Gene description for TRIM21
Gene name	tripartite motif containing 21
Gene symbol	TRIM21
Other names/aliases	RNF81 RO52 Ro/SSA SSA SSA1
Species	Homo sapiens
Database cross references - TRIM21
ExoCarta	ExoCarta_6737
Entrez Gene	6737
HGNC	11312
MIM	109092
UniProt	P19474
TRIM21 identified in exosomes derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for TRIM21

Molecular Function     RNA binding GO:0003723 IEA     protein binding GO:0005515 IPI     ubiquitin-protein transferase activity GO:0004842 IDA     DNA binding GO:0003677 IEA     zinc ion binding GO:0008270 IEA     ligase activity GO:0016874 IEA     identical protein binding GO:0042802 IPI Biological Process     regulation of type I interferon production GO:0032479 TAS     positive regulation of viral entry into host cell GO:0046598 IEA     positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IDA     innate immune response GO:0045087 TAS     positive regulation of cell cycle GO:0045787 IMP     protein trimerization GO:0070206 IDA     negative regulation of NF-kappaB transcription factor activity GO:0032088 IDA     interferon-gamma-mediated signaling pathway GO:0060333 TAS     negative regulation of protein deubiquitination GO:0090086 IMP     protein ubiquitination GO:0016567 IDA     protein monoubiquitination GO:0006513 IDA     negative regulation of viral transcription GO:0032897 IDA     protein destabilization GO:0031648 IMP     cell cycle GO:0007049 IEA     cytokine-mediated signaling pathway GO:0019221 TAS     protein polyubiquitination GO:0000209 IDA     negative regulation of viral release from host cell GO:1902187 IDA     protein autoubiquitination GO:0051865 IDA     positive regulation of type I interferon production GO:0032481 TAS Subcellular Localization     cytosol GO:0005829 TAS     SCF ubiquitin ligase complex GO:0019005 IDA     cytoplasmic mRNA processing body GO:0000932 IEA     nucleoplasm GO:0005654 IDA     cytoplasm GO:0005737 IDA     nucleus GO:0005634 IDA     ribonucleoprotein complex GO:0030529 TAS