Gene description for CITED1
Gene name Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
Gene symbol CITED1
Other names/aliases MSG1
Species Homo sapiens
 Database cross references - CITED1
ExoCarta ExoCarta_4435
Entrez Gene 4435
HGNC 1986
MIM 300149
UniProt Q99966  
 CITED1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CITED1
Molecular Function
    co-SMAD binding GO:0070410 IPI
    protein C-terminus binding GO:0008022 IPI
    protein binding GO:0005515 IPI
    LBD domain binding GO:0050693 IDA
    sequence-specific DNA binding transcription factor activity GO:0003700 NAS
    transcription coactivator activity GO:0003713 IDA
    protein homodimerization activity GO:0042803 IDA
    chromatin binding GO:0003682 ISS
    transcription regulatory region DNA binding GO:0044212 IDA
Biological Process
    negative regulation of osteoblast differentiation GO:0045668 ISS
    response to interleukin-11 GO:0071105 ISS
    negative regulation of neuron apoptotic process GO:0043524 IDA
    positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 TAS
    negative regulation of Wnt signaling pathway GO:0030178 TAS
    response to interleukin-1 GO:0070555 ISS
    spongiotrophoblast layer development GO:0060712 IEA
    regulation of transcription from RNA polymerase II promoter GO:0006357 TAS
    response to insulin GO:0032868 ISS
    response to estrogen GO:0043627 TAS
    response to cAMP GO:0051591 ISS
    transforming growth factor beta receptor signaling pathway GO:0007179 IDA
    negative regulation of transcription, DNA-templated GO:0045892 ISS
    branching involved in ureteric bud morphogenesis GO:0001658 ISS
    vasculogenesis GO:0001570 IEA
    embryonic axis specification GO:0000578 IEA
    pigmentation GO:0043473 IMP
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    melanocyte differentiation GO:0030318 IMP
    brain development GO:0007420 IEA
    metanephros development GO:0001656 TAS
    response to lipopolysaccharide GO:0032496 ISS
    positive regulation of gene expression GO:0010628 ISS
    response to interleukin-6 GO:0070741 ISS
    response to transforming growth factor beta GO:0071559 IDA
    cell proliferation GO:0008283 TAS
    response to parathyroid hormone GO:0071107 ISS
    response to interferon-gamma GO:0034341 ISS
    response to interleukin-4 GO:0070670 ISS
    melanin biosynthetic process GO:0042438 ISS
    response to interleukin-2 GO:0070669 ISS
    mesenchymal to epithelial transition GO:0060231 TAS
    placenta development GO:0001890 ISS
    transcription, DNA-templated GO:0006351 IEA
    response to interleukin-9 GO:0071104 ISS
    negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003340 IEA
    SMAD protein signal transduction GO:0060395 IDA
    response to cytokine GO:0034097 ISS
    labyrinthine layer development GO:0060711 IEA
    apoptotic process GO:0006915 IEA
    nucleocytoplasmic transport GO:0006913 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified CITED1 in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CITED1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSPA8 3312
Affinity Capture-Western Homo sapiens
Phenotypic Suppression Homo sapiens
2 SMAD4  
Invitro Homo sapiens
Two-hybrid Homo sapiens
3 EP300 2033
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
4 TFAP2B  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which CITED1 is involved
No pathways found

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