Gene description for CD14
Gene name CD14 molecule
Gene symbol CD14
Other names/aliases -
Species Homo sapiens
 Database cross references - CD14
ExoCarta ExoCarta_929
Entrez Gene 929
HGNC 1628
MIM 158120
UniProt P08571  
 CD14 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
Urine 19056867    
 Gene ontology annotations for CD14
Molecular Function
    lipoteichoic acid binding GO:0070891 IDA
    peptidoglycan receptor activity GO:0016019 TAS
    protein binding GO:0005515 IPI
    lipopolysaccharide binding GO:0001530 IDA
    opsonin receptor activity GO:0001847 TAS
Biological Process
    response to ethanol GO:0045471 IEA
    toll-like receptor 2 signaling pathway GO:0034134 TAS
    positive regulation of cytokine secretion GO:0050715 IEA
    I-kappaB kinase/NF-kappaB signaling GO:0007249 TAS
    cellular response to lipopolysaccharide GO:0071222 IDA
    apoptotic process GO:0006915 TAS
    response to tumor necrosis factor GO:0034612 IEA
    MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS
    phagocytosis GO:0006909 TAS
    inflammatory response GO:0006954 IEA
    innate immune response GO:0045087 TAS
    positive regulation of endocytosis GO:0045807 IEA
    positive regulation of tumor necrosis factor production GO:0032760 IDA
    MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS
    cellular response to lipoteichoic acid GO:0071223 IDA
    TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS
    response to electrical stimulus GO:0051602 IEA
    toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS
    extrinsic apoptotic signaling pathway GO:0097191 TAS
    toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS
    activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 TAS
    toll-like receptor 4 signaling pathway GO:0034142 TAS
    programmed cell death GO:0012501 TAS
    cell surface receptor signaling pathway GO:0007166 TAS
    toll-like receptor signaling pathway GO:0002224 TAS
    toll-like receptor 3 signaling pathway GO:0034138 TAS
    response to heat GO:0009408 IEA
    response to magnesium ion GO:0032026 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    extracellular space GO:0005615 IDA
    extracellular region GO:0005576 TAS
    membrane raft GO:0045121 IEA
    cell surface GO:0009986 IEA
    endosome membrane GO:0010008 TAS
    anchored component of membrane GO:0031225 IEA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified CD14 in exosomes
1
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CD14
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TLR2 7097
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
2 LGALS3BP 3959
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
3 LTF 4057
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
4 CD55 1604
Affinity Capture-MS Homo sapiens
5 ITGB2 3689
Affinity Capture-MS Homo sapiens
6 LBP 3929
Invitro Homo sapiens
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