Gene description for FZD6
Gene name frizzled class receptor 6
Gene symbol FZD6
Other names/aliases FZ-6
FZ6
HFZ6
NDNC10
Species Homo sapiens
 Database cross references - FZD6
ExoCarta ExoCarta_8323
Entrez Gene 8323
HGNC 4044
MIM 603409
UniProt O60353  
 FZD6 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for FZD6
Molecular Function
    protein binding GO:0005515 IPI
    ubiquitin protein ligase binding GO:0031625 IPI
    Wnt-activated receptor activity GO:0042813 IDA
    G-protein coupled receptor activity GO:0004930 IBA
    Wnt-protein binding GO:0017147 ISS
Biological Process
    G-protein coupled receptor signaling pathway GO:0007186 IEA
    platelet activation GO:0030168 IEA
    inner ear morphogenesis GO:0042472 IEA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IMP
    neural tube closure GO:0001843 IEA
    embryonic nail plate morphogenesis GO:0035880 IEA
    Wnt signaling pathway, planar cell polarity pathway GO:0060071 IEA
    non-canonical Wnt signaling pathway GO:0035567 IDA
    negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 IDA
    cell proliferation in midbrain GO:0033278 IEA
    establishment of planar polarity GO:0001736 IEA
    hair follicle development GO:0001942 IEA
    canonical Wnt signaling pathway GO:0060070 IBA
Subcellular Localization
    integral component of plasma membrane GO:0005887 ISS
    apicolateral plasma membrane GO:0016327 IEA
    apical plasma membrane GO:0016324 IEA
    integral component of membrane GO:0016021 IBA
    cell surface GO:0009986 IEA
    cytoplasmic vesicle membrane GO:0030659 IEA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified FZD6 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for FZD6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SFRP1 6422
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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