Gene description for TLR2
Gene name	toll-like receptor 2
Gene symbol	TLR2
Other names/aliases	CD282 TIL4
Species	Homo sapiens
Database cross references - TLR2
ExoCarta	ExoCarta_7097
Entrez Gene	7097
HGNC	11848
MIM	603028
UniProt	O60603
TLR2 identified in exosomes derived from the following tissue/cell type
Breast milk	17641064

Gene ontology annotations for TLR2

Molecular Function     triacyl lipopeptide binding GO:0042497 IDA     lipopolysaccharide receptor activity GO:0001875 TAS     signaling pattern recognition receptor activity GO:0008329 IDA     diacyl lipopeptide binding GO:0042498 IEA     transmembrane signaling receptor activity GO:0004888 IEA     protein binding GO:0005515 IPI     protein heterodimerization activity GO:0046982 IDA     lipoteichoic acid binding GO:0070891 IEA     peptidoglycan binding GO:0042834 IDA     receptor activity GO:0004872 IDA Biological Process     negative regulation of cell proliferation GO:0008285 IEA     negative regulation of interleukin-12 production GO:0032695 IEA     nitric oxide metabolic process GO:0046209 IEA     response to insulin GO:0032868 IEA     positive regulation of inflammatory response GO:0050729 IC     I-kappaB phosphorylation GO:0007252 IDA     positive regulation of Wnt signaling pathway GO:0030177 IMP     inflammatory response GO:0006954 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS     positive regulation of nitric oxide biosynthetic process GO:0045429 IEA     positive regulation of chemokine production GO:0032722 IDA     positive regulation of interleukin-10 production GO:0032733 IEA     cellular response to bacterial lipopeptide GO:0071221 TAS     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS     interleukin-10 production GO:0032613 IDA     toll-like receptor signaling pathway GO:0002224 TAS     signal transduction GO:0007165 TAS     negative regulation of interleukin-17 production GO:0032700 IEA     positive regulation of interleukin-8 production GO:0032757 IDA     positive regulation of leukocyte migration GO:0002687 IEA     positive regulation of macrophage cytokine production GO:0060907 IEA     cytokine secretion involved in immune response GO:0002374 IMP     positive regulation of interferon-beta production GO:0032728 ISS     defense response to Gram-positive bacterium GO:0050830 IDA     toll-like receptor 2 signaling pathway GO:0034134 TAS     positive regulation of toll-like receptor signaling pathway GO:0034123 IDA     lipopolysaccharide-mediated signaling pathway GO:0031663 TAS     chloramphenicol transport GO:0042892 IEA     positive regulation of NF-kappaB import into nucleus GO:0042346 IDA     response to molecule of fungal origin GO:0002238 IEA     immune response GO:0006955 TAS     positive regulation of cytokine secretion GO:0050715 IEA     positive regulation of interleukin-12 production GO:0032735 ISS     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     toll-like receptor 4 signaling pathway GO:0034142 TAS     negative regulation of growth of symbiont in host GO:0044130 IEA     detection of diacyl bacterial lipopeptide GO:0042496 IDA     positive regulation of tumor necrosis factor production GO:0032760 ISS     cellular response to diacyl bacterial lipopeptide GO:0071726 IDA     apoptotic process GO:0006915 TAS     detection of triacyl bacterial lipopeptide GO:0042495 IDA     positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA     cellular response to lipoteichoic acid GO:0071223 IDA     cellular response to peptidoglycan GO:0071224 IEA     positive regulation of interleukin-6 production GO:0032755 IDA     central nervous system myelin formation GO:0032289 IEA     positive regulation of interleukin-18 production GO:0032741 ISS     induction by symbiont of defense-related host nitric oxide production GO:0052063 IEA     innate immune response GO:0045087 TAS     positive regulation of tumor necrosis factor biosynthetic process GO:0042535 IEA     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     response to toxic substance GO:0009636 IEA     response to fatty acid GO:0070542 IEA     positive regulation of oligodendrocyte differentiation GO:0048714 IEA     cell surface pattern recognition receptor signaling pathway GO:0002752 IEA     cellular response to triacyl bacterial lipopeptide GO:0071727 IDA     response to progesterone GO:0032570 IEA     response to hypoxia GO:0001666 IEA     positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 ISS     microglial cell activation GO:0001774 IEA     leukotriene metabolic process GO:0006691 IEA Subcellular Localization     cell projection GO:0042995 IEA     plasma membrane GO:0005886 TAS     Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 IDA     Toll-like receptor 2-Toll-like receptor 6 protein complex GO:0035355 IEA     integral component of plasma membrane GO:0005887 TAS     cytoplasm GO:0005737 IDA     cell body GO:0044297 IEA     cell surface GO:0009986 IDA     external side of plasma membrane GO:0009897 IEA