Gene description for TRIM33
Gene name tripartite motif containing 33
Gene symbol TRIM33
Other names/aliases ECTO
PTC7
RFG7
TF1G
TIF1G
TIF1GAMMA
TIFGAMMA
Species Homo sapiens
 Database cross references - TRIM33
ExoCarta ExoCarta_51592
Vesiclepedia VP_51592
Entrez Gene 51592
HGNC 16290
MIM 605769
UniProt Q9UPN9  
 TRIM33 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TRIM33
Molecular Function
    DNA binding GO:0003677 IEA
    ubiquitin-protein transferase activity GO:0004842 TAS
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    co-SMAD binding GO:0070410 IPI
    R-SMAD binding GO:0070412 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 TAS
    protein ubiquitination GO:0016567 IDA
    protein ubiquitination GO:0016567 IEA
    regulation of transforming growth factor beta receptor signaling pathway GO:0017015 IDA
    negative regulation of BMP signaling pathway GO:0030514 IDA
    negative regulation of DNA-templated transcription GO:0045892 NAS
Subcellular Localization
    chromatin GO:0000785 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified TRIM33 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TRIM33
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SSBP4  
Affinity Capture-MS Homo sapiens
2 SLFN11 91607
Affinity Capture-MS Homo sapiens
3 MCM3 4172
Co-fractionation Homo sapiens
4 KRT37 8688
Affinity Capture-MS Homo sapiens
5 CNKSR1  
Affinity Capture-MS Homo sapiens
6 PER1  
Affinity Capture-MS Homo sapiens
7 FBN2 2201
Affinity Capture-MS Homo sapiens
8 SKIV2L 6499
Affinity Capture-MS Homo sapiens
9 KPNA1 3836
Affinity Capture-MS Homo sapiens
10 ZNF324B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 POGZ 23126
Affinity Capture-MS Homo sapiens
12 TIMM50 92609
Affinity Capture-MS Homo sapiens
13 ANAPC5 51433
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
14 FHL3 2275
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 SHFM1 7979
Affinity Capture-MS Homo sapiens
16 TRIM33 51592
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
17 SSB 6741
Affinity Capture-MS Homo sapiens
18 CALM1 801
Affinity Capture-MS Homo sapiens
19 LOXL4 84171
Affinity Capture-MS Homo sapiens
20 SSBP2  
Affinity Capture-MS Homo sapiens
21 ZBTB1  
Affinity Capture-MS Homo sapiens
22 RABGGTB 5876
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 ANKRD28 23243
Affinity Capture-MS Homo sapiens
24 ELF4 2000
Proximity Label-MS Homo sapiens
25 MYOD1  
Proximity Label-MS Homo sapiens
26 LRPPRC 10128
Co-fractionation Homo sapiens
27 BTBD18  
Affinity Capture-MS Homo sapiens
28 LMO2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 ZNF44  
Affinity Capture-MS Homo sapiens
30 LRP2 4036
Affinity Capture-MS Homo sapiens
31 PNMA1 9240
Affinity Capture-MS Homo sapiens
32 NCOR1  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
33 TRIM28 10155
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 KLF8  
Proximity Label-MS Homo sapiens
35 TCF12  
Affinity Capture-MS Homo sapiens
36 KIF5B 3799
Co-fractionation Homo sapiens
37 OSBP 5007
Co-fractionation Homo sapiens
38 FZR1  
Affinity Capture-Western Homo sapiens
39 ERC1 23085
Affinity Capture-MS Homo sapiens
40 ZNF460  
Affinity Capture-MS Homo sapiens
41 VCP 7415
Affinity Capture-MS Homo sapiens
42 GSPT1 2935
Co-fractionation Homo sapiens
43 THRSP  
Affinity Capture-MS Homo sapiens
44 TMX3 54495
Affinity Capture-MS Homo sapiens
45 CDC27 996
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
46 ANAPC7 51434
Affinity Capture-Western Homo sapiens
47 NID2 22795
Affinity Capture-MS Homo sapiens
48 POLR2C 5432
Affinity Capture-MS Homo sapiens
49 KLHL20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 LHX4  
Proximity Label-MS Homo sapiens
51 CTNNA1 1495
Co-fractionation Homo sapiens
52 ADCK3  
Affinity Capture-MS Homo sapiens
53 ZNF418  
Affinity Capture-MS Homo sapiens
54 ASF1A 25842
Proximity Label-MS Homo sapiens
55 MAD2L1 4085
Affinity Capture-MS Homo sapiens
56 SOD1 6647
Affinity Capture-MS Homo sapiens
57 AOX1 316
