Gene description for STAG2
Gene name stromal antigen 2
Gene symbol STAG2
Other names/aliases SA-2
SA2
SCC3B
bA517O1.1
Species Homo sapiens
 Database cross references - STAG2
ExoCarta ExoCarta_10735
Entrez Gene 10735
HGNC 11355
MIM 300826
UniProt Q8N3U4  
 STAG2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for STAG2
Molecular Function
    chromatin binding GO:0003682 IEA
    protein binding GO:0005515 IPI
Biological Process
    stem cell maintenance GO:0019827 IEA
    post-translational protein modification GO:0043687 TAS
    sister chromatid cohesion GO:0007062 IMP
    negative regulation of DNA endoreduplication GO:0032876 IMP
    mitotic cell cycle GO:0000278 TAS
    meiotic cell cycle GO:0051321 IEA
    mitotic nuclear division GO:0007067 IEA
    cellular protein metabolic process GO:0044267 TAS
    protein sumoylation GO:0016925 TAS
    cell division GO:0051301 IEA
Subcellular Localization
    membrane GO:0016020 IDA
    plasma membrane GO:0005886 IDA
    actin cytoskeleton GO:0015629 IDA
    nucleus GO:0005634 TAS
    chromosome, centromeric region GO:0000775 TAS
    chromosome GO:0005694 TAS
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 TAS
    chromatin GO:0000785 IDA
    nucleolus GO:0005730 IDA
    intermediate filament cytoskeleton GO:0045111 IDA
 Experiment description of studies that identified STAG2 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for STAG2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PDS5A 23244
Affinity Capture-Western Homo sapiens
2 STAG1  
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here