13 GRIP1  
Affinity Capture-Western Homo sapiens
14 SRR 63826
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
15 APP 351
Reconstituted Complex Homo sapiens
16 FBXO22 26263
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
17 FNDC8  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SRR is involved
PathwayEvidenceSource
Metabolism TAS Reactome
Metabolism of amino acids and derivatives TAS Reactome
Serine biosynthesis TAS Reactome





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