Affinity Capture-MS Homo sapiens
58 HSPA8 3312
Affinity Capture-MS Homo sapiens
59 YWHAB 7529
Co-fractionation Homo sapiens
60 PSME3 10197
Affinity Capture-MS Homo sapiens
61 RBMX 27316
Co-fractionation Homo sapiens
62 RUNX1  
Affinity Capture-MS Homo sapiens
63 TTC37 9652
Affinity Capture-MS Homo sapiens
64 DGKE  
Affinity Capture-MS Homo sapiens
65 NUP62 23636
Affinity Capture-MS Homo sapiens
66 LYL1  
Affinity Capture-MS Homo sapiens
67 RPA3 6119
Proximity Label-MS Homo sapiens
68 KRT39  
Affinity Capture-MS Homo sapiens
69 CDC23 8697
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
70 C9orf78 51759
Affinity Capture-MS Homo sapiens
71 SKI 6497
Affinity Capture-MS Homo sapiens
72 QPRT 23475
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 FGA 2243
Affinity Capture-MS Homo sapiens
74 GGCX 2677
Affinity Capture-MS Homo sapiens
75 NT5DC2 64943
Affinity Capture-MS Homo sapiens
76 TRIM24  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 GPX1 2876
Affinity Capture-MS Homo sapiens
78 CBX3 11335
Proximity Label-MS Homo sapiens
79 UBE2I 7329
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
80 UNC80 285175
Affinity Capture-MS Homo sapiens
81 HAO2  
Affinity Capture-MS Homo sapiens
82 TRIM21 6737
Affinity Capture-MS Homo sapiens
83 NTRK1 4914
Affinity Capture-MS Homo sapiens
84 ZNF333  
Affinity Capture-MS Homo sapiens
85 DCAF7 10238
Affinity Capture-MS Homo sapiens
86 SMAD3 4088
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
87 CHEK1  
Affinity Capture-MS Homo sapiens
88 SUMO2 6613
Affinity Capture-MS Homo sapiens
89 PYCRL 65263
Affinity Capture-MS Homo sapiens
90 SMAD2 4087
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
91 RFC4 5984
Co-fractionation Homo sapiens
92 PML 5371
Affinity Capture-MS Homo sapiens
93 ANAPC4 29945
Affinity Capture-Western Homo sapiens
94 UBE2D3 7323
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
95 DBT 1629
Affinity Capture-MS Homo sapiens
96 SDF4 51150
Affinity Capture-MS Homo sapiens
97 SAT1  
Affinity Capture-MS Homo sapiens
98 VDAC2 7417
Affinity Capture-MS Homo sapiens
99 CEBPA  
Proximity Label-MS Homo sapiens
Protein-peptide Homo sapiens
100 SOX17  
Proximity Label-MS Homo sapiens
101 KIAA1551  
Affinity Capture-MS Homo sapiens
102 SP100 6672
Affinity Capture-MS Homo sapiens
103 WDYHV1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 SOX7  
Proximity Label-MS Homo sapiens
105 ZNF747  
Affinity Capture-MS Homo sapiens
106 FOXF2  
Affinity Capture-MS Homo sapiens
107 UBE2N 7334
Reconstituted Complex Homo sapiens
108 SLX4  
Affinity Capture-MS Homo sapiens
109 NELL2  
Affinity Capture-MS Homo sapiens
110 CCNA2 890
Affinity Capture-Western Homo sapiens
111 ZNF484  
Affinity Capture-MS Homo sapiens
112 CBFA2T3  
Affinity Capture-MS Homo sapiens
113 LHX6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 ASS1 445
Affinity Capture-MS Homo sapiens
115 BCKDHB 594
Affinity Capture-MS Homo sapiens
116 XPO1 7514
Affinity Capture-MS Homo sapiens
117 LMNB1 4001
Co-fractionation Homo sapiens
118 BAG2 9532
Affinity Capture-MS Homo sapiens
119 EPAS1  
Affinity Capture-MS Homo sapiens
120 LCE3D  
Affinity Capture-MS Homo sapiens
121 TAL1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
122 CRYAB 1410
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
123 CTNNB1 1499
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
124 GCDH 2639
Affinity Capture-MS Homo sapiens
125 CDC16 8881
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 FOXI1  
Affinity Capture-MS Homo sapiens
127 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 UBE2E1  
Reconstituted Complex Homo sapiens
129 DPP7 29952
Affinity Capture-MS Homo sapiens
130 UACA 55075
Affinity Capture-MS Homo sapiens
131 RCN1 5954
Affinity Capture-MS Homo sapiens
132 TGM7  
Affinity Capture-MS Homo sapiens
133 JUN 3725
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 HNF4A  
Proximity Label-MS Homo sapiens
135 UBE2D2 7322
Reconstituted Complex Homo sapiens
136 MAPK6  
