Gene description for EP300
Gene name	E1A binding protein p300
Gene symbol	EP300
Other names/aliases	KAT3B RSTS2 p300
Species	Homo sapiens
Database cross references - EP300
ExoCarta	ExoCarta_2033
Vesiclepedia	VP_2033
Entrez Gene	2033
HGNC	3373
MIM	602700
UniProt	Q09472
EP300 identified in sEVs derived from the following tissue/cell type
Endothelial cells	26027894

Gene ontology annotations for EP300

Molecular Function     transcription coregulator binding GO:0001221 IPI     transcription coactivator binding GO:0001223 IPI     p53 binding GO:0002039 IEA     DNA binding GO:0003677 IDA     chromatin binding GO:0003682 IDA     chromatin binding GO:0003682 IMP     damaged DNA binding GO:0003684 IDA     transcription coactivator activity GO:0003713 IBA     transcription coactivator activity GO:0003713 IDA     transcription coactivator activity GO:0003713 IMP     transcription coactivator activity GO:0003713 IPI     transcription coactivator activity GO:0003713 TAS     histone acetyltransferase activity GO:0004402 IBA     histone acetyltransferase activity GO:0004402 IDA     histone acetyltransferase activity GO:0004402 TAS     lysine N-acetyltransferase activity, acting on acetyl phosphate as donor GO:0004468 IDA     protein binding GO:0005515 IDA     protein binding GO:0005515 IPI     beta-catenin binding GO:0008013 IPI     zinc ion binding GO:0008270 IEA     histone H3 acetyltransferase activity GO:0010484 IDA     histone H4 acetyltransferase activity GO:0010485 IDA     histone H4 acetyltransferase activity GO:0010485 IMP     acetyltransferase activity GO:0016407 EXP     acetyltransferase activity GO:0016407 IDA     acetyltransferase activity GO:0016407 IMP     acyltransferase activity GO:0016746 IDA     nuclear receptor binding GO:0016922 IPI     chromatin DNA binding GO:0031490 IBA     histone H3K56 acetyltransferase activity GO:0032931 IEA     peptide N-acetyltransferase activity GO:0034212 TAS     histone H3K14 acetyltransferase activity GO:0036408 IEA     histone H3K9 acetyltransferase activity GO:0043992 IEA     histone H3K18 acetyltransferase activity GO:0043993 IDA     histone H3K23 acetyltransferase activity GO:0043994 IEA     histone H4K5 acetyltransferase activity GO:0043995 IEA     histone H4K8 acetyltransferase activity GO:0043996 IEA     histone H4K12 acetyltransferase activity GO:0043997 IEA     histone H2AK5 acetyltransferase activity GO:0043999 IEA     histone H2AK9 acetyltransferase activity GO:0044012 IEA     histone H2B acetyltransferase activity GO:0044013 IDA     histone H2BK5 acetyltransferase activity GO:0044014 IEA     histone H2BK12 acetyltransferase activity GO:0044015 IEA     histone H3K4 acetyltransferase activity GO:0044016 IEA     histone H3K27 acetyltransferase activity GO:0044017 IDA     histone H3K27 acetyltransferase activity GO:0044017 IMP     histone H3K36 acetyltransferase activity GO:0044018 IEA     histone H4K16 acetyltransferase activity GO:0046972 IEA     tau protein binding GO:0048156 NAS     nuclear androgen receptor binding GO:0050681 IPI     NF-kappaB binding GO:0051059 IPI     RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI     peptide-lysine-N-acetyltransferase activity GO:0061733 IDA     peptide-lysine-N-acetyltransferase activity GO:0061733 TAS     protein propionyltransferase activity GO:0061920 IDA     pre-mRNA intronic binding GO:0097157 IEA     STAT family protein binding GO:0097677 IPI     peptide 2-hydroxyisobutyryltransferase activity GO:0106226 IEA     histone lactyltransferase (CoA-dependent) activity GO:0120301 IDA     acetylation-dependent protein binding GO:0140033 IDA     peptide butyryltransferase activity GO:0140065 IDA     histone crotonyltransferase activity GO:0140068 IDA     histone butyryltransferase activity GO:0140069 IEA     DNA-binding transcription factor binding GO:0140297 IPI     histone H3K122 acetyltransferase activity GO:0140908 IDA     histone H4K16 propionyltransferase activity GO:0141002 IEA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IDA     response to hypoxia GO:0001666 IDA     somitogenesis GO:0001756 IEA     thigmotaxis GO:0001966 IEA     behavioral defense response GO:0002209 IEA     stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS     regulation of glycolytic process GO:0006110 IDA     protein acetylation GO:0006473 IDA     internal protein amino acid acetylation GO:0006475 IDA     apoptotic process GO:0006915 IMP     canonical NF-kappaB signal transduction GO:0007249 IDA     nervous system development GO:0007399 TAS     heart development GO:0007507 IEA     skeletal muscle tissue development GO:0007519 IEA     learning or memory GO:0007611 IEA     circadian rhythm GO:0007623 ISS     animal organ morphogenesis GO:0009887 IEA     regulation of autophagy GO:0010506 TAS     negative regulation of autophagy GO:0010507 IDA     regulation of mitochondrion organization GO:0010821 ISS     positive regulation of neuron projection development GO:0010976 IDA     N-terminal peptidyl-lysine acetylation GO:0018076 IDA     internal peptidyl-lysine acetylation GO:0018393 IDA     peptidyl-lysine acetylation GO:0018394 IDA     B cell differentiation GO:0030183 IEA     platelet formation GO:0030220 IEA     lung development GO:0030324 IEA     positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 IMP     negative regulation of protein-containing complex assembly GO:0031333 IDA     protein destabilization GO:0031648 IMP     cellular response to nutrient levels GO:0031669 IDA     cellular response to UV GO:0034644 IDA     multicellular organism growth GO:0035264 IEA     megakaryocyte development GO:0035855 IEA     swimming GO:0036268 IEA     positive regulation of protein import into nucleus GO:0042307 IDA     intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 IDA     response to estrogen GO:0043627 IDA     positive regulation by host of viral transcription GO:0043923 IDA     fat cell differentiation GO:0045444 ISS     negative regulation of gluconeogenesis GO:0045721 IDA     transcription initiation-coupled chromatin remodeling GO:0045815 IDA     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of DNA-templated transcription GO:0045893 TAS     positive regulation of transcription by RNA polymerase II GO:0045944 IBA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 ISS     positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 IDA     protein stabilization GO:0050821 ISS     positive regulation of DNA-binding transcription factor activity GO:0051091 IDA     face morphogenesis GO:0060325 IEA     regulation of androgen receptor signaling pathway GO:0060765 IDA     peptidyl-lysine propionylation GO:0061921 IDA     cellular response to L-leucine GO:0071233 IDA     regulation of tubulin deacetylation GO:0090043 IDA     peptidyl-lysine crotonylation GO:0140066 IDA     peptidyl-lysine butyrylation GO:0140067 IDA     regulation of cellular response to heat GO:1900034 TAS     regulation of signal transduction by p53 class mediator GO:1901796 TAS     positive regulation of TORC1 signaling GO:1904263 IDA     positive regulation of TORC2 signaling GO:1904515 IDA     positive regulation of T-helper 17 cell lineage commitment GO:2000330 IDA Subcellular Localization     histone acetyltransferase complex GO:0000123 IBA     chromatin GO:0000785 IDA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     transcription regulator complex GO:0005667 IBA     cytoplasm GO:0005737 IDA     cytosol GO:0005829 IDA     cytosol GO:0005829 IDA     protein-DNA complex GO:0032993 ISS