Gene description for TMX3
Gene name thioredoxin-related transmembrane protein 3
Gene symbol TMX3
Other names/aliases PDIA13
TXNDC10
Species Homo sapiens
 Database cross references - TMX3
ExoCarta ExoCarta_54495
Vesiclepedia VP_54495
Entrez Gene 54495
HGNC 24718
MIM 616102
UniProt Q96JJ7  
 TMX3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TMX3
Molecular Function
    protein disulfide isomerase activity GO:0003756 IEA
    protein binding GO:0005515 IPI
    protein-disulfide reductase activity GO:0015035 IDA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 IBA
    cell surface GO:0009986 IDA
    platelet alpha granule membrane GO:0031092 TAS
 Experiment description of studies that identified TMX3 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TMX3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 C9orf78 51759
Affinity Capture-MS Homo sapiens
2 DUSP22  
Affinity Capture-MS Homo sapiens
3 P2RX2  
Affinity Capture-MS Homo sapiens
4 CHCHD4  
Affinity Capture-MS Homo sapiens
5 GJD3  
Proximity Label-MS Homo sapiens
6 HS2ST1 9653
Affinity Capture-MS Homo sapiens
7 NTRK1 4914
Affinity Capture-MS Homo sapiens
8 TMED10 10972
Affinity Capture-MS Homo sapiens
9 CYB5B 80777
Co-fractionation Homo sapiens
10 CHST5  
Affinity Capture-MS Homo sapiens
11 PDE2A  
Affinity Capture-MS Homo sapiens
12 RPN2 6185
Proximity Label-MS Homo sapiens
13 CUL3 8452
Affinity Capture-MS Homo sapiens
14 CANX 821
Affinity Capture-MS Homo sapiens
15 METTL7A 25840
Proximity Label-MS Homo sapiens
16 LRRC59 55379
Proximity Label-MS Homo sapiens
17 RNF170 81790
Affinity Capture-MS Homo sapiens
18 CLPP 8192
Proximity Label-MS Homo sapiens
19 CHST8 64377
Affinity Capture-MS Homo sapiens
20 HSD17B11 51170
Proximity Label-MS Homo sapiens
21 TRIM66  
Affinity Capture-MS Homo sapiens
22 FUT8 2530
Affinity Capture-MS Homo sapiens
23 PLD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
24 BRD8 10902
Affinity Capture-MS Homo sapiens
25 BCAP31 10134
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 HSD3B7 80270
Proximity Label-MS Homo sapiens
27 ECEL1  
Affinity Capture-MS Homo sapiens
28 TRIM33 51592
Affinity Capture-MS Homo sapiens
29 FHL3 2275
Two-hybrid Homo sapiens
30 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
31 LOC100132735  
Protein-RNA Homo sapiens
32 B3GALT4  
Affinity Capture-MS Homo sapiens
33 FBXO6 26270
Affinity Capture-MS Homo sapiens
34 DNAJC25 548645
Proximity Label-MS Homo sapiens
35 NUP35 129401
Proximity Label-MS Homo sapiens
36 TAF1  
Affinity Capture-MS Homo sapiens
37 BRE 9577
Affinity Capture-MS Homo sapiens
38 APP 351
Reconstituted Complex Homo sapiens
39 AP1G2 8906
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 SLC7A5 8140
Affinity Capture-MS Homo sapiens
41 ST3GAL4 6484
Affinity Capture-MS Homo sapiens
42 LPCAT2 54947
Affinity Capture-MS Homo sapiens
43 PARK2  
Affinity Capture-MS Homo sapiens
44 PTPN21 11099
Affinity Capture-MS Homo sapiens
45 SEC61B 10952
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 CNR2  
Affinity Capture-MS Homo sapiens
47 SEC62 7095
Proximity Label-MS Homo sapiens
48 ATP2A1 487
Proximity Label-MS Homo sapiens
49 OGT 8473
Reconstituted Complex Homo sapiens
50 UGT1A7 54577
Affinity Capture-MS Homo sapiens
51 BRD1 23774
Affinity Capture-MS Homo sapiens
52 SLC25A18  
Affinity Capture-MS Homo sapiens
53 SERBP1 26135
Affinity Capture-MS Homo sapiens
54 CLEC2B  
Affinity Capture-MS Homo sapiens
55 RNF2  
Affinity Capture-MS Homo sapiens
56 C9orf72  
Affinity Capture-MS Homo sapiens
57 ST8SIA5  
Affinity Capture-MS Homo sapiens
58 TMEM129  
Affinity Capture-MS Homo sapiens
59 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
60 ST8SIA3  
Affinity Capture-MS Homo sapiens
61 RER1 11079
Affinity Capture-MS Homo sapiens
62 MAP3K15  
Affinity Capture-MS Homo sapiens
63 PTPN18 26469
Affinity Capture-MS Homo sapiens
64 LMNA 4000
Proximity Label-MS Homo sapiens
65 RPA3 6119
Proximity Label-MS Homo sapiens
66 ELOVL5 60481
Proximity Label-MS Homo sapiens
67 Ksr1  
Affinity Capture-MS Mus musculus
68 DRG2 1819
Affinity Capture-MS Homo sapiens
69 ZACN  
Affinity Capture-MS Homo sapiens
70 DERL1 79139
Proximity Label-MS Homo sapiens
71 CCDC47 57003
Affinity Capture-MS Homo sapiens
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