Affinity Capture-MS Homo sapiens
137 Nfe2l2  
Affinity Capture-MS Mus musculus
138 C12orf74  
Affinity Capture-MS Homo sapiens
139 FOS 2353
Proximity Label-MS Homo sapiens
140 MYC  
Proximity Label-MS Homo sapiens
141 KCTD17 79734
Affinity Capture-MS Homo sapiens
142 SOHLH1  
Affinity Capture-MS Homo sapiens
143 TBL1X 6907
Co-fractionation Homo sapiens
144 TRAF2 7186
Affinity Capture-MS Homo sapiens
145 DNAJC10 54431
Affinity Capture-MS Homo sapiens
146 RCN2 5955
Affinity Capture-MS Homo sapiens
147 ACY1 95
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 ZNF43  
Affinity Capture-MS Homo sapiens
149 DCAF15  
Affinity Capture-MS Homo sapiens
150 NANOG  
Affinity Capture-MS Homo sapiens
151 ZNF776  
Affinity Capture-MS Homo sapiens
152 ANGEL1  
Affinity Capture-MS Homo sapiens
153 SUPT16H 11198
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
154 TRIM4 89122
Affinity Capture-MS Homo sapiens
155 TPM3 7170
Affinity Capture-MS Homo sapiens
156 MLKL 197259
Affinity Capture-MS Homo sapiens
157 RRM1 6240
Affinity Capture-MS Homo sapiens
158 PELO 53918
Affinity Capture-MS Homo sapiens
159 CRYAA 1409
Affinity Capture-MS Homo sapiens
160 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
161 CDC20 991
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
162 HSPB2  
Affinity Capture-MS Homo sapiens
163 FAM53C 51307
Affinity Capture-MS Homo sapiens
164 SKIL  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
165 ELF5  
Proximity Label-MS Homo sapiens
166 TUBG1 7283
Affinity Capture-MS Homo sapiens
167 MTA1 9112
Co-fractionation Homo sapiens
168 PDIA4 9601
Affinity Capture-MS Homo sapiens
169 TRIM52  
Affinity Capture-MS Homo sapiens
170 CALU 813
Affinity Capture-MS Homo sapiens
171 HDAC6 10013
Affinity Capture-MS Homo sapiens
172 NLGN3  
Two-hybrid Homo sapiens
173 CHAMP1  
Affinity Capture-MS Homo sapiens
174 Trim24  
Two-hybrid Mus musculus
175 GFOD1  
Affinity Capture-MS Homo sapiens
176 KPNA6 23633
Affinity Capture-MS Homo sapiens
177 BUB1B  
Affinity Capture-Western Homo sapiens
178 SMAD4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
179 ANAPC1 64682
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
180 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
181 PJA2  
Affinity Capture-MS Homo sapiens
182 CHD1L 9557
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
183 ZNF764 92595
Affinity Capture-MS Homo sapiens
184 NUP35 129401
Proximity Label-MS Homo sapiens
185 MAGEA9  
Affinity Capture-MS Homo sapiens
186 RUNX1T1  
Affinity Capture-MS Homo sapiens
187 EDEM3 80267
Affinity Capture-MS Homo sapiens
188 SSBP3  
Affinity Capture-MS Homo sapiens
189 ESR1  
Affinity Capture-MS Homo sapiens
190 NUP50 10762
Proximity Label-MS Homo sapiens
191 TRIM37  
Proximity Label-MS Homo sapiens
192 ZIM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
193 TCF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
194 LDB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
195 KRT38 8687
Affinity Capture-MS Homo sapiens
196 RNF31 55072
Affinity Capture-MS Homo sapiens
197 ZFP82  
Affinity Capture-MS Homo sapiens
198 CDK9 1025
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
199 DHX33  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
200 SSSCA1 10534
Affinity Capture-MS Homo sapiens
201 TCF3  
Affinity Capture-MS Homo sapiens
202 PNMA2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
203 CEP78 84131
Affinity Capture-MS Homo sapiens
204 BRD1 23774
Affinity Capture-MS Homo sapiens
205 SHARPIN  
Affinity Capture-MS Homo sapiens
206 ERG  
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
207 PEX5 5830
Affinity Capture-MS Homo sapiens
208 HIST1H3A 8350
Protein-peptide Homo sapiens
209 GNB2L1 10399
Affinity Capture-MS Homo sapiens
210 AR 367
Proximity Label-MS Homo sapiens
211 SSRP1 6749
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
212 CCT8L2  
Affinity Capture-MS Homo sapiens
213 SP7  
Proximity Label-MS Homo sapiens
214 CAV1 857
Affinity Capture-MS