Gene description for EP300
Gene name	E1A binding protein p300
Gene symbol	EP300
Other names/aliases	KAT3B RSTS2 p300
Species	Homo sapiens
Database cross references - EP300
ExoCarta	ExoCarta_2033
Vesiclepedia	VP_2033
Entrez Gene	2033
HGNC	3373
MIM	602700
UniProt	Q09472
EP300 identified in exosomes derived from the following tissue/cell type
Endothelial cells	26027894

Gene ontology annotations for EP300

Molecular Function     pre-mRNA intronic binding GO:0097157 IEA     RNA polymerase II activating transcription factor binding GO:0001102 IPI     activating transcription factor binding GO:0033613 IPI     protein C-terminus binding GO:0008022 IDA     RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IEA     transcription coactivator activity GO:0003713 IDA     transferase activity, transferring acyl groups GO:0016746 IDA     lysine N-acetyltransferase activity, acting on acetyl phosphate as donor GO:0004468 IDA     acetyltransferase activity GO:0016407 IMP     nuclear hormone receptor binding GO:0035257 IPI     core promoter binding GO:0001047 IDA     transcription factor binding GO:0008134 IPI     beta-catenin binding GO:0008013 IPI     chromatin DNA binding GO:0031490 IEA     protein binding GO:0005515 IPI     zinc ion binding GO:0008270 IEA     androgen receptor binding GO:0050681 IPI     histone acetyltransferase activity GO:0004402 IDA     DNA binding GO:0003677 IDA     damaged DNA binding GO:0003684 IDA     p53 binding GO:0002039 IEA     chromatin binding GO:0003682 IMP Biological Process     Notch signaling pathway GO:0007219 TAS     circadian rhythm GO:0007623 TAS     mitotic cell cycle GO:0000278 TAS     N-terminal peptidyl-lysine acetylation GO:0018076 IDA     regulation of cellular response to heat GO:1900034 TAS     regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 TAS     innate immune response GO:0045087 TAS     cellular response to UV GO:0034644 IDA     G2/M transition of mitotic cell cycle GO:0000086 TAS     histone H4 acetylation GO:0043967 IMP     positive regulation by host of viral transcription GO:0043923 IDA     viral process GO:0016032 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP     lung development GO:0030324 IEA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA     cellular response to hypoxia GO:0071456 TAS     response to hypoxia GO:0001666 IDA     heart development GO:0007507 IEA     cellular response to heat GO:0034605 TAS     regulation of cell cycle GO:0051726 TAS     internal peptidyl-lysine acetylation GO:0018393 IDA     regulation of transcription, DNA-templated GO:0006355 IDA     intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 IDA     positive regulation of type I interferon production GO:0032481 TAS     positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IDA     protein stabilization GO:0050821 ISS     stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS     somitogenesis GO:0001756 IEA     transcription, DNA-templated GO:0006351 IEA     chromatin organization GO:0006325 TAS     apoptotic process GO:0006915 IMP     skeletal muscle tissue development GO:0007519 IEA     response to estrogen GO:0043627 IDA     organ morphogenesis GO:0009887 IEA     nervous system development GO:0007399 TAS     protein acetylation GO:0006473 TAS     positive regulation of protein binding GO:0032092 IEA     histone H2B acetylation GO:0043969 IDA     regulation of androgen receptor signaling pathway GO:0060765 IDA     positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response GO:0006990 ISS     regulation of tubulin deacetylation GO:0090043 IDA     internal protein amino acid acetylation GO:0006475 IDA Subcellular Localization     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 TAS     histone acetyltransferase complex GO:0000123 IEA     cytoplasm GO:0005737 IDA     transcription factor complex GO:0005667 IEA