ExoCarta: Gene summary

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Gene description for TRIM33
Gene name	tripartite motif containing 33
Gene symbol	TRIM33
Other names/aliases	ECTO PTC7 RFG7 TF1G TIF1G TIF1GAMMA TIFGAMMA
Species	Homo sapiens
Database cross references - TRIM33
ExoCarta	ExoCarta_51592
Vesiclepedia	VP_51592
Entrez Gene	51592
HGNC	16290
MIM	605769
UniProt	Q9UPN9
TRIM33 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942

Gene ontology annotations for TRIM33

Molecular Function
	DNA binding	GO:0003677	IEA
	ubiquitin-protein transferase activity	GO:0004842	TAS
	protein binding	GO:0005515	IPI
	zinc ion binding	GO:0008270	IEA
	co-SMAD binding	GO:0070410	IPI
	R-SMAD binding	GO:0070412	IPI
Biological Process
	negative regulation of transcription by RNA polymerase II	GO:0000122	TAS
	protein ubiquitination	GO:0016567	IDA
	protein ubiquitination	GO:0016567	IEA
	regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	IDA
	negative regulation of BMP signaling pathway	GO:0030514	IDA
	negative regulation of DNA-templated transcription	GO:0045892	NAS
Subcellular Localization
	chromatin	GO:0000785	IBA
	nucleus	GO:0005634	IDA
	nucleoplasm	GO:0005654	TAS

Experiment description of studies that identified TRIM33 in sEVs

Experiment ID

489

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 6

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

490

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 7

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

491

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

492

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 9

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Protein-protein interactions for TRIM33

