Gene description for PPP1R12B
Gene name protein phosphatase 1, regulatory subunit 12B
Gene symbol PPP1R12B
Other names/aliases MYPT2
PP1bp55
Species Homo sapiens
 Database cross references - PPP1R12B
ExoCarta ExoCarta_4660
Vesiclepedia VP_4660
Entrez Gene 4660
HGNC 7619
MIM 603768
UniProt O60237  
 PPP1R12B identified in sEVs derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for PPP1R12B
Molecular Function
    enzyme inhibitor activity GO:0004857 IBA
    protein binding GO:0005515 IPI
    enzyme activator activity GO:0008047 TAS
    myosin phosphatase regulator activity GO:0017020 IBA
    protein kinase binding GO:0019901 IEA
Biological Process
    regulation of muscle contraction GO:0006937 TAS
    signal transduction GO:0007165 IEA
    neuron projection morphogenesis GO:0048812 IBA
Subcellular Localization
    stress fiber GO:0001725 IEA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
    Z disc GO:0030018 IBA
    Z disc GO:0030018 ISS
    A band GO:0031672 IBA
    A band GO:0031672 ISS
 Experiment description of studies that identified PPP1R12B in sEVs
1
Experiment ID 274
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for PPP1R12B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD14 929
Affinity Capture-MS Homo sapiens
2 ANLN 54443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CCAR2 57805
Cross-Linking-MS (XL-MS) Homo sapiens
4 ASB3 51130
Affinity Capture-MS Homo sapiens
5 NOTCH3 4854
Affinity Capture-MS Homo sapiens
6 ANKFY1 51479
Affinity Capture-MS Homo sapiens
7 PPP1CB 5500
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
8 ANK2 287
Affinity Capture-MS Homo sapiens
9 Myh9 17886
Affinity Capture-MS Mus musculus
10 ANK1 286
Affinity Capture-MS Homo sapiens
11 ANKHD1-EIF4EBP3  
Affinity Capture-MS Homo sapiens
12 KIF14 9928
Affinity Capture-MS Homo sapiens
13 HSPA8 3312
Affinity Capture-Western Homo sapiens
14 TNKS 8658
Affinity Capture-MS Homo sapiens
15 PPP1R13L 10848
Affinity Capture-MS Homo sapiens
16 FKBP6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 E2F4  
Affinity Capture-MS Homo sapiens
18 CTNNB1 1499
Affinity Capture-MS Homo sapiens
19 PPP1CA 5499
Affinity Capture-MS Homo sapiens
20 Myo1c 17913
Affinity Capture-MS Mus musculus
21 MYO18A 399687
Affinity Capture-MS Homo sapiens
22 SKP1 6500
Co-fractionation Homo sapiens
23 GMDS 2762
Affinity Capture-MS Homo sapiens
24 ISCU 23479
Affinity Capture-MS Homo sapiens
25 MYO19  
Affinity Capture-MS Homo sapiens
26 ANKRD17 26057
Affinity Capture-MS Homo sapiens
27 TNKS2 80351
Affinity Capture-MS Homo sapiens
28 PPP6R2 9701
Affinity Capture-MS Homo sapiens
29 Actb 11461
Affinity Capture-MS Mus musculus
30 NUAK1  
Affinity Capture-MS Homo sapiens
31 ANKRD28 23243
Affinity Capture-MS Homo sapiens
32 IL16  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
33 Myh10 77579
Affinity Capture-MS Mus musculus
34 PSMD14 10213
Affinity Capture-MS Homo sapiens
35 PPP1CC 5501
Affinity Capture-MS Homo sapiens
36 HIF1AN 55662
Affinity Capture-MS Homo sapiens
37 NOTCH1 4851
Affinity Capture-MS Homo sapiens
38 Cep72  
Affinity Capture-MS Mus musculus
39 PPP1R12A 4659
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
40 SYNPO 11346
Affinity Capture-MS Homo sapiens
41 ANKHD1 54882
Affinity Capture-MS Homo sapiens
42 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
43 USP47 55031
Affinity Capture-MS Homo sapiens
44 MYH9 4627
Affinity Capture-MS Homo sapiens
45 LRRC1 55227
Affinity Capture-MS Homo sapiens
46 NOTCH2 4853
Affinity Capture-MS Homo sapiens
47 COPS6 10980
Affinity Capture-MS Homo sapiens
48 IMPACT 55364
Affinity Capture-MS Homo sapiens
49 DNPEP 23549
Affinity Capture-MS Homo sapiens
50 IQGAP1 8826
Affinity Capture-MS Homo sapiens
51 ANK3  
Affinity Capture-MS Homo sapiens
52 TPP2 7174
Affinity Capture-MS Homo sapiens
53 SIK2  
Affinity Capture-MS Homo sapiens
54 Ppp1cb 19046
Affinity Capture-MS Mus musculus
55 ASB1 51665
Affinity Capture-MS Homo sapiens
56 BBS1 582
Affinity Capture-MS Homo sapiens
57 PRKG1 5592
Two-hybrid Homo sapiens
View the network image/svg+xml



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