Gene description for UACA
Gene name uveal autoantigen with coiled-coil domains and ankyrin repeats
Gene symbol UACA
Other names/aliases NUCLING
Species Homo sapiens
 Database cross references - UACA
ExoCarta ExoCarta_55075
Entrez Gene 55075
HGNC 15947
MIM 612516
UniProt Q9BZF9  
 UACA identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Urine 19056867    
 Gene ontology annotations for UACA
Molecular Function
    molecular_function GO:0003674 ND
    protein binding GO:0005515 IPI
Biological Process
    response to UV GO:0009411 IEA
    negative regulation of NF-kappaB import into nucleus GO:0042347 IEA
    negative regulation of inflammatory response GO:0050728 IEA
    positive regulation of protein import into nucleus GO:0042307 IEA
    regulation of NIK/NF-kappaB signaling GO:1901222 IEA
    intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 IEA
    biological_process GO:0008150 ND
    intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IEA
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
    cytoplasm GO:0005737 IDA
    membrane GO:0016020 IEA
    nuclear envelope GO:0005635 IEA
    extracellular exosome GO:0070062 IDA
    nucleus GO:0005634 IDA
    mitochondrion GO:0005739 IDA
    extracellular region GO:0005576 NAS
    apoptosome GO:0043293 IEA
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified UACA in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for UACA
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which UACA is involved
No pathways found

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