Gene description for MTMR14
Gene name myotubularin related protein 14
Gene symbol MTMR14
Other names/aliases C3orf29
Species Homo sapiens
 Database cross references - MTMR14
ExoCarta ExoCarta_64419
Vesiclepedia VP_64419
Entrez Gene 64419
HGNC 26190
MIM 611089
UniProt Q8NCE2  
 MTMR14 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for MTMR14
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 IEA
    protein binding GO:0005515 IPI
    phosphatidylinositol-3-phosphatase activity GO:0004438 IDA
Biological Process
    phospholipid metabolic process GO:0006644 TAS
    small molecule metabolic process GO:0044281 TAS
    phosphatidylinositol biosynthetic process GO:0006661 TAS
    peptidyl-tyrosine dephosphorylation GO:0035335 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    perinuclear region of cytoplasm GO:0048471 IDA
    ruffle GO:0001726 IDA
 Experiment description of studies that identified MTMR14 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MTMR14
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MTMR14 is involved
PathwayEvidenceSource
Synthesis of PIPs at the plasma membrane TAS Reactome





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