Gene description for MTMR14
Gene name myotubularin related protein 14
Gene symbol MTMR14
Other names/aliases C3orf29
Species Homo sapiens
 Database cross references - MTMR14
ExoCarta ExoCarta_64419
Vesiclepedia VP_64419
Entrez Gene 64419
HGNC 26190
MIM 611089
UniProt Q8NCE2  
 MTMR14 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for MTMR14
Molecular Function
    phosphatidylinositol-3-phosphate phosphatase activity GO:0004438 IBA
    phosphatidylinositol-3-phosphate phosphatase activity GO:0004438 IDA
    phosphatidylinositol-3-phosphate phosphatase activity GO:0004438 TAS
    protein serine/threonine phosphatase activity GO:0004722 TAS
    protein binding GO:0005515 IPI
    phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity GO:0052629 IDA
    phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity GO:0052629 TAS
Biological Process
    phosphatidylinositol biosynthetic process GO:0006661 TAS
    macroautophagy GO:0016236 TAS
Subcellular Localization
    ruffle GO:0001726 IDA
    cytosol GO:0005829 TAS
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified MTMR14 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MTMR14
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 AFM 173
Affinity Capture-MS Homo sapiens
3 MAPK1IP1L 93487
Affinity Capture-MS Homo sapiens
4 POSTN 10631
Affinity Capture-MS Homo sapiens
5 TP53BP2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
6 TRAF2 7186
Affinity Capture-MS Homo sapiens
7 PTCH1  
Affinity Capture-MS Homo sapiens
8 TIE1  
Two-hybrid Homo sapiens
9 ATG9A 79065
Proximity Label-MS Homo sapiens
10 IGHA1 3493
Affinity Capture-MS Homo sapiens
11 EPHA7 2045
Two-hybrid Homo sapiens
12 FAS 355
Proximity Label-MS Homo sapiens
13 EPHB2 2048
Two-hybrid Homo sapiens
14 CHURC1  
Affinity Capture-MS Homo sapiens
15 DUSP7  
Affinity Capture-MS Homo sapiens
16 MTMR14 64419
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 DIABLO 56616
Affinity Capture-MS Homo sapiens
18 SFXN4  
Affinity Capture-MS Homo sapiens
19 ACAD8 27034
Affinity Capture-MS Homo sapiens
20 ATXN10 25814
Affinity Capture-MS Homo sapiens
21 FAM90A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 HSD17B12 51144
Affinity Capture-MS Homo sapiens
23 ACOT8 10005
Affinity Capture-MS Homo sapiens
24 APP 351
Reconstituted Complex Homo sapiens
25 TMPO 7112
Affinity Capture-MS Homo sapiens
26 LTK 4058
Two-hybrid Homo sapiens
27 UFL1 23376
Affinity Capture-MS Homo sapiens
28 IDE 3416
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 XPO1 7514
Affinity Capture-MS Homo sapiens
30 PLS1 5357
Affinity Capture-MS Homo sapiens
31 DNM1L 10059
Affinity Capture-MS Homo sapiens
32 SOAT1 6646
Affinity Capture-MS Homo sapiens
33 GNB1L 54584
Affinity Capture-MS Homo sapiens
34 ACSL3 2181
Affinity Capture-MS Homo sapiens
35 CARM1 10498
Affinity Capture-MS Homo sapiens
36 GMPPA 29926
Affinity Capture-MS Homo sapiens
37 GABARAP 11337
Affinity Capture-MS Homo sapiens
38 CYLD  
Affinity Capture-MS Homo sapiens
39 BPIFB1 92747
Affinity Capture-MS Homo sapiens
40 NPPC  
Affinity Capture-MS Homo sapiens
41 AKR7A2 8574
Affinity Capture-MS Homo sapiens
42 PLK1 5347
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 MIA3 375056
Affinity Capture-MS Homo sapiens
44 SPANXN4  
Affinity Capture-MS Homo sapiens
45 PYCRL 65263
Affinity Capture-MS Homo sapiens
46 BICD2 23299
Proximity Label-MS Homo sapiens
47 WDR54  
Affinity Capture-MS Homo sapiens
48 SEH1L 81929
Affinity Capture-MS Homo sapiens
49 RAB10 10890
Affinity Capture-MS Homo sapiens
50 PLEKHG3 26030
Affinity Capture-MS Homo sapiens
51 PDP1 54704
Affinity Capture-MS Homo sapiens
52 PRMT1 3276
Affinity Capture-MS Homo sapiens
53 ACSL4 2182
Affinity Capture-MS Homo sapiens
54 EPHA1 2041
Two-hybrid Homo sapiens
55 AASDHPPT 60496
Affinity Capture-MS Homo sapiens
56 ARHGAP20  
Affinity Capture-MS Homo sapiens
57 SCCPDH 51097
Affinity Capture-MS Homo sapiens
58 SCO2  
Affinity Capture-MS Homo sapiens
59 PDIA6 10130
Affinity Capture-MS Homo sapiens
60 CDK4 1019
Affinity Capture-MS Homo sapiens
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