Gene description for HIF1AN
Gene name hypoxia inducible factor 1, alpha subunit inhibitor
Gene symbol HIF1AN
Other names/aliases FIH1
Species Homo sapiens
 Database cross references - HIF1AN
ExoCarta ExoCarta_55662
Vesiclepedia VP_55662
Entrez Gene 55662
HGNC 17113
MIM 606615
UniProt Q9NWT6  
 HIF1AN identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for HIF1AN
Molecular Function
    transcription corepressor activity GO:0003714 IDA
    Notch binding GO:0005112 IPI
    protein binding GO:0005515 IPI
    ferrous iron binding GO:0008198 IDA
    zinc ion binding GO:0008270 IDA
    oxygen sensor activity GO:0019826 NAS
    carboxylic acid binding GO:0031406 IDA
    peptidyl-histidine dioxygenase activity GO:0036139 IBA
    peptidyl-histidine dioxygenase activity GO:0036139 IDA
    [protein]-asparagine 3-dioxygenase activity GO:0036140 IBA
    [protein]-asparagine 3-dioxygenase activity GO:0036140 IDA
    [protein]-asparagine 3-dioxygenase activity GO:0036140 IMP
    protein homodimerization activity GO:0042803 IDA
    NF-kappaB binding GO:0051059 IPI
    peptidyl-aspartic acid 3-dioxygenase activity GO:0062101 IDA
    ankyrin repeat binding GO:0071532 IPI
Biological Process
    regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 IBA
    positive regulation of myoblast differentiation GO:0045663 IMP
    negative regulation of Notch signaling pathway GO:0045746 IBA
    negative regulation of Notch signaling pathway GO:0045746 IDA
    negative regulation of DNA-templated transcription GO:0045892 IEA
    positive regulation of vasculogenesis GO:2001214 NAS
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified HIF1AN in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HIF1AN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIAH1  
Affinity Capture-Western Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 PIP4K2C 79837
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 CCDC94  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 NOTCH3 4854
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 ZFP36L2 678
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 HDAC2 3066
Reconstituted Complex Homo sapiens
8 ANKK1  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
9 REL 5966
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 STYK1  
Affinity Capture-MS Homo sapiens
11 UBA1 7317
Affinity Capture-MS Homo sapiens
12 APBA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 VHL  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
14 ANKRD39  
Affinity Capture-MS Homo sapiens
15 ANKS1A 23294
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 ANKRD50 57182
Two-hybrid Homo sapiens
17 EIF4ENIF1 56478
Affinity Capture-MS Homo sapiens
18 HDAC3 8841
Reconstituted Complex Homo sapiens
19 MLLT4 4301
Affinity Capture-MS Homo sapiens
20 HIRIP3  
Affinity Capture-MS Homo sapiens
21 CHCHD2  
Affinity Capture-MS Homo sapiens
22 ANKRD49  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 RNASEL 6041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 STAT3 6774
Affinity Capture-MS Homo sapiens
25 FEM1B 10116
Two-hybrid Homo sapiens
26 ASB9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
27 KRT5 3852
Affinity Capture-MS Homo sapiens
28 OTUD7B 56957
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 PIP4K2B 8396
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 C2orf44  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 ASB4  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 KLHL20  
Affinity Capture-MS Homo sapiens
33 ANK2 287
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 FEM1A  
Affinity Capture-MS Homo sapiens
35 KIAA1804  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 ANKRD12  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
37 CHST7  
Affinity Capture-MS Homo sapiens
38 INVS  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
39 GMDS 2762
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 EIF4G1 1981
Affinity Capture-MS Homo sapiens
41 EMD 2010
Affinity Capture-MS Homo sapiens
42 Mib1  
Two-hybrid Mus musculus
43 HIF1AN 55662
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
44 TXLNG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 TUBA1C 84790
Affinity Capture-MS Homo sapiens
46 ASB10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 ANKEF1  
Affinity Capture-MS Homo sapiens
48 HECTD1 25831
Affinity Capture-MS Homo sapiens
49 NFKB2 4791
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 ANKRD44 91526
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 ST13 6767
Affinity Capture-MS Homo sapiens
52 PPP1R12B 4660
Affinity Capture-MS Homo sapiens
53 ZRANB1 54764
Affinity Capture-MS Homo sapiens
54 ASB5  
Affinity Capture-MS Homo sapiens
55 ANKRD27  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 TNNI3K  
Affinity Capture-MS Homo sapiens
57 ANKRD55  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 XPO1 7514
Affinity Capture-MS Homo sapiens
59 NDUFA9 4704
Affinity Capture-MS Homo sapiens
60 TNKS 8658
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 CCT6A 908
Affinity Capture-MS Homo sapiens
62 NFKBIA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 ASB6 140459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 RPRD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 TNKS2 80351
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 EEF1B2 1933
Affinity Capture-MS Homo sapiens
67 UACA 55075
Two-hybrid Homo sapiens
68 RIPK4  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
69 ASB16 92591
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 ANKRD52 283373
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 FDPS 2224
Affinity Capture-MS Homo sapiens
72 USP24 23358
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 NFKB1 4790
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
74 SKIV2L2 23517
Affinity Capture-MS Homo sapiens
75 PLA2G6 8398
Affinity Capture-MS Homo sapiens
76 FBF1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 HLA-A 3105
Affinity Capture-MS Homo sapiens
78 CLDN20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 OSBPL1A 114876
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 HIF1A 3091
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
81 TXLNA 200081
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 UBE3A 7337
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 ASB3 51130
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 TP53BP2  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
85 ANKFY1 51479
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 ANKRD37 353322
Two-hybrid Homo sapiens
87 ASB13  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
88 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
89 FYCO1 79443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 HDAC1 3065
Reconstituted Complex Homo sapiens
91 OTUB1 55611
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 MAGEA9  
Affinity Capture-MS Homo sapiens
93 DDX58 23586
Affinity Capture-RNA Homo sapiens
94 CDK1 983
Affinity Capture-MS Homo sapiens
95 ASB8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 TBK1 29110
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 ACAP3 116983
Affinity Capture-MS Homo sapiens
98 OSBPL3 26031
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 ANKDD1A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 ACBD6 84320
Affinity Capture-MS Homo sapiens
101 RPS27L 51065
Affinity Capture-MS Homo sapiens
102 SERBP1 26135
Affinity Capture-MS Homo sapiens
103 ANK3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 NFKBIB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 MTL5  
Affinity Capture-MS Homo sapiens
106 ASB7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
107 CASKIN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 HUNK  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HIF1AN is involved
PathwayEvidenceSource
Cellular response to hypoxia TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome





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