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

SSBP4

Affinity Capture-MS

Homo sapiens

SLFN11

91607

Affinity Capture-MS

Homo sapiens

MCM3

4172

Co-fractionation

Homo sapiens

KRT37

8688

Affinity Capture-MS

Homo sapiens

CNKSR1

Affinity Capture-MS

Homo sapiens

PER1

Affinity Capture-MS

Homo sapiens

FBN2

2201

Affinity Capture-MS

Homo sapiens

SKIV2L

6499

Affinity Capture-MS

Homo sapiens

KPNA1

3836

Affinity Capture-MS

Homo sapiens

ZNF324B

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

POGZ

23126

Affinity Capture-MS

Homo sapiens

TIMM50

92609

Affinity Capture-MS

Homo sapiens

ANAPC5

51433

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

FHL3

2275

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SHFM1

7979

Affinity Capture-MS

Homo sapiens

TRIM33

51592

Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens

SSB

6741

Affinity Capture-MS

Homo sapiens

CALM1

801

Affinity Capture-MS

Homo sapiens

LOXL4

84171

Affinity Capture-MS

Homo sapiens

SSBP2

Affinity Capture-MS

Homo sapiens

ZBTB1

Affinity Capture-MS

Homo sapiens

RABGGTB

5876

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ANKRD28

23243

Affinity Capture-MS

Homo sapiens

ELF4

2000

Proximity Label-MS

Homo sapiens

MYOD1

Proximity Label-MS

Homo sapiens

LRPPRC

10128

Co-fractionation

Homo sapiens

BTBD18

Affinity Capture-MS

Homo sapiens

LMO2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ZNF44

Affinity Capture-MS

Homo sapiens

LRP2

4036

Affinity Capture-MS

Homo sapiens

PNMA1

9240

Affinity Capture-MS

Homo sapiens

NCOR1

Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens

TRIM28

10155

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

KLF8

Proximity Label-MS

Homo sapiens

TCF12

Affinity Capture-MS

Homo sapiens

KIF5B

3799

Co-fractionation

Homo sapiens

OSBP

5007

Co-fractionation

Homo sapiens

FZR1

Affinity Capture-Western

Homo sapiens

ERC1

23085

Affinity Capture-MS

Homo sapiens

ZNF460

Affinity Capture-MS

Homo sapiens

VCP

7415

Affinity Capture-MS

Homo sapiens

GSPT1

2935

Co-fractionation

Homo sapiens

THRSP

Affinity Capture-MS

Homo sapiens

TMX3

54495

Affinity Capture-MS

Homo sapiens

CDC27

996

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

ANAPC7

51434

Affinity Capture-Western

Homo sapiens

NID2

22795

Affinity Capture-MS

Homo sapiens

POLR2C

5432

Affinity Capture-MS

Homo sapiens

KLHL20

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

LHX4

Proximity Label-MS

Homo sapiens

CTNNA1

1495

Co-fractionation

Homo sapiens

ADCK3

Affinity Capture-MS

Homo sapiens

ZNF418

Affinity Capture-MS

Homo sapiens

ASF1A

25842

Proximity Label-MS

Homo sapiens

MAD2L1

4085

Affinity Capture-MS

Homo sapiens

SOD1

6647

Affinity Capture-MS

Homo sapiens

AOX1

316

Affinity Capture-MS

Homo sapiens

HSPA8

3312

Affinity Capture-MS

Homo sapiens

YWHAB

7529

Co-fractionation

Homo sapiens

PSME3

10197

Affinity Capture-MS

Homo sapiens

RBMX

27316

Co-fractionation

Homo sapiens

RUNX1

Affinity Capture-MS

Homo sapiens

TTC37

9652

Affinity Capture-MS

Homo sapiens

DGKE

Affinity Capture-MS

Homo sapiens

NUP62

23636

Affinity Capture-MS

Homo sapiens

LYL1

Affinity Capture-MS

Homo sapiens

RPA3

6119

Proximity Label-MS

Homo sapiens

KRT39

Affinity Capture-MS

Homo sapiens

CDC23

8697

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

C9orf78

51759

Affinity Capture-MS

Homo sapiens

SKI

6497

Affinity Capture-MS

Homo sapiens

QPRT

23475

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

FGA

2243

Affinity Capture-MS

Homo sapiens

GGCX

2677

Affinity Capture-MS

Homo sapiens

NT5DC2

64943

Affinity Capture-MS

Homo sapiens

TRIM24

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

GPX1

2876

Affinity Capture-MS

Homo sapiens

CBX3

11335

Proximity Label-MS

Homo sapiens

UBE2I

7329

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

UNC80

285175

Affinity Capture-MS

Homo sapiens

HAO2

Affinity Capture-MS

Homo sapiens

TRIM21

6737

Affinity Capture-MS

Homo sapiens

NTRK1

4914

Affinity Capture-MS

Homo sapiens

ZNF333

Affinity Capture-MS

Homo sapiens

DCAF7

10238

Affinity Capture-MS

Homo sapiens

SMAD3

4088

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

CHEK1

Affinity Capture-MS

Homo sapiens

SUMO2

6613

Affinity Capture-MS

Homo sapiens

PYCRL

65263

Affinity Capture-MS

Homo sapiens

SMAD2

4087

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

RFC4

5984

Co-fractionation

Homo sapiens

PML

5371

Affinity Capture-MS

Homo sapiens

ANAPC4

29945

Affinity Capture-Western

Homo sapiens

UBE2D3

7323

Reconstituted Complex		Homo sapiens
Reconstituted Complex		Homo sapiens

DBT

1629

Affinity Capture-MS

Homo sapiens

SDF4

51150

Affinity Capture-MS

Homo sapiens

SAT1

Affinity Capture-MS

Homo sapiens

VDAC2

7417

Affinity Capture-MS

Homo sapiens

CEBPA

Proximity Label-MS		Homo sapiens
Protein-peptide		Homo sapiens

100

SOX17

Proximity Label-MS

Homo sapiens

101

KIAA1551

Affinity Capture-MS

Homo sapiens

102

SP100

6672

Affinity Capture-MS

Homo sapiens

103

WDYHV1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

104

SOX7

Proximity Label-MS

Homo sapiens

105

ZNF747

Affinity Capture-MS

Homo sapiens

106

FOXF2

Affinity Capture-MS

Homo sapiens

107

UBE2N

7334

Reconstituted Complex

Homo sapiens

108

SLX4

Affinity Capture-MS

Homo sapiens

109

NELL2

Affinity Capture-MS

Homo sapiens

110

CCNA2

890

Affinity Capture-Western

Homo sapiens

111

ZNF484

Affinity Capture-MS

Homo sapiens

112

CBFA2T3

Affinity Capture-MS

Homo sapiens

113

LHX6

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

114

ASS1

445

Affinity Capture-MS

Homo sapiens

115

BCKDHB

594

Affinity Capture-MS

Homo sapiens

116

XPO1

7514

Affinity Capture-MS

Homo sapiens

117

LMNB1

4001

Co-fractionation

Homo sapiens

118

BAG2

9532

Affinity Capture-MS

Homo sapiens

119

EPAS1

Affinity Capture-MS

Homo sapiens

120

LCE3D

Affinity Capture-MS

Homo sapiens

121

TAL1

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

122

CRYAB

1410

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

123

CTNNB1

1499

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens

124

GCDH

2639

Affinity Capture-MS

Homo sapiens

125

CDC16

8881

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

126

FOXI1

Affinity Capture-MS

Homo sapiens

127

CUL3

8452

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

128

UBE2E1

Reconstituted Complex

Homo sapiens

129

DPP7

29952

Affinity Capture-MS

Homo sapiens

130

UACA

55075

Affinity Capture-MS

Homo sapiens

131

RCN1

5954

Affinity Capture-MS

Homo sapiens

132

TGM7

Affinity Capture-MS

Homo sapiens

133

JUN

3725

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

134

HNF4A

Proximity Label-MS

Homo sapiens

135

UBE2D2

7322

Reconstituted Complex

Homo sapiens

136

MAPK6

Affinity Capture-MS

Homo sapiens

137

Nfe2l2

Affinity Capture-MS

Mus musculus

138

C12orf74

Affinity Capture-MS

Homo sapiens

139

FOS

2353

Proximity Label-MS

Homo sapiens

140

MYC

Proximity Label-MS

Homo sapiens

141

KCTD17

79734

Affinity Capture-MS

Homo sapiens

142

SOHLH1

Affinity Capture-MS

Homo sapiens

143

TBL1X

6907

Co-fractionation

Homo sapiens

144

TRAF2

7186

Affinity Capture-MS

Homo sapiens

145

DNAJC10

54431

Affinity Capture-MS

Homo sapiens

146

RCN2

5955

Affinity Capture-MS

Homo sapiens

147

ACY1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

148

ZNF43

Affinity Capture-MS

Homo sapiens

149

DCAF15

Affinity Capture-MS

Homo sapiens

150

NANOG

Affinity Capture-MS

Homo sapiens

151

ZNF776

Affinity Capture-MS

Homo sapiens

152

ANGEL1

Affinity Capture-MS

Homo sapiens

153

SUPT16H

11198

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

154

TRIM4

89122

Affinity Capture-MS

Homo sapiens

155

TPM3

7170

Affinity Capture-MS

Homo sapiens

156

MLKL

197259

Affinity Capture-MS

Homo sapiens

157

RRM1

6240

Affinity Capture-MS

Homo sapiens

158

PELO

53918

Affinity Capture-MS

Homo sapiens

159

CRYAA

1409

Affinity Capture-MS

Homo sapiens

160

PLEKHA4

57664

Affinity Capture-MS

Homo sapiens

161

CDC20

991

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

162

HSPB2

Affinity Capture-MS

Homo sapiens

163

FAM53C

51307

Affinity Capture-MS

Homo sapiens

164

SKIL

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

165

ELF5

Proximity Label-MS

Homo sapiens

166

TUBG1

7283

Affinity Capture-MS

Homo sapiens

167

MTA1

9112

Co-fractionation

Homo sapiens

168

PDIA4

9601

Affinity Capture-MS

Homo sapiens

169

TRIM52

Affinity Capture-MS

Homo sapiens

170

CALU

813

Affinity Capture-MS

Homo sapiens

171

HDAC6

10013

Affinity Capture-MS

Homo sapiens

172

NLGN3

Two-hybrid

Homo sapiens

173

CHAMP1

Affinity Capture-MS

Homo sapiens

174

Trim24

Two-hybrid

Mus musculus

175

GFOD1

Affinity Capture-MS

Homo sapiens

176

KPNA6

23633

Affinity Capture-MS

Homo sapiens

177

BUB1B

Affinity Capture-Western

Homo sapiens

178

SMAD4

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

179

ANAPC1

64682

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

180

ELAVL1

1994

Affinity Capture-RNA

Homo sapiens

181

PJA2

Affinity Capture-MS

Homo sapiens

182

CHD1L

9557

Affinity Capture-MS		Homo sapiens
Co-localization		Homo sapiens
Affinity Capture-Western		Homo sapiens

183

ZNF764

92595

Affinity Capture-MS

Homo sapiens

184

NUP35

129401

Proximity Label-MS

Homo sapiens

185

MAGEA9

Affinity Capture-MS

Homo sapiens

186

RUNX1T1

Affinity Capture-MS

Homo sapiens

187

EDEM3

80267

Affinity Capture-MS

Homo sapiens

188

SSBP3

Affinity Capture-MS

Homo sapiens

189

ESR1

Affinity Capture-MS

Homo sapiens

190

NUP50

10762

Proximity Label-MS

Homo sapiens

191

TRIM37

Proximity Label-MS

Homo sapiens

192

ZIM2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

193

TCF4

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

194

LDB1

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

195

KRT38

8687

Affinity Capture-MS

Homo sapiens

196

RNF31

55072

Affinity Capture-MS

Homo sapiens

197

ZFP82

Affinity Capture-MS

Homo sapiens

198

CDK9

1025

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

199

DHX33

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens

200

SSSCA1

10534

Affinity Capture-MS

Homo sapiens

201

TCF3

Affinity Capture-MS

Homo sapiens

202

PNMA2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

203

CEP78

84131

Affinity Capture-MS

Homo sapiens

204

BRD1

23774

Affinity Capture-MS

Homo sapiens

205

SHARPIN

Affinity Capture-MS

Homo sapiens

206

ERG

Reconstituted Complex		Homo sapiens
Proximity Label-MS		Homo sapiens

207

PEX5

5830

Affinity Capture-MS

Homo sapiens

208

HIST1H3A

8350

Protein-peptide

Homo sapiens

209

GNB2L1

10399

Affinity Capture-MS

Homo sapiens

210

367

Proximity Label-MS

Homo sapiens

211

SSRP1

6749

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

212

CCT8L2

Affinity Capture-MS

Homo sapiens

213

SP7

Proximity Label-MS

Homo sapiens

214

CAV1

857

Affinity Capture-MS

Homo sapiens

215

C17orf53

Affinity Capture-MS

Homo sapiens

216

BCKDHA

593

Affinity Capture-MS

Homo sapiens

217

NIN

51199

Affinity Capture-MS

Homo sapiens

218

KDM5C

Affinity Capture-MS

Homo sapiens

219

SCO2

Affinity Capture-MS

Homo sapiens

View the network

Pathways in which TRIM33 is involved

Pathway	Evidence	Source
Developmental Biology	IEA	Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity	TAS	Reactome
Gastrulation	IEA	Reactome
Gene expression (Transcription)	TAS	Reactome
Generic Transcription Pathway	TAS	Reactome
Germ layer formation at gastrulation	IEA	Reactome
RNA Polymerase II Transcription	TAS	Reactome
Signal Transduction	TAS	Reactome
Signaling by TGF-beta Receptor Complex	TAS	Reactome
Signaling by TGFB family members	TAS	Reactome
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	TAS	Reactome

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