Gene description for EPHA1
Gene name EPH receptor A1
Gene symbol EPHA1
Other names/aliases EPH
EPHT
EPHT1
Species Homo sapiens
 Database cross references - EPHA1
ExoCarta ExoCarta_2041
Entrez Gene 2041
HGNC 3385
MIM 179610
UniProt P21709  
 EPHA1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for EPHA1
Molecular Function
    ATP binding GO:0005524 IEA
    protein kinase binding GO:0019901 IPI
    transmembrane-ephrin receptor activity GO:0005005 IDA
    protein kinase activity GO:0004672 IDA
Biological Process
    positive regulation of cell proliferation GO:0008284 IMP
    protein autophosphorylation GO:0046777 IDA
    positive regulation of cell migration GO:0030335 IMP
    substrate adhesion-dependent cell spreading GO:0034446 IDA
    angiogenesis GO:0001525 IEA
    regulation of GTPase activity GO:0043087 IDA
    activation of GTPase activity GO:0090630 IDA
    negative regulation of protein kinase activity GO:0006469 IDA
    axon guidance GO:0007411 TAS
    positive regulation of cell-matrix adhesion GO:0001954 IDA
    ephrin receptor signaling pathway GO:0048013 TAS
    positive regulation of stress fiber assembly GO:0051496 ISS
    positive regulation of angiogenesis GO:0045766 IMP
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    negative regulation of cell migration GO:0030336 IDA
    somatic stem cell maintenance GO:0035019 TAS
    cell surface receptor signaling pathway GO:0007166 IDA
Subcellular Localization
    integral component of plasma membrane GO:0005887 IDA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified EPHA1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for EPHA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EFNA1  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml



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