Gene description for CITED1
Gene name Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
Gene symbol CITED1
Other names/aliases MSG1
Species Homo sapiens
 Database cross references - CITED1
ExoCarta ExoCarta_4435
Vesiclepedia VP_4435
Entrez Gene 4435
HGNC 1986
MIM 300149
UniProt Q99966  
 CITED1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CITED1
Molecular Function
    chromatin binding GO:0003682 ISS
    transcription coactivator activity GO:0003713 IBA
    transcription coactivator activity GO:0003713 IDA
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IDA
    LBD domain binding GO:0050693 IDA
    co-SMAD binding GO:0070410 IPI
Biological Process
    vasculogenesis GO:0001570 IEA
    metanephros development GO:0001656 TAS
    branching involved in ureteric bud morphogenesis GO:0001658 ISS
    placenta development GO:0001890 ISS
    regulation of transcription by RNA polymerase II GO:0006357 TAS
    nucleocytoplasmic transport GO:0006913 IDA
    apoptotic process GO:0006915 IEA
    transforming growth factor beta receptor signaling pathway GO:0007179 IDA
    brain development GO:0007420 IEA
    positive regulation of gene expression GO:0010628 ISS
    negative regulation of Wnt signaling pathway GO:0030178 TAS
    melanocyte differentiation GO:0030318 IBA
    melanocyte differentiation GO:0030318 IEP
    positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 TAS
    response to lipopolysaccharide GO:0032496 ISS
    response to insulin GO:0032868 ISS
    response to cytokine GO:0034097 ISS
    response to type II interferon GO:0034341 ISS
    melanin biosynthetic process GO:0042438 ISS
    regulation of apoptotic process GO:0042981 IDA
    pigmentation GO:0043473 IEP
    negative regulation of neuron apoptotic process GO:0043524 IDA
    response to estrogen GO:0043627 IDA
    response to estrogen GO:0043627 TAS
    negative regulation of osteoblast differentiation GO:0045668 ISS
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative regulation of DNA-templated transcription GO:0045892 ISS
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    response to cAMP GO:0051591 ISS
    mesenchymal to epithelial transition GO:0060231 TAS
    SMAD protein signal transduction GO:0060395 IDA
    labyrinthine layer development GO:0060711 IEA
    response to interleukin-1 GO:0070555 ISS
    response to interleukin-2 GO:0070669 ISS
    response to interleukin-4 GO:0070670 ISS
    response to interleukin-6 GO:0070741 ISS
    response to interleukin-9 GO:0071104 ISS
    response to interleukin-11 GO:0071105 ISS
    response to parathyroid hormone GO:0071107 ISS
    response to transforming growth factor beta GO:0071559 IDA
    positive regulation of mesenchymal stem cell proliferation GO:1902462 TAS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified CITED1 in exosomes
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CITED1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TFAP2B  
Reconstituted Complex Homo sapiens
2 VPS35 55737
Affinity Capture-MS Homo sapiens
3 SMC3 9126
Affinity Capture-MS Homo sapiens
4 RBL1  
Affinity Capture-MS Homo sapiens
5 EPM2AIP1 9852
Affinity Capture-MS Homo sapiens
6 CCNA2 890
Affinity Capture-MS Homo sapiens
7 HSPA8 3312
Affinity Capture-Western Homo sapiens
Phenotypic Suppression Homo sapiens
8 FCGRT 2217
Affinity Capture-MS Homo sapiens
9 RB1 5925
Affinity Capture-MS Homo sapiens
10 AURKA 6790
Affinity Capture-MS Homo sapiens
11 CTNNB1 1499
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 SETX  
Affinity Capture-MS Homo sapiens
13 SMAD4  
Two-hybrid Homo sapiens
14 USP11 8237
Affinity Capture-MS Homo sapiens
15 EGLN1 54583
Affinity Capture-MS Homo sapiens
16 CREBBP  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
17 CDK2 1017
Affinity Capture-MS Homo sapiens
18 STK36  
Affinity Capture-MS Homo sapiens
19 TCEAL1  
Affinity Capture-MS Homo sapiens
20 ESR1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
21 STAG1  
Affinity Capture-MS Homo sapiens
22 VPS26A 9559
Affinity Capture-MS Homo sapiens
23 UBB 7314
Affinity Capture-MS Homo sapiens
24 RAD21 5885
Affinity Capture-MS Homo sapiens
25 RBL2 5934
Affinity Capture-MS Homo sapiens
26 MGME1  
Affinity Capture-MS Homo sapiens
27 MYO9B 4650
Affinity Capture-MS Homo sapiens
28 RLIM 51132
Affinity Capture-MS Homo sapiens
29 SMC1A 8243
Affinity Capture-MS Homo sapiens
30 LNX1  
Two-hybrid Homo sapiens
31 STAG2 10735
Affinity Capture-MS Homo sapiens
32 EP300 2033
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
33 BDH2 56898
Affinity Capture-MS Homo sapiens
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