Gene description for FBXO22
Gene name F-box protein 22
Gene symbol FBXO22
Other names/aliases FBX22
FISTC1
Species Homo sapiens
 Database cross references - FBXO22
ExoCarta ExoCarta_26263
Vesiclepedia VP_26263
Entrez Gene 26263
HGNC 13593
MIM 609096
UniProt Q8NEZ5  
 FBXO22 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for FBXO22
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 TAS
    protein binding GO:0005515 IPI
Biological Process
    protein polyubiquitination GO:0000209 IBA
    ubiquitin-dependent protein catabolic process GO:0006511 TAS
    nucleocytoplasmic transport GO:0006913 IEA
    cellular response to starvation GO:0009267 IEA
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IBA
    protein modification process GO:0036211 TAS
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IEA
    regulation of skeletal muscle fiber development GO:0048742 IBA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytosol GO:0005829 TAS
    Z disc GO:0030018 IEA
 Experiment description of studies that identified FBXO22 in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FBXO22
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRIM21 6737
Affinity Capture-MS Homo sapiens
2 COPS5 10987
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 SERBP1 26135
Affinity Capture-MS Homo sapiens
4 BACH1 571
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
5 TTC9C 283237
Affinity Capture-MS Homo sapiens
6 UBE2H 7328
Affinity Capture-MS Homo sapiens
7 CUL1 8454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
8 SKP1 6500
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 CUL3 8452
Affinity Capture-MS Homo sapiens
10 KDM4B  
Affinity Capture-Western Homo sapiens
11 FSCN1 6624
Affinity Capture-MS Homo sapiens
12 RBX1 9978
Affinity Capture-MS Homo sapiens
13 SNAI1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
14 NCOR1  
Affinity Capture-Western Homo sapiens
15 SRR 63826
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
16 PARK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 COPS6 10980
Affinity Capture-MS Homo sapiens
18 NCOR2  
Affinity Capture-MS Homo sapiens
19 Srr  
Affinity Capture-MS Mus musculus
20 KLF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
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