Gene description for UGT1A7
Gene name UDP glucuronosyltransferase 1 family, polypeptide A7
Gene symbol UGT1A7
Other names/aliases UDPGT
UDPGT 1-7
UGT-1G
UGT1-07
UGT1.7
UGT1G
Species Homo sapiens
 Database cross references - UGT1A7
ExoCarta ExoCarta_54577
Vesiclepedia VP_54577
Entrez Gene 54577
HGNC 12539
MIM 606432
UniProt Q9HAW7  
 UGT1A7 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for UGT1A7
Molecular Function
    retinoic acid binding GO:0001972 IDA
    enzyme inhibitor activity GO:0004857 IDA
    enzyme inhibitor activity GO:0004857 IGI
    protein kinase C binding GO:0005080 IDA
    glucuronosyltransferase activity GO:0015020 IDA
    glucuronosyltransferase activity GO:0015020 IGI
    enzyme binding GO:0019899 IBA
    enzyme binding GO:0019899 IPI
    protein homodimerization activity GO:0042803 IDA
    protein heterodimerization activity GO:0046982 IEA
    protein heterodimerization activity GO:0046982 IPI
Biological Process
    liver development GO:0001889 IBA
    fatty acid metabolic process GO:0006631 IDA
    xenobiotic metabolic process GO:0006805 IC
    xenobiotic metabolic process GO:0006805 IDA
    xenobiotic metabolic process GO:0006805 IDA
    estrogen metabolic process GO:0008210 IDA
    toxin catabolic process GO:0009407 IDA
    coumarin metabolic process GO:0009804 IC
    retinoic acid metabolic process GO:0042573 IC
    negative regulation of fatty acid metabolic process GO:0045922 IDA
    flavone metabolic process GO:0051552 IC
    cellular glucuronidation GO:0052695 IBA
    cellular glucuronidation GO:0052695 IDA
    flavonoid glucuronidation GO:0052696 IDA
    xenobiotic glucuronidation GO:0052697 IDA
    negative regulation of cellular glucuronidation GO:2001030 IDA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum GO:0005783 NAS
    endoplasmic reticulum membrane GO:0005789 IEA
    endoplasmic reticulum membrane GO:0005789 IKR
    endoplasmic reticulum membrane GO:0005789 NAS
 Experiment description of studies that identified UGT1A7 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for UGT1A7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ADAM10 102
Affinity Capture-MS Homo sapiens
2 ABHD12 26090
Affinity Capture-MS Homo sapiens
3 SEL1L3  
Affinity Capture-MS Homo sapiens
4 MR1  
Affinity Capture-MS Homo sapiens
5 CD320 51293
Affinity Capture-MS Homo sapiens
6 ST14 6768
Affinity Capture-MS Homo sapiens
7 FGFR1 2260
Affinity Capture-MS Homo sapiens
8 CLGN 1047
Affinity Capture-MS Homo sapiens
9 TMEM59 9528
Affinity Capture-MS Homo sapiens
10 TMX3 54495
Affinity Capture-MS Homo sapiens
11 RGAG1  
Affinity Capture-MS Homo sapiens
12 SCNN1A  
Affinity Capture-MS Homo sapiens
13 HLA-E 3133
Affinity Capture-MS Homo sapiens
14 HLA-DQB1 3119
Affinity Capture-MS Homo sapiens
15 CERK 64781
Affinity Capture-MS Homo sapiens
16 LMAN2L 81562
Affinity Capture-MS Homo sapiens
17 STIM1 6786
Affinity Capture-MS Homo sapiens
18 FZD6 8323
Affinity Capture-MS Homo sapiens
19 GPX8 493869
Affinity Capture-MS Homo sapiens
20 CNPY3 10695
Affinity Capture-MS Homo sapiens
21 TMX1 81542
Affinity Capture-MS Homo sapiens
22 GLB1L2  
Affinity Capture-MS Homo sapiens
23 TMEM246 84302
Affinity Capture-MS Homo sapiens
24 MARC1  
Affinity Capture-MS Homo sapiens
25 ECE1 1889
Affinity Capture-MS Homo sapiens
26 ROR2 4920
Affinity Capture-MS Homo sapiens
27 ITGA2 3673
Affinity Capture-MS Homo sapiens
28 APLP2 334
Affinity Capture-MS Homo sapiens
29 ARL10  
Affinity Capture-MS Homo sapiens
30 ITFG1 81533
Affinity Capture-MS Homo sapiens
31 EXT2 2132
Affinity Capture-MS Homo sapiens
32 LMF1 64788
Affinity Capture-MS Homo sapiens
33 PTPRS 5802
Affinity Capture-MS Homo sapiens
34 MAN2A2 4122
Affinity Capture-MS Homo sapiens
35 B3GNT2 10678
Affinity Capture-MS Homo sapiens
36 HLA-F 3134
Affinity Capture-MS Homo sapiens
37 CYP19A1  
Affinity Capture-MS Homo sapiens
38 FUT1  
Affinity Capture-MS Homo sapiens
39 UGT1A9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 SRC 6714
Affinity Capture-MS Homo sapiens
41 ADGRG6 57211
Affinity Capture-MS Homo sapiens
42 HLA-DRB1 3123
Affinity Capture-MS Homo sapiens
43 LOC100507703  
Affinity Capture-MS Homo sapiens
44 UGT1A8  
Affinity Capture-MS Homo sapiens
45 PBXIP1 57326
Affinity Capture-MS Homo sapiens
46 UGT1A10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 SUSD2 56241
Affinity Capture-MS Homo sapiens
48 HLA-A 3105
Affinity Capture-MS Homo sapiens
49 ESYT1 23344
Affinity Capture-MS Homo sapiens
50 MAGT1 84061
Affinity Capture-MS Homo sapiens
51 MFGE8 4240
Affinity Capture-MS Homo sapiens
52 SUN2 25777
Affinity Capture-MS Homo sapiens
53 NLGN2 57555
Affinity Capture-MS Homo sapiens
54 DNAJC16  
Affinity Capture-MS Homo sapiens
55 DGCR2 9993
Affinity Capture-MS Homo sapiens
56 ITM2B 9445
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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