Gene description for SEH1L
Gene name SEH1-like (S. cerevisiae)
Gene symbol SEH1L
Other names/aliases SEC13L
SEH1A
SEH1B
Seh1
Species Homo sapiens
 Database cross references - SEH1L
ExoCarta ExoCarta_81929
Vesiclepedia VP_81929
Entrez Gene 81929
HGNC 30379
MIM 609263
UniProt Q96EE3  
 SEH1L identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 34887515    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for SEH1L
Biological Process
    mitotic metaphase plate congression GO:0007080 IMP
    cytokine-mediated signaling pathway GO:0019221 TAS
    mRNA transport GO:0051028 IEA
    cellular protein metabolic process GO:0044267 TAS
    viral life cycle GO:0019058 TAS
    defense response to Gram-positive bacterium GO:0050830 IEA
    post-translational protein modification GO:0043687 TAS
    mitotic nuclear envelope disassembly GO:0007077 TAS
    small GTPase mediated signal transduction GO:0007264 TAS
    protein transport GO:0015031 IEA
    cytokine production involved in inflammatory response GO:0002534 IEA
    cell division GO:0051301 IEA
    nuclear pore organization GO:0006999 IMP
    regulation of glucose transport GO:0010827 TAS
    attachment of mitotic spindle microtubules to kinetochore GO:0051315 IMP
    glucose transport GO:0015758 TAS
    mitotic cell cycle GO:0000278 TAS
    hexose transport GO:0008645 TAS
    gene expression GO:0010467 TAS
    small molecule metabolic process GO:0044281 TAS
    carbohydrate metabolic process GO:0005975 TAS
    viral process GO:0016032 TAS
    viral transcription GO:0019083 TAS
    regulation of cellular response to heat GO:1900034 TAS
    cellular response to heat GO:0034605 TAS
    protein sumoylation GO:0016925 TAS
    transmembrane transport GO:0055085 TAS
Subcellular Localization
    nuclear envelope GO:0005635 TAS
    nuclear pore outer ring GO:0031080 NAS
    condensed chromosome kinetochore GO:0000777 IEA
    cytosol GO:0005829 TAS
    kinetochore GO:0000776 IDA
 Experiment description of studies that identified SEH1L in exosomes
1
Experiment ID 1203
MISEV standards
EM
EV Biophysical techniques
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ.
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
2
Experiment ID 488
MISEV standards
EM
EV Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
CANX
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 217
MISEV standards
EM
EV Biophysical techniques
TSG101|CD81|CD9|CD63
EV Enriched markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SEH1L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NUP107 57122
Affinity Capture-Western Homo sapiens
2 NUP133 55746
Affinity Capture-Western Homo sapiens
3 NUP85 79902
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which SEH1L is involved
No pathways